{"product_id":"the-chemistry-and-biology-of-nitroxyl-hno-hardback-9780128009345","title":"The Chemistry and Biology of Nitroxyl (HNO) (Hardback) 9780128009345","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eThe Chemistry and Biology of Nitroxyl (HNO)\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003eProvides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eFabio Doctorovich (Edited by), Patrick J. Farmer (Edited by), Marcelo A. Marti (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128009345\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 5 September 2016\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e424 pages\u003cbr\u003e22.9 x 15.1 x 2.7 cm, 0.81 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eThe Chemistry and Biology of Nitroxyl (HNO)\u003c\/i\u003e provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity.\u003c\/p\u003e \u003cp\u003eThis useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical); biology (molecular, cellular, physiological, and enzymology); pharmacy; and medicine.\u003c\/p\u003e \u003cp\u003eThis book begins by exploring the unique molecule’s structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, before discussing chemical and biological sources of nitroxyl. Advanced chapters discuss methods for both trapping and detecting nitroxyl by spectroscopy, electrochemistry, and fluorescent inorganic cellular probing.\u003c\/p\u003e \u003cp\u003eExpanding on the compound’s foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e1. HNO: Redox Chemistry and Interactions With Small Inorganic Molecules\u003c\/p\u003e \u003cp\u003e2. HNO Donors: Angeli’s Salt and Related Diazeniumdiolates\u003c\/p\u003e \u003cp\u003e3. Hydroxylamines With Organic-Based Leaving Groups as HNO Donors\u003c\/p\u003e \u003cp\u003e4. Mechanistic Aspects of HNO Production from Hydroxylamine and Derivatives\u003c\/p\u003e \u003cp\u003e5. HNO Generation From NO, Nitrite, Inorganic or Organic Nitrosyls, and Crosstalk With H\u003csub\u003e2\u003c\/sub\u003eS\u003c\/p\u003e \u003cp\u003e6. HNO–Thiol Relationship\u003c\/p\u003e \u003cp\u003e7. Non-Heme Transition Metal Complexes of HNO\u003c\/p\u003e \u003cp\u003e8. The Interaction of HNO With Transition Metal Centers and Its Biological Significance. Insight Into Electronic Structure From Theoretical Calculations\u003c\/p\u003e \u003cp\u003e9. Interactions of HNO With Metallated Porphyrins, Corroles, and Corrines\u003c\/p\u003e \u003cp\u003e10. Fluorescent Probes for HNO Detection\u003c\/p\u003e \u003cp\u003e11. Phosphine-Based HNO Detection\u003c\/p\u003e \u003cp\u003e12. Electrochemical Detection of Azanone\u003c\/p\u003e \u003cp\u003e13. Detection of HNO by Membrane Inlet Mass Spectrometry\u003c\/p\u003e \u003cp\u003e14. Spectroscopic NMR Characterizations of HNO Adducts of Ferrous Heme Proteins\u003c\/p\u003e \u003cp\u003e15. Global Kinetic Analysis and Singular Value Decomposition Methods Applied to Complex Multicomponent Reactions of HNO\u003c\/p\u003e \u003cp\u003e16. HNO as an Oxygen Substitute in Enzymes\u003c\/p\u003e \u003cp\u003e17. The Reactions of HNO With Nonheme Proteins: An Emphasis on Thiol-Containing Proteins\u003c\/p\u003e \u003cp\u003e18. Is Azanone Endogenously Produced in Mammals?\u003c\/p\u003e \u003cp\u003e19. From Heaven to Heart: Nitroxyl (HNO) in the Cardiovascular System and Beyond\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biochemistry [\u003ca title=\"See our other books on Biochemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemistry%20%5BPSB%5D%22\"\u003ePSB\u003c\/a\u003e], Inorganic chemistry [\u003ca title=\"See our other books on Inorganic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Inorganic%20chemistry%20%5BPNK%5D%22\"\u003ePNK\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649453117720,"sku":"9780128009345","price":109.75,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128009345_4627c85e-c645-4e09-b7ea-40499204f991.jpg?v=1694353050","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/the-chemistry-and-biology-of-nitroxyl-hno-hardback-9780128009345","provider":"Freshly Printed Books","version":"1.0","type":"link"}