{"product_id":"structure-and-function-of-the-extracellular-matrix-a-multiscale-quantitative-approach-paperback-9780128197165","title":"Structure and Function of the Extracellular Matrix; A Multiscale Quantitative Approach (Paperback) 9780128197165","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eStructure and Function of the Extracellular Matrix\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eA Multiscale Quantitative Approach\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eIntegrates evolutionary biology with multiscale structure to quantitatively explain the function of the extracellular matrix in health and disease\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eBela Suki (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128197165, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 8 December 2021\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e282 pages, 100 illustrations (50 in full color)\u003cbr\u003e23.5 x 19 x 1.9 cm, 0.73 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eStructure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach\u003c\/i\u003e introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties.  \u003c\/p\u003e  \u003cp\u003eThis book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki’s book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eDefinition of symbols xi\u003c\/p\u003e \u003cp\u003e1. Introduction to structure-function relationships\u003c\/p\u003e \u003cp\u003eWhat is structure? 1\u003c\/p\u003e \u003cp\u003eWhat is function? 1\u003c\/p\u003e \u003cp\u003eWhat are structure-function relations? 2\u003c\/p\u003e \u003cp\u003eThe multiscale nature of structure-function relations 3\u003c\/p\u003e \u003cp\u003eEvolutionary aspects 4\u003c\/p\u003e \u003cp\u003eImplications for science and medicine 5\u003c\/p\u003e \u003cp\u003eReferences 6\u003c\/p\u003e \u003cp\u003e2. Extracellular matrix background material: Building blocks, general structure, mechanics, relation to cells, and evolutionary aspects\u003c\/p\u003e \u003cp\u003eThe building blocks and the structure of proteins 9\u003c\/p\u003e \u003cp\u003eGeneral properties and organization of the ECM 11\u003c\/p\u003e \u003cp\u003eMechanical forces, stresses, and stiffness 14\u003c\/p\u003e \u003cp\u003eRelation of the ECM to cells 19\u003c\/p\u003e \u003cp\u003eECM and evolution 21\u003c\/p\u003e \u003cp\u003eReferences 25\u003c\/p\u003e \u003cp\u003e3. The collagen molecule\u003c\/p\u003e \u003cp\u003eCollagen classification 29\u003c\/p\u003e \u003cp\u003eA brief evolutionary history of the collagen family 31\u003c\/p\u003e \u003cp\u003eStructure of the collagen molecule 33\u003c\/p\u003e \u003cp\u003eBiosynthesis 35\u003c\/p\u003e \u003cp\u003eCollagen functions 36\u003c\/p\u003e \u003cp\u003eCollagen binding properties 38\u003c\/p\u003e \u003cp\u003eCollagen elasticity 39\u003c\/p\u003e \u003cp\u003ePolymer-based modeling: The mechanical properties of the molecule 44\u003c\/p\u003e \u003cp\u003eStructural models of the collagen molecule 45\u003c\/p\u003e \u003cp\u003eEffects of mutations on molecular structure and function 49\u003c\/p\u003e \u003cp\u003eReferences 52\u003c\/p\u003e \u003cp\u003e4. Collagen supramolecular structures: Evolution, organization, and biogenesis \u003c\/p\u003e \u003cp\u003eEvolution of the fibril and the diversification of the collagen family 56\u003c\/p\u003e \u003cp\u003eMultiscale nature of fibril structure 59\u003c\/p\u003e \u003cp\u003eNetwork structure of type IV collagen 62\u003c\/p\u003e \u003cp\u003eFibril formation 64\u003c\/p\u003e \u003cp\u003eModeling fibril growth 67\u003c\/p\u003e \u003cp\u003eReferences 73\u003c\/p\u003e \u003cp\u003e5. Collagen suprastructures: The data and the models Structure and function of type IV collagen networks 78\u003c\/p\u003e \u003cp\u003eQuantitative analysis of structure-function relations in the glomerular basement membrane of the kidney 80\u003c\/p\u003e \u003cp\u003eStructure-function of elastic networks from the point of view of percolation: Implications for tissue engineering 85\u003c\/p\u003e \u003cp\u003eMicroscopic structure-function relations of the collagen fibril 88\u003c\/p\u003e \u003cp\u003eMultiscale mechanical properties of the collagen fibril: The data 91\u003c\/p\u003e \u003cp\u003eModeling fibril function: From simple to complex 96\u003c\/p\u003e \u003cp\u003eIs fibril viscoelasticity a signature of hidden complexity? 