{"product_id":"systems-biology-in-drug-discovery-and-development-hardback-9780470261231","title":"Systems Biology in Drug Discovery and Development (Hardback) 9780470261231","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eSystems Biology in Drug Discovery and Development\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eDaniel L. Young (Author), Seth Michelson (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470261231, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 18 November 2011\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e380 pages\u003cbr\u003e24.4 x 16.3 x 2.5 cm, 0.699 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e“I enjoyed reading this book as it should be essential reading for those involved in drug discovery and development for all others who share an interest in this field.”  (\u003ci\u003eInternational Society for the Study of Xenobiotics\u003c\/i\u003e, 2012)\u003c\/p\u003e \u003cp\u003e\"In short, this is an indispensable tool for both experienced and early stage investigators and others to understand the current and future impact of systems biology on the drug discovery and development process.\" (Doody's, 6 January 2012)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe first book to focus on comprehensive systems biology as applied to drug discovery and development  \u003cp\u003eDrawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries.\u003c\/p\u003e \u003cp\u003eThe first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification.\u003c\/p\u003e \u003cp\u003eIntroducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cb\u003ePart I: Introduction to Systems Biology Approach.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eChapter 1. Introduction to systems biology in drug discovery and development.\u003c\/b\u003e\u003cbr\u003e 1.1 Introduction.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2. Methods for In Silico Biology: Model Construction and Analysis.\u003c\/b\u003e\u003cbr\u003e 2.1 Introduction.\u003cbr\u003e 2.2 Model building.\u003cbr\u003e 2.3 Parameter estimation.\u003cbr\u003e 2.4. Model analysis.\u003cbr\u003e 2.5 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3. Methods in In Silico Biology: Modeling Feedback Dynamics in Pathways.\u003c\/b\u003e\u003cbr\u003e 3.1 Introduction.\u003cbr\u003e 3.2 Statistical modeling.\u003cbr\u003e 3.3 Mathematical modeling.\u003cbr\u003e 3.4 Feedback and feedforward.\u003cbr\u003e 3.5 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4. Simulation of Population Variability in Pharmacokinetics.\u003c\/b\u003e\u003cbr\u003e 4.1 Introduction.\u003cbr\u003e 4.2 PBPK modeling.\u003cbr\u003e 4.3 Simulation of pharmacokinetic variability.\u003cbr\u003e 4.4 Conclusions and future directions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Applications to Drug Discovery.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5. Applications of Systems Biology Approaches to Target Identification and Validation in Drug Discovery.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction.\u003cbr\u003e 5.2 Typical drug discovery paradigm.\u003cbr\u003e 5.3 Integrated drug discovery.\u003cbr\u003e 5.4 Drivers of the disease phenotype: clinical endpoints and hypotheses.\u003cbr\u003e 5.5 Extracellular disease drivers: mechanistic biotherapeutic models.\u003cbr\u003e 5.6 Relevant cell models for clinical endpoints.\u003cbr\u003e 5.7 Intracellular disease drivers: signaling pathway quantification.\u003cbr\u003e 5.8 Target selection: dynamic pathway modeling.\u003cbr\u003e 5.9 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6. Lead Identification and Optimization.\u003c\/b\u003e\u003cbr\u003e 6.1 Introduction.\u003cbr\u003e 6.2 The systems biology toolkit.\u003cbr\u003e 6.3 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7. The role of core biological motifs in dose-response modeling: an example with switch-like circuits.\u003c\/b\u003e\u003cbr\u003e 7.1 Introduction: systems perspective in drug discovery.\u003cbr\u003e 7.2 Systems biology and toxicology.\u003cbr\u003e 7.3 Mechanistic\/computational concepts in a molecular\/cellular context.