{"product_id":"the-biostatistics-of-aging-from-gompertzian-mortality-to-an-index-of-aging-relatedness-hardback-9781118645857","title":"The Biostatistics of Aging; From Gompertzian Mortality to an Index of Aging-Relatedness (Hardback) 9781118645857","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eThe Biostatistics of Aging\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eFrom Gompertzian Mortality to an Index of Aging-Relatedness\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eGilberto Levy (Author), Bruce Levin (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781118645857, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 9 May 2014\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e272 pages\u003cbr\u003e24.1 x 16 x 2.3 cm, 0.576 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eA practical and clarifying approach to aging and aging-related diseases\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eProviding a thorough and extensive theoretical framework, \u003ci\u003eThe Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness\u003c\/i\u003e addresses the surprisingly subtlenotion—with consequential biomedical and public health relevance—of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population.\u003c\/p\u003e \u003cp\u003eWith input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eOriginal results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme values\u003c\/li\u003e \u003cli\u003eA comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populations\u003c\/li\u003e \u003cli\u003eThe development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiology\u003c\/li\u003e \u003cli\u003eAn explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principles\u003c\/li\u003e \u003cli\u003eThe amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical software\u003c\/li\u003e \u003cli\u003eTechnical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseases\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eThe Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness\u003c\/i\u003e is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003ePREFACE AND ACKNOWLEDGMENT ix\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 An Account of Gompertzian Mortality through Statistical and Evolutionary Arguments 6\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 The Statistical Theory of Extreme Values 10\u003c\/p\u003e \u003cp\u003e2.2 The Evolutionary Theory of Aging 36\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 The Argument against Gompertzian Mortality 69\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Departures from the Gompertz Model 70\u003c\/p\u003e \u003cp\u003e3.2 An Evolution-Based Model of Causation 72\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The Index of Aging-Relatedness 93\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 A Survival Mixture Model of the Gompertz and Weibull Distributions 94\u003c\/p\u003e \u003cp\u003e4.2 Definition and Interpretation of the Index of Aging-Relatedness 97\u003c\/p\u003e \u003cp\u003e4.3 The Survival Mixture Model and Competing Risks 103\u003c\/p\u003e \u003cp\u003e4.4 Estimation of the Model Parameters 107\u003c\/p\u003e \u003cp\u003e4.5 Illustrative Application: The Israeli Ischemic Heart Disease Study 109\u003c\/p\u003e \u003cp\u003e4.6 Precision of Estimation 122\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Discussion: Implications 128\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 The Meaning of the Gompertz Parameter 128\u003c\/p\u003e \u003cp\u003e5.2 Age as a Risk Factor for Disease 132\u003c\/p\u003e \u003cp\u003e5.3 Are Aging-Related Diseases an Integral Part of Aging? 134\u003c\/p\u003e \u003cp\u003e5.4 Biological versus Chronological Aging 135\u003c\/p\u003e \u003cp\u003e5.5 The Public Health Notion of Compression of Morbidity 138\u003c\/p\u003e \u003cp\u003e5.6 A Picture of Aging for the Twenty-First Century 143\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX A: PROOFS OF RESULTS IN SECTION 2.1.2 WITH SOME EXTENSIONS 154\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX B: DERIVATION OF HAMILTON’S EQUATION FOR THE FORCE OF NATURAL SELECTION ON MORTALITY 170\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX C: SOME PROPERTIES OF THE GOMPERTZ AND WEIBULL DISTRIBUTIONS 174\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX D: FIRST AND SECOND PARTIAL DERIVATIVES OF THE MIXTURE LOG-LIKELIHOOD FUNCTION 178\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX E: EXPECTATION–CONDITIONAL MAXIMIZATION (ECM) ALGORITHM 183\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAPPENDIX F: R PROGRAM 190\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eREFERENCES 226\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAUTHOR INDEX 245\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSUBJECT INDEX 253\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Mathematics [\u003ca title=\"See our other books on Mathematics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Mathematics%20%5BPB%5D%22\"\u003ePB\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52417795096856,"sku":"9781118645857","price":85.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781118645857.jpg?v=1784509642","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/the-biostatistics-of-aging-from-gompertzian-mortality-to-an-index-of-aging-relatedness-hardback-9781118645857","provider":"Freshly Printed Books","version":"1.0","type":"link"}