{"product_id":"the-genetics-and-biology-of-sex-determination-hardback-9780470843468","title":"The Genetics and Biology of Sex Determination (Hardback) 9780470843468","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eThe Genetics and Biology of Sex Determination\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eDerek J. Chadwick (Edited by), Novartis (Author), Jamie A. Goode (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470843468, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 21 March 2002\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e280 pages\u003cbr\u003e23.6 x 15.6 x 1.8 cm, 0.567 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"...The papers presented are of uniform high quality and this book is essential reading for any serious student of sex determination...\" (Human Genetics, October 2002)\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eNature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels.  A major landmark was the discovery in 1990 of the \u003ci\u003eSRY\u003c\/i\u003e gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice.   \u003cp\u003eThis book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms.\u003c\/p\u003e \u003cp\u003eBy bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eChair's Introduction (R. Short).\u003cbr\u003e \u003cbr\u003e Sex-determining genes in mice: building pathways (R. Lovell-Badge, et al.).\u003cbr\u003e \u003cbr\u003e Early gonadal development: exploring Wtl and Sox9 function (J. Guo, et al.).\u003cbr\u003e \u003cbr\u003e General Discussion I: The mechanism of action of SRY.\u003cbr\u003e \u003cbr\u003e Anomalies of human sexual development: clinical aspects and genetic analysis (E. Vilain).\u003cbr\u003e \u003cbr\u003e The molecular action of testis-determining factors SRY and SOX 9 (V. Harley).\u003cbr\u003e \u003cbr\u003e Concerted regulation of gonad differentiation by transcription factors and growth factors (T. Suzuki, et al.).\u003cbr\u003e \u003cbr\u003e General Discussion II.\u003cbr\u003e \u003cbr\u003e Evolution of the testis-determining gene - the rise and fall of SRY (Marshall Graves).\u003cbr\u003e \u003cbr\u003e A Comparative Analysis of vertebrate Sex Determination (A. Sinclair, et al.).\u003cbr\u003e \u003cbr\u003e Invertebrates may not be so different after all (D. Zarkower).\u003cbr\u003e \u003cbr\u003e The hormonal control of sexual development (M. Renfree, et al.).\u003cbr\u003e \u003cbr\u003e Genetic studies of MIS signalling in sexual development (S. Jamin, et al.)\u003cbr\u003e \u003cbr\u003e Social regulation of the brain: sex, size and status (R. Fernald).\u003cbr\u003e \u003cbr\u003e The battle of the sexes: opposing pathways in sex determination (H. Hung-Chang Yao, et al).\u003cbr\u003e \u003cbr\u003e General Discussion III: True Hermaphroditism and the Formation of the Ovotestis.\u003cbr\u003e \u003cbr\u003e The evolution of chromosomal sex determination (B. Charlesworth).\u003cbr\u003e \u003cbr\u003e The molecular genetic jigsaw puzzle of vertebrate sex determination and its missing pieces (G. Scherer).\u003cbr\u003e \u003cbr\u003e Expression-based strategies for discover of genes involved in testis and ovary development (P. Koopman, et al.).\u003cbr\u003e \u003cbr\u003e Final General Discussion.\u003cbr\u003e \u003cbr\u003e Index of Contributors.\u003cbr\u003e \u003cbr\u003e Subject Index.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biology, life sciences [\u003ca title=\"See our other books on Biology, life sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biology,%20life%20sciences%20%5BPS%5D%22\"\u003ePS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52278030991640,"sku":"9780470843468","price":117.28,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470843468.jpg?v=1781456745","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/the-genetics-and-biology-of-sex-determination-hardback-9780470843468","provider":"Freshly Printed Books","version":"1.0","type":"link"}