\u003cbr\u003e 7.4 Response motifs in cell signaling and their role in dose response.\u003cbr\u003e 7.5 Discussion and conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8. Mechanism Based Pharmacokinetic-Pharmacodynamic Modeling During Discovery and Early Development.\u003c\/b\u003e\u003cbr\u003e 8.1 Introduction.\u003cbr\u003e 8.2 Challenges in drug discovery and development: the need to bring together PK and PD.\u003cbr\u003e 8.3 Methodological aspects and concepts.\u003cbr\u003e 8.4 Application during lead optimization.\u003cbr\u003e 8.5 Application during clinical candidate selection.\u003cbr\u003e 8.6 Entry into human (EIH) preparation and translational PK\/PD modeling.\u003cbr\u003e 8.7 PK\/PD for toxicology study design and evaluation.\u003cbr\u003e 8.8 Justification of starting dose, calculation of safety margins, and support of phase I design.\u003cbr\u003e 8.9 Phase I and beyond.\u003cbr\u003e 8.10 Support of early formulation development.\u003cbr\u003e 8.11 Outlook and conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III: Applications to Drug Development.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 9. Developing Oncology Drugs Using Virtual Patients of Vascular Tumor Diseases.\u003c\/b\u003e\u003cbr\u003e 9.1 Introduction.\u003cbr\u003e 9.2 Modeling angiogenesis.\u003cbr\u003e 9.3 Use of rigorous mathematical analysis for gaining insight on drug development.\u003cbr\u003e 9.4 Use of angiogenesis models in theranostics.\u003cbr\u003e 9.5 Use of angiogenesis models in drug salvage: the virtual patient technology.\u003cbr\u003e 9.6 Summary and conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 10. Systems Modeling Applied to Candidate Biomarker Identification.\u003c\/b\u003e\u003cbr\u003e 10.1 Introduction.\u003cbr\u003e 10.2 Biomarker discovery approaches.\u003cbr\u003e 10.3 Examples of systems modeling approaches for identification of candidate biomarkers.\u003cbr\u003e 10.4 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 11. Simulating Clinical Trials.\u003c\/b\u003e\u003cbr\u003e 11.1 Introduction.\u003cbr\u003e 11.2 Types of models used in clinical trial design.\u003cbr\u003e 11.3 Sources of prior information for designing clinical trials.\u003cbr\u003e 11.4 Aspects of a trial to be designed and optimized.\u003cbr\u003e 11.5 Trial simulation.\u003cbr\u003e 11.6 Optimizing designs.\u003cbr\u003e 11.7 Real world examples.\u003cbr\u003e 11.8 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV: Synergies with other technologies.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 12. Pathway Analysis in Drug Discovery.\u003c\/b\u003e\u003cbr\u003e 12.1 Introduction: pathway analysis, dynamic modeling, and network analysis.\u003cbr\u003e 12.2 Software systems for pathway analysis.\u003cbr\u003e 12.3 Pathway analysis in modern drug development pipeline.\u003cbr\u003e 12.4 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 13. Functional mapping for predicting drug response and enabling personalized medicine.\u003c\/b\u003e\u003cbr\u003e 13.1 Introduction.\u003cbr\u003e 13.2 Functional mapping.\u003cbr\u003e 13.3 Predictive modeling.\u003cbr\u003e 13.4 Future directions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 14. Future Outlook of Systems Biology.\u003c\/b\u003e\u003cbr\u003e 14.1 Introduction.\u003cbr\u003e 14.2 Systems complexity in biological systems.\u003cbr\u003e 14.3 Models for quantitative integration of data.\u003cbr\u003e 14.4 Changing requirements for systems approaches during drug discovery and development.\u003cbr\u003e 14.5 Better models for better decisions.\u003cbr\u003e 14.6 Advancing personalized medicine.\u003cbr\u003e 14.7 Improving clinical trials and enabling more complex treatment approaches.\u003cbr\u003e 14.8 Collaboration and training for systems biologists.\u003cbr\u003e 14.9 Conclusions.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276158923032,"sku":"9780470261231","price":79.88,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470261231.jpg?v=1781364615","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/systems-biology-in-drug-discovery-and-development-hardback-9780470261231","provider":"Freshly Printed Books","version":"1.0","type":"link"}