{"product_id":"telomerases-chemistry-biology-and-clinical-applications-hardback-9780470592045","title":"Telomerases; Chemistry, Biology, and Clinical Applications (Hardback) 9780470592045","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eTelomerases\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eChemistry, Biology, and Clinical Applications\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eNeal F. Lue (Edited by), N Lue (Author), Chantal Autexier (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470592045, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 27 July 2012\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e318 pages\u003cbr\u003e24.1 x 16.3 x 2.3 cm, 0.611 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThis book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research.  Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase.  Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.\u003cbr\u003e \u003cbr\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003e1 The Telomerase Complex: An Overview 1\u003cbr\u003e \u003ci\u003eJohanna Mancini and Chantal Autexier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Telomerase RNA: Structure, Function, and Molecular Mechanisms 23\u003cbr\u003e \u003ci\u003eYehuda Tzfati and Julian J.-L. Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 TERT Structure, Function, and Molecular Mechanisms 53\u003cbr\u003e \u003ci\u003eEmmanuel Skordalakes and Neal F. Lue\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions 79\u003cbr\u003e \u003ci\u003eTara Beattie and Pascal Chartrand\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Transcriptional Regulation of Human Telomerase 105\u003cbr\u003e \u003ci\u003eAntonella Farsetti and Yu-Sheng Cong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Telomerase Regulation and Telomere-Length Homeostasis 135\u003cbr\u003e \u003ci\u003eJoachim Lingner and David Shore\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Telomere Structure in Telomerase Regulation 157\u003cbr\u003e \u003ci\u003eMomchil D. Vodenicharov and Raymund J. Wellinger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Off-Telomere Functions of Telomerase 201\u003cbr\u003e \u003ci\u003eKenkichi Masutomi and William C. Hahn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Murine Models of Dysfunctional Telomeres and Telomerase 213\u003cbr\u003e \u003ci\u003eYie Liu and Lea Harrington\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Cellular Senescence, Telomerase, and Cancer in Human Cells 243\u003cbr\u003e \u003ci\u003ePhillip G. Smiraldo, Jun Tang, Jerry W. Shay, and Woodring E. Wright\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Telomerase, Retrotransposons, and Evolution 265\u003cbr\u003e \u003ci\u003eIrina R. Arkhipova\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 301\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276367524120,"sku":"9780470592045","price":93.39,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470592045.jpg?v=1781367771","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/telomerases-chemistry-biology-and-clinical-applications-hardback-9780470592045","provider":"Freshly Printed Books","version":"1.0","type":"link"}