100\u003c\/p\u003e \u003cp\u003eReferences 108\u003c\/p\u003e \u003cp\u003e6. Selected examples of tissue-level collagen suprastructures: Tendon, bone, and skin\u003c\/p\u003e \u003cp\u003eBasic structure and function of the tendon 113\u003c\/p\u003e \u003cp\u003eModeling the recruitment of wavy fibrils during tendon stretching 114\u003c\/p\u003e \u003cp\u003eModeling tendon rupture 119\u003c\/p\u003e \u003cp\u003eA brief introduction to the evolutionarily shaped structure and function of the bone 120\u003c\/p\u003e \u003cp\u003eExamples of multiscale structure-function relation in bones 123\u003c\/p\u003e \u003cp\u003eThe evolution and basic function of the skin 128\u003c\/p\u003e \u003cp\u003eMultiscale mechanics and tear resistance of the skin 130\u003c\/p\u003e \u003cp\u003eA note on the biological significance of recruitment 136\u003c\/p\u003e \u003cp\u003eReferences 139\u003c\/p\u003e \u003cp\u003e7. Small leucine-rich proteoglycans: The tiny controllers of the extracellular matrix\u003c\/p\u003e \u003cp\u003eBasic structure and evolution of SLRPs 143\u003c\/p\u003e \u003cp\u003eBiological functions of SLRPs 146\u003c\/p\u003e \u003cp\u003eThe PG interaction network 149\u003c\/p\u003e \u003cp\u003ePhysiological functions of SLRPs 151\u003c\/p\u003e \u003cp\u003eInfluence of GAGs on lung parenchymal mechanics 155\u003c\/p\u003e \u003cp\u003eSummary 159\u003c\/p\u003e \u003cp\u003eReferences 159\u003c\/p\u003e \u003cp\u003e8. Hyaluronan and hyalectans: The good, the bad, and the ugly\u003c\/p\u003e \u003cp\u003eEvolutionary history 166\u003c\/p\u003e \u003cp\u003eThe structure of the HA-hyalectan aggregate 167\u003c\/p\u003e \u003cp\u003eBinding and molecular to cellular functions 171\u003c\/p\u003e \u003cp\u003eMicroscale physiological functions 173\u003c\/p\u003e \u003cp\u003eStructure and function of the endothelial glycocalyx 176\u003c\/p\u003e \u003cp\u003ePhysiological functions 179\u003c\/p\u003e \u003cp\u003eThe bad and the ugly 184\u003c\/p\u003e \u003cp\u003eSummary 187\u003c\/p\u003e \u003cp\u003eReferences 188\u003c\/p\u003e \u003cp\u003e9. Elastic fibers: The near ideal linear springs of the extracellular matrix\u003c\/p\u003e \u003cp\u003eEvolution of elastin 194\u003c\/p\u003e \u003cp\u003eThe tropoelastin gene structure 196\u003c\/p\u003e \u003cp\u003eStructure, disorder, and aggregation 197\u003c\/p\u003e \u003cp\u003eMechanical properties of tropoelastin 201\u003c\/p\u003e \u003cp\u003eMicrofibrils 204\u003c\/p\u003e \u003cp\u003eElastogenesis: How to build a network of elastic fibers 206\u003c\/p\u003e \u003cp\u003eElastic fibers: Are they ideal linear springs? 208\u003c\/p\u003e \u003cp\u003eA brief summary on organ-level function and its breakdown 217\u003c\/p\u003e \u003cp\u003eFinal notes on the near ideal spring 219\u003c\/p\u003e \u003cp\u003eReferences 223\u003c\/p\u003e \u003cp\u003e10. Modeling maintenance and repair: The matrix loaded\u003c\/p\u003e \u003cp\u003eEvolution of homeostasis and repair 230\u003c\/p\u003e \u003cp\u003eA continuum approach to ECM growth and remodeling 235\u003c\/p\u003e \u003cp\u003eDynamics of homeostasis and structural remodeling 237\u003c\/p\u003e \u003cp\u003eFluctuation-driven homeostasis 240\u003c\/p\u003e \u003cp\u003eA toy model of self-healing 243\u003c\/p\u003e \u003cp\u003eAgent-based modeling: The network paradigm 245\u003c\/p\u003e \u003cp\u003eThe uninvited aging: Maintenance and repair slipping out of control 249\u003c\/p\u003e \u003cp\u003eWhat have we learned? 250\u003c\/p\u003e \u003cp\u003eReferences 251\u003c\/p\u003e \u003cp\u003e11. Outlook\u003c\/p\u003e \u003cp\u003eIndex 259\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Engineering: general [\u003ca title=\"See our other books on Engineering: general\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Engineering:%20general%20%5BTBC%5D%22\"\u003eTBC\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46648681300248,"sku":"9780128197165","price":103.75,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128197165.jpg?v=1694093297","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/structure-and-function-of-the-extracellular-matrix-a-multiscale-quantitative-approach-paperback-9780128197165","provider":"Freshly Printed Books","version":"1.0","type":"link"}