{"product_id":"the-biology-of-extracellular-molecular-chaperones-hardback-9780470723333","title":"The Biology of Extracellular Molecular Chaperones (Hardback) 9780470723333","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eThe Biology of Extracellular Molecular Chaperones\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eDerek J. Chadwick (Edited by), Novartis Founda (Author), Jamie A. Goode (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470723333, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 14 March 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e248 pages\u003cbr\u003e23.2 x 16 x 1.7 cm, 0.539 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"This is a useful addition to the literature on chaperones … .It provides an excellent source of information for anyone who needs more than just basic knowledge about this area of biology.\" (\u003ci\u003eDoodys Book Reviews\u003c\/i\u003e, December 2008)\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe heat shock, or cell stress, response was first identified in the polytene chromosomes of \u003ci\u003eDrosophila\u003c\/i\u003e. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses.  \u003cp\u003eSince the promulgation of the ‘molecular chaperone’ concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized that not all molecular chaperones are stress proteins and vice versa. The discovery of molecular chaperones as folding proteins went hand-in-hand with their recognition as potent immunogens in microbial infection. It was subsequently shown that administration of molecular chaperones such as Hsp60, Hsp70 or Hsp90 could inhibit experimental autoimmune diseases and cancer.\u003c\/p\u003e \u003cp\u003eMore recently evidence has accumulated to show that certain molecular chaperones are also present on the surface of cells or in extracellular fluids. A new paradigm is emerging: at least some molecular chaperones are secreted proteins with pro- or anti-inflammatory actions, regulating the immune response in human diseases such as coronary heart disease, diabetes and rheumatoid arthritis. In addition to having direct effects on cells, molecular chaperones can bind peptides and present them to T cells to modulate immune responses. This may be significant in the treatment of cancer.\u003c\/p\u003e \u003cp\u003eThis is the first book bringing leading researchers in this field together to review and discuss:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003eour current knowledge of cell stress response and molecular chaperones\u003c\/li\u003e \u003cli\u003ethe changing paradigms of protein trafficking and function\u003c\/li\u003e \u003cli\u003ecell stress proteins as immunomodulators and pro- and anti-inflammatory signalling molecules\u003c\/li\u003e \u003cli\u003ethe role of these proteins in various chronic diseases and their potential as preventative or therapeutic agents.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eThe Biology of Extracellular Molecular Chaperones\u003c\/i\u003e is of particular interest to immunologists, cell and molecular biologists, microbiologists and virologists, as well as clinical researchers working in cardiology, diabetes, rheumatoid arthritis and other inflammatory diseases.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eSymposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5–7 June 2007\u003c\/i\u003e.  \u003cp\u003e\u003ci\u003eEditors: Derek J. Chadwick (Organizer) and Jamie Goode\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eThis symposium is based on a proposal made by Brian Henderson, R. John Ellis and A. Graham Pockley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePéter Csermely\u003c\/b\u003e Chair's introduction.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJodie Haak\u003c\/b\u003e and \u003cb\u003eKevin C. Kregel\u003c\/b\u003e 1962–2007: a cell stress odyssey.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePeter A. Lund\u003c\/b\u003e and \u003cb\u003eR. John Ellis\u003c\/b\u003e The chaperone function: meanings and myths.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePéter Csermely, Tamás Korcsmáros, István A. Kovács, Máté S. Szalay\u003c\/b\u003e and \u003cb\u003eCsaba Soti\u003c\/b\u003e Systems biology of molecular chaperone networks.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRadhey S. Gupta , Nallur B. Ramachandra, Timothy Bowes\u003c\/b\u003e and \u003cb\u003eBhag Singh\u003c\/b\u003e Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMartha Triantafilou, Daniel Sawyer, Abdiaziz Nor,\u003c\/b\u003e \u003cb\u003eEmmanouil Vakakis\u003c\/b\u003e and \u003cb\u003eKathy Triantafilou\u003c\/b\u003e Cell surface molecular chaperones as endogenous modulators of the innate immune response.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eA. Graham Pockley\u003c\/b\u003e and \u003cb\u003eGabriele Multhoff\u003c\/b\u003e Cell stress proteins in extracellular fluids: friend or foe?\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFrancisco J. Quintana\u003c\/b\u003e and \u003cb\u003eIrun R. Cohen\u003c\/b\u003e HSP60 speaks to the immune system in many voices.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eStuart K. Calderwood, Jianlin Gong, Jimmy R. Theriault,\u003c\/b\u003e \u003cb\u003eSalamatu S. Mambula\u003c\/b\u003e and \u003cb\u003ePhilip J. Gray Jnr\u003c\/b\u003e Cell stress proteins: novel immunotherapeutics.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGeneral discussion\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eBrian Henderson\u003c\/b\u003e Cell stress proteins as modulators of bacteria–host interactions.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAnthony R. M. Coates, Ana Cehovin\u003c\/b\u003e and \u003cb\u003eYanmin Hu\u003c\/b\u003e Chaperonin 60 and macrophage activation.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAlexzander Asea\u003c\/b\u003e Hsp70: a chaperokine.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eHajime Nakamura\u003c\/b\u003e Extracellular functions of thioredoxin.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCarol L. Miller-Graziano, Asit De, Krzysztof Laudanski,\u003c\/b\u003e \u003cb\u003eTara Herrmann\u003c\/b\u003e and \u003cb\u003eSanjukta Bandyopadhyay\u003c\/b\u003e HSP27: an anti-inflammatory and immunomodulatory stress protein acting to dampen immune function.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGabriel S. Panayi\u003c\/b\u003e and \u003cb\u003eValerie M. Corrigall\u003c\/b\u003e BiP, an anti-inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFinal discussion\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003eIndex of contributors.\u003c\/p\u003e \u003cp\u003eSubject index.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biology, life sciences [\u003ca title=\"See our other books on Biology, life sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biology,%20life%20sciences%20%5BPS%5D%22\"\u003ePS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52278024372504,"sku":"9780470723333","price":143.56,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470723333.jpg?v=1781456117","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/the-biology-of-extracellular-molecular-chaperones-hardback-9780470723333","provider":"Freshly Printed Books","version":"1.0","type":"link"}