{"product_id":"telomeres-chromosome-sentinels-hardback-9781789450972","title":"Telomeres; Chromosome Sentinels (Hardback) 9781789450972","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eTelomeres\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eChromosome Sentinels\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eCarole Saintome (Edited by), Saintomé (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781789450972, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 22 September 2024\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e400 pages\u003cbr\u003e23.5 x 15.6 x 2.5 cm, 0.794 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eTelomeres are specialized DNA–protein structures that protect the ends of chromosomes to maintain their integrity. They are chromosome sentinels. This book, written by multiple authors, presents current knowledge and the most recent discoveries relating to telomeres.\u003c\/p\u003e \u003cp\u003eThe first chapters describe telomere structures (DNA and proteins), organization, dynamics and replication in a range of organisms including ciliates, yeast and mammals. The following chapters cover mechanisms that maintain telomere length involving telomerase and Alternative Lengthening Telomeres (ALT) mechanisms. Interestingly, telomeres are transcribed into repetitive RNA called TERRA (Telomeric repeat-containing RNA), the state of the art regarding mammalian telomere transcripts is presented here.\u003c\/p\u003e \u003cp\u003eTwo chapters are dedicated to the description of how telomere biology impacts the development of cancer and how their disfunctions induce telomeropathies (telomere biology disorders). Finally, the book ends with a chapter presenting telomere and telomerase targeting agents as potential anticancer agents, a promising therapeutic approach.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eForeword xiii\u003cbr\u003e\u003ci\u003eJulia COOPER\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1 Telomeres: All's Well That Ends Well 1\u003c\/b\u003e\u003cbr\u003e\u003ci\u003ePatrizia ALBERTI\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 The beginning of the end 2\u003c\/p\u003e \u003cp\u003e1.3 Telomeric architectures: from ciliates to other eukaryotes 10\u003c\/p\u003e \u003cp\u003e1.4 G-quadruplexes at telomeres 18\u003c\/p\u003e \u003cp\u003e1.5 References 26\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2 Methods to Measure Telomere Lengths 39\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eLauréline ROGER\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Why does telomere length matter? 39\u003c\/p\u003e \u003cp\u003e2.2 Methods for measuring telomere length 41\u003c\/p\u003e \u003cp\u003e2.3 References 53\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3 The Shelterin Complex 57\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eClaire GHILAIN, Eric GILSON and Marie-Josèphe GIRAUD-PANIS\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 TRF1 and TRF2, structurally alike but… 59\u003c\/p\u003e \u003cp\u003e3.2 RAP1 75\u003c\/p\u003e \u003cp\u003e3.3 TIN2 79\u003c\/p\u003e \u003cp\u003e3.4 TPP1-POT1 82\u003c\/p\u003e \u003cp\u003e3.5 Quaternary structure of the shelterin 86\u003c\/p\u003e \u003cp\u003e3.6 Concluding remarks 86\u003c\/p\u003e \u003cp\u003e3.7 References 87\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4 Mammalian Telomere Organization and Dynamics in the Nuclear Volume 105\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSonia STINUS and Laure CRABBE\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 105\u003c\/p\u003e \u003cp\u003e4.2 Nuclear envelope and lamins: orchestrators of cell and genome architecture 106\u003c\/p\u003e \u003cp\u003e4.3 Interplay between telomeres and nuclear structures 108\u003c\/p\u003e \u003cp\u003e4.4 Telomere tethering to the NE to promote meiotic pairing 109\u003c\/p\u003e \u003cp\u003e4.5 Telomere organization and dynamics in the nucleus 110\u003c\/p\u003e \u003cp\u003e4.6 Interaction between telomere chromatin and lamins during post-mitotic nuclear assembly 111\u003c\/p\u003e \u003cp\u003e4.7 Interaction between telomere chromatin and lamins for telomere maintenance 112\u003c\/p\u003e \u003cp\u003e4.8 Conclusion 113\u003c\/p\u003e \u003cp\u003e4.9 References 114\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5 Saccharomyces cerevisiae, a Model at the Forefront of Telomere Biology 119\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAurélia BARASCU and Maria Teresa TEIXEIRA\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 119\u003c\/p\u003e \u003cp\u003e5.2 Telomere characterization: various experimental organisms for first historical experiments 121\u003c\/p\u003e \u003cp\u003e5.3 Protection and proliferation: the telomere dilemma 122\u003c\/p\u003e \u003cp\u003e5.4 Telomere maintenance 129\u003c\/p\u003e \u003cp\u003e5.5 Telomeres: one size for one identity 134\u003c\/p\u003e \u003cp\u003e5.6 Telomeres, replicative senescence, aging and genomic instability 136\u003c\/p\u003e \u003cp\u003e5.7 Senescence escape phenomena and genomic instability 140\u003c\/p\u003e \u003cp\u003e5.8 Conclusion 142\u003c\/p\u003e \u003cp\u003e5.9 References 142\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6 Dealing with Replication Stress at Telomeres 157\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eStéphane COULON\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 157\u003c\/p\u003e \u003cp\u003e6.2 Removal of the DNA structures that impede RF progression 162\u003c\/p\u003e \u003cp\u003e6.3 Accessory factors that contribute to telomere replication l 171\u003c\/p\u003e \u003cp\u003e6.4 Concluding remarks 176\u003c\/p\u003e \u003cp\u003e6.5 References 177\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7 A Brief History of Telomerase: Exceptional Women in Command 193\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eVincent GÉLI\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Acknowledgments 199\u003c\/p\u003e \u003cp\u003e7.2 References 199\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8 Telomerase: Structure and Mechanism 205\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eCarole SAINTOMÉ\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 205\u003c\/p\u003e \u003cp\u003e8.2 Roles 206\u003c\/p\u003e \u003cp\u003e8.3 Structures 207\u003c\/p\u003e \u003cp\u003e8.4 Biogenesis 212\u003c\/p\u003e \u003cp\u003e8.5 Mechanism 214\u003c\/p\u003e \u003cp\u003e8.6 Regulation 215\u003c\/p\u003e \u003cp\u003e8.7 Disease and therapy 216\u003c\/p\u003e \u003cp\u003e8.8 Conclusion 216\u003c\/p\u003e \u003cp\u003e8.9 References 217\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 9 Alternative Lengthening of Telomeres 223\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMathilde GAUCHIER\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 ALT cell markers 224\u003c\/p\u003e \u003cp\u003e9.2 ALT mechanisms 228\u003c\/p\u003e \u003cp\u003e9.3 Replicative stress and DNA repair pathway at ALT telomeres 229\u003c\/p\u003e \u003cp\u003e9.4 The structure of chromatin at ALT telomeres 230\u003c\/p\u003e \u003cp\u003e9.5 ALT and cancer 232\u003c\/p\u003e \u003cp\u003e9.6 The ALT pathway: a non-pathological function? 232\u003c\/p\u003e \u003cp\u003e9.7 Alternative pathways not involving recombination: evolutionary aspects 233\u003c\/p\u003e \u003cp\u003e9.8 Appendix: experimental methods that allow the identification of the ALT phenotype in human cancer cells 236\u003c\/p\u003e \u003cp\u003e9.9 References 237\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 10 TERRA, Telomeric Non-coding RNAs 245\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAnabelle DECOTTIGNIES\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 245\u003c\/p\u003e \u003cp\u003e10.2 The human TERRAs 246\u003c\/p\u003e \u003cp\u003e10.3 The mouse TERRAs 255\u003c\/p\u003e \u003cp\u003e10.4 Conclusion 258\u003c\/p\u003e \u003cp\u003e10.5 References 258\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 11 Telomeres and Cancer 263\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eArturo LONDOÑO-VALLEJO\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 263\u003c\/p\u003e \u003cp\u003e11.2 Short telomeres and telomere-induced senescence are barriers to oncogenic development 264\u003c\/p\u003e \u003cp\u003e11.3 Excessive shortening of telomeres promotes CIN in the early stages of cancer transformation 267\u003c\/p\u003e \u003cp\u003e11.4 The contribution of telomere-driven CIN to tumor progression 270\u003c\/p\u003e \u003cp\u003e11.5 The senescent microenvironment promotes cancer development 271\u003c\/p\u003e \u003cp\u003e11.6 Mechanisms of cell immortalization 273\u003c\/p\u003e \u003cp\u003e11.7 Therapeutic potential of telomeres and telomerase and prognostic value of telomere-related evaluations 277\u003c\/p\u003e \u003cp\u003e11.8 Conclusion 279\u003c\/p\u003e \u003cp\u003e11.9 Acknowledgments 279\u003c\/p\u003e \u003cp\u003e11.10 References 280\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 12 Physiopathology of Telomeres 291\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eCaroline KANNENGIESSER and Patrick REVY\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 291\u003c\/p\u003e \u003cp\u003e12.2 Telomere length in blood 292\u003c\/p\u003e \u003cp\u003e12.3 Different genes associated with telomere defects 295\u003c\/p\u003e \u003cp\u003e12.4 Different diseases associated with telomere defects 300\u003c\/p\u003e \u003cp\u003e12.5 Genetic analysis and counseling 308\u003c\/p\u003e \u003cp\u003e12.6 Treatment of diseases associated with telomere defects 310\u003c\/p\u003e \u003cp\u003e12.7 Compensatory somatic mutations in the TERT promoter 311\u003c\/p\u003e \u003cp\u003e12.8 Missing heredity 312\u003c\/p\u003e \u003cp\u003e12.9 Conclusion 313\u003c\/p\u003e \u003cp\u003e12.10 References 313\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 13 Telomeres Targeting Agents 329\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSophie BOMBARD, Patrick MAILLIET and Marie-Paule TEULADE-FICHOU\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 329\u003c\/p\u003e \u003cp\u003e13.2 Chemistry and in vitro properties of G4 ligands targeting telomeres 330\u003c\/p\u003e \u003cp\u003e13.3 Biological properties of G4 ligands targeting telomeres 341\u003c\/p\u003e \u003cp\u003e13.4 Metal complexes targeting telomeres 344\u003c\/p\u003e \u003cp\u003e13.5 Compounds targeting the proteins of the human shelterin complex 348\u003c\/p\u003e \u003cp\u003e13.6 Compounds targeting telomerase 355\u003c\/p\u003e \u003cp\u003e13.7 General conclusion 357\u003c\/p\u003e \u003cp\u003e13.8 Acknowledgments 358\u003c\/p\u003e \u003cp\u003e13.9 References 358\u003c\/p\u003e \u003cp\u003eList of Authors 373\u003c\/p\u003e \u003cp\u003eIndex 377\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biology, life sciences [\u003ca title=\"See our other books on Biology, life sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biology,%20life%20sciences%20%5BPS%5D%22\"\u003ePS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-ISTE","offers":[{"title":"Brand New","offer_id":52446814044440,"sku":"9781789450972","price":111.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781789450972.jpg?v=1785114507","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/telomeres-chromosome-sentinels-hardback-9781789450972","provider":"Freshly Printed Books","version":"1.0","type":"link"}