{"product_id":"therapeutic-targeting-of-ras-mutant-cancers-paperback-9781009073646","title":"Therapeutic Targeting of RAS Mutant Cancers (Paperback \/ softback) 9781009073646","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eTherapeutic Targeting of RAS Mutant Cancers\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThis Element reviews key aspects of RAS biochemistry that are directly relevant to understanding the newly available RAS inhibitors.\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eEdward C. Stites (Author), Kendra Paskvan (Author), Shumei Kato (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781009073646, Cambridge University Press\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 15 September 2022\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e75 pages\u003cbr\u003e22.8 x 15.2 x 0.3 cm, 0.08 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled.  More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS.  Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eIntroduction\u003cbr\u003e RAS Biology\u003cbr\u003e Oncogenic RAS\u003cbr\u003e RAS Targeting\u003cbr\u003e Downstream Targeting\u003cbr\u003e Upstream Targeting\u003cbr\u003e Targeting Specific RAS Mutants\u003cbr\u003e KRAS G12C Targeting\u003cbr\u003e Direct Targeting of Other RAS Proteins\u003cbr\u003e KRAS G12R Pancreatic Cancer\u003cbr\u003e KRAS G13D Colorectal Cancer\u003cbr\u003e Summary\u003cbr\u003e References.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Pathology [\u003ca title=\"See our other books on Pathology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pathology%20%5BMMF%5D%22\"\u003eMMF\u003c\/a\u003e], Oncology [\u003ca title=\"See our other books on Oncology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Oncology%20%5BMJCL%5D%22\"\u003eMJCL\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":46265385877784,"sku":"9781009073646","price":17.39,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9781009073646i_68ebc9fc-6441-43b2-ad7a-3a8c95acf821.jpg?v=1696791118","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/therapeutic-targeting-of-ras-mutant-cancers-paperback-9781009073646","provider":"Freshly Printed Books","version":"1.0","type":"link"}