{"product_id":"stereoselective-synthesis-of-drugs-and-natural-products-2-volume-set-hardback-9781118032176","title":"Stereoselective Synthesis of Drugs and Natural Products, 2 Volume Set (Hardback) 9781118032176","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eStereoselective Synthesis of Drugs and Natural Products, 2 Volume Set\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eVasyl Andrushko (Edited by), V Andrushko (Author), Natalia Andrushko (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781118032176, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 29 November 2013\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1836 pages\u003cbr\u003e31 x 23.6 x 16.5 cm, 6.623 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e“The work will also be very useful to those actively involved in the teaching of modern organic chemistry and synthetic methodologies, because it allows one to quickly compile several examples of applications of methods for a lecture and include details of the corresponding transition states without the need to obtain the original publications.”  (\u003ci\u003eAngew. Chem. Int. Ed\u003c\/i\u003e, 1 May 2014)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eBrings together the best tested and proven stereoselective synthetic methods\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBoth the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of S\u003ci\u003etereoselective Synthesis of Drugs and Natural Products,\u003c\/i\u003e researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStereoselective Synthesis of Drugs and Natural Products\u003c\/i\u003e features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery.\u003c\/p\u003e \u003cp\u003eThe publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e\n\u003cb\u003ePart One:\u003c\/b\u003e \u003ci\u003eGeneral Methods and Strategies\u003c\/i\u003e\n\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003ePart Two:\u003c\/b\u003e \u003ci\u003eStereoselective Synthesis by Bond Formation\u003c\/i\u003e including\u003c\/li\u003e \u003cul\u003e \u003cli\u003eC-C bond formation\u003c\/li\u003e \u003cli\u003eC-H bond formation\u003c\/li\u003e \u003cli\u003eC-O bond formation\u003c\/li\u003e \u003cli\u003eC-N bond formation\u003c\/li\u003e \u003cli\u003eOther C-heteroatom formation and other bond formation\u003c\/li\u003e \u003c\/ul\u003e \u003cli\u003e\n\u003cb\u003ePart Three:\u003c\/b\u003e \u003ci\u003eMethods of Analysis and Chiral Separation\u003c\/i\u003e\n\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eReferences in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface\u003c\/p\u003e \u003cp\u003eList of contributors\u003c\/p\u003e \u003cp\u003eList of symbols and abbreviations\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 1: GENERAL METHODS AND STRATEGIES\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1: Principles, concepts and strategies of stereoselective synthesis\u003cbr\u003e \u003ci\u003eVasyl Andrushko and Natalia Andrushko\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 2: Chiral auxiliaries in drug synthesis\u003cbr\u003e \u003ci\u003eStanley Chang, Shira D. Halperin, Jarod Moore and Robert Britton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 3: Solid-phase organic synthesis of drugs and natural products\u003cbr\u003e \u003ci\u003ePeter J. H. Scott\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 4: Asymmetric phase-transfer catalysis\u003cbr\u003e \u003ci\u003eKohsuke Ohmatsu, Daisuke Uraguchi, and Takashi Ooi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 5: Microwave-assisted stereoselective synthesis\u003cbr\u003e \u003ci\u003eYoann Coquerel, Evelina Colacino, Jean Rodriguez, Jean Martinez and Frédéric Lamaty\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 6: Application of micro reactor methodology for organic synthesis\u003cbr\u003e \u003ci\u003ePaul Watts and Charlotte Wiles\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 2: STEREOSELECTIVE SYNTHESIS BY BOND FORMATION\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1. STEREOSELECTIVE METHODS FOR C–C BOND FORMATION\u003c\/p\u003e \u003cp\u003eChapter 7: Asymmetric α-alkylation of aldehydes, ketones and carboxylic acids\u003cbr\u003e \u003ci\u003eMark C. Kohler, Sarah E. Wengryniuk, and Don M. Coltart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 8: Asymmetric aldol reactions in the total syntheses of natural products\u003cbr\u003e \u003ci\u003eSeijiro Hosokawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 9: Asymmetric Michael addition and related reactions\u003cbr\u003e \u003ci\u003ePengfei Li, Jun Wang and Fuk Yee Kwong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 10: Construction of polypropionate fragments in natural product synthesis\u003cbr\u003e \u003ci\u003eMaris Turks, Sylvain Laclef and Pierre Vogel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 11: Organocatalytic conjugate addition in stereoselective synthesis\u003cbr\u003e \u003ci\u003eAdrien Quintard and Alexandre Alexakis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 12: Stereoselective Nozaki-Hiyama-Kishi reaction\u003cbr\u003e \u003ci\u003ePat Guiry and Gráinne Hargaden\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 13: Transition-metal-catalyzed asymmetric C–C cross-couplings in stereoselective synthesis \u003ci\u003eVasiliki Sarli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 14: Asymmetric hydroformylation, hydroxy- and alkoxycarbonylation for stereoselective synthesis\u003cbr\u003e \u003ci\u003eJamie T. Durrani and Matthew L. Clarke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 15: Intramolecular oxycarbonylation in stereoselective synthesis\u003cbr\u003e \u003ci\u003eTibor Gracza\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 16: Stereoselective cycloaddition reactions\u003cbr\u003e \u003ci\u003eTae-Kyung Lee and Jung-Mo Ahn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 17: Sigmatropic rearrangements in stereoselective synthesis\u003cbr\u003e \u003ci\u003eBrinton Seashore-Ludlow and Peter Somfai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 18: Ring contraction reactions in the total synthesis of biologically active natural products\u003cbr\u003e \u003ci\u003eLuiz F. Silva Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 19: Electrocyclic reactions in stereoselective synthesis\u003cbr\u003e \u003ci\u003eMarcus A. Tius\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 20: Transannular cyclization in natural product total synthesis\u003cbr\u003e \u003ci\u003eJiong Yang and Haoran Xue\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 21: Cascade reactions in stereoselective synthesis\u003cbr\u003e \u003ci\u003eBor-Cherng Hong and Nitin S. Dange\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 22: Sulfur dioxide: a powerful tool for the stereoselective construction of C-C bonds\u003cbr\u003e \u003ci\u003ePierre Vogel, Dean Markovic and Mâris Turks\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 23: Transition metal C-H activation: application to stereoselective synthesis of natural products and drugs\u003cbr\u003e \u003ci\u003eMickaël Jean and Pierre van de Weghe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 24: Metathesis reactions in drug and natural product synthesis\u003cbr\u003e \u003ci\u003eAkio Saito, Yuji Hanzawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 25: Radicals in stereoselective C-C bond formation\u003cbr\u003e \u003ci\u003eJosep Bonjoch, Ben Bradshaw and Faïza Diaba\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 26: Trifluoromethyl (CF3) group insertion methods in stereoselective synthesis\u003cbr\u003e \u003ci\u003eTsutomu Konno\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 27: Stereoselective organocatalyzed C–C bond-forming reactions\u003cbr\u003e \u003ci\u003eKazuo Nagasawa and Koji Yasui\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 28: Enzyme-catalysed stereoselective C–C bond formation reactions in total syntheses\u003cbr\u003e \u003ci\u003eAdeline Ranoux and Ulf Hanefeld\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.2. STEREOSELECTIVE METHODS FOR C–H BOND FORMATION\u003c\/p\u003e \u003cp\u003eChapter 29: Stereoselective hydrogenation of C=C bonds: application to drug and natural product synthesis\u003cbr\u003e \u003ci\u003eNatalia Andrushko and Vasyl Andrushko\