{"product_id":"the-colors-of-mice-a-model-genetic-network-hardback-9781405179546","title":"The Colors of Mice; A Model Genetic Network (Hardback) 9781405179546","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eThe Colors of Mice\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eA Model Genetic Network\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eM. Lynn Lamoreux (Author), Véronique Delmas (Author), Lionel Larue (Author), Dorothy Bennett (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781405179546, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 23 April 2010\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e320 pages\u003cbr\u003e24.9 x 19.3 x 2 cm, 0.907 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eServing the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma and more, this new book showcases a blend of new technologies and new insights in the field of pigmantary genetics of mice, with comparative information on other animals. Graduate students can learn here the terminology and scope of the field, and animal fanciers can discover the genetics behind common color variants of mammals. The book is hailed for being written by four of the premier scientists in the field. These authors aim to present the molecular \/cellular work in the context of phenotype and the interacting functions of genes that direct the development and function of one biological system. For other researchers, the depth of genetic knowledge on the pigmantary system makes it a valuable model for the study of other systems.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eAcknowledgments ix\u003c\/p\u003e \u003cp\u003eStatement regarding the use of pictures x\u003c\/p\u003e \u003cp\u003eStatement regarding nomenclature xii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I INTRODUCTION TO THE PIGMENTARY SYSTEM 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction to the Pigmentary System 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 3\u003c\/p\u003e \u003cp\u003e1.2 Colors of vertebrate animals 4\u003c\/p\u003e \u003cp\u003e1.3 Other pigment cells 12\u003c\/p\u003e \u003cp\u003e1.4 The epidermal melanin unit 12\u003c\/p\u003e \u003cp\u003e1.5 Mammalian hair 13\u003c\/p\u003e \u003cp\u003e1.6 Melanosome biogenesis and translocation 14\u003c\/p\u003e \u003cp\u003e1.7 Melanin 15\u003c\/p\u003e \u003cp\u003e1.8 Hair growth 15\u003c\/p\u003e \u003cp\u003e1.9 Hair growth cycles 17\u003c\/p\u003e \u003cp\u003e1.10 Embryonic development of the pigment cell lineage 18\u003c\/p\u003e \u003cp\u003e1.11 Pigment cells in culture 18\u003c\/p\u003e \u003cp\u003e1.12 Conclusion 19\u003c\/p\u003e \u003cp\u003eAppendix: color loci of the mouse 20\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II THE PIGMENTARY LOCI 49\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Introduction to Mutant Pigmentary Genes 51\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Defects of normal melanocyte development: white spotting and graying with age 51\u003c\/p\u003e \u003cp\u003e2.2 Defects in normal melanosome development: albinism 52\u003c\/p\u003e \u003cp\u003e2.3 Transport of melanosomes to other cells: the ‘dilute’ phenotype 53\u003c\/p\u003e \u003cp\u003e2.4 Pigment-type switching: from eumelanogenesis to pheomelanogenesis 54\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 White Spotting and Progressive Graying 57\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Definitions and general background 58\u003c\/p\u003e \u003cp\u003e3.2 Pigment-cell development: developmental biology 62\u003c\/p\u003e \u003cp\u003e3.3 Cellular signaling pathways for melanocytes 71\u003c\/p\u003e \u003cp\u003e3.4 Pigment phenotypes and the classical white-spotting genes 88\u003c\/p\u003e \u003cp\u003e3.5 The head, heart, ears, and eyes 127\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 ‘Albinism’ and the Failure of Normal Melanosome Development 132\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Background 133\u003c\/p\u003e \u003cp\u003e4.2 The melanosomal matrix 140\u003c\/p\u003e \u003cp\u003e4.3 The enzymes that catalyze melanogenesis 146\u003c\/p\u003e \u003cp\u003e4.4 Membrane proteins that regulate the internal milieu of the melanosome 153\u003c\/p\u003e \u003cp\u003e4.5 Protein processing and routing to the maturing melanosome 156\u003c\/p\u003e \u003cp\u003e4.6 Melanosome transport 171\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Pigment-Type Switching 177\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 178\u003c\/p\u003e \u003cp\u003e5.2 Yellow phenotypes 184\u003c\/p\u003e \u003cp\u003e5.3 Melanin pigment 189\u003c\/p\u003e \u003cp\u003e5.4 Melanogenesis and the eumelanin\/pheomelanin switch mechanism 190\u003c\/p\u003e \u003cp\u003e5.5 Signaling the switch mechanism at the cellular level 192\u003c\/p\u003e \u003cp\u003e5.6 Yellow genes 194\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III TECHNOLOGY AND RESOURCES 207\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Novel Mouse Pigmentary Mutants Generated by\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGenetic Manipulation 209\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 209\u003c\/p\u003e \u003cp\u003e6.2 Mouse transgenesis: generation of genetically engineered mice 210\u003c\/p\u003e \u003cp\u003e6.3 Coat-color transgenic mice 219\u003c\/p\u003e \u003cp\u003e6.4 The coat-color mutants generated by gene targeting 224\u003c\/p\u003e \u003cp\u003e6.5 Influence of the genetic background 229\u003c\/p\u003e \u003cp\u003e6.6 Conclusions 230\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Other Species and Other Resources 232\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 232\u003c\/p\u003e \u003cp\u003e7.2 Resources 233\u003c\/p\u003e \u003cp\u003e7.3 Other species 235\u003c\/p\u003e \u003cp\u003eReferences 243\u003c\/p\u003e \u003cp\u003eIndex 286\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biology, life sciences [\u003ca title=\"See our other books on Biology, life sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biology,%20life%20sciences%20%5BPS%5D%22\"\u003ePS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Brand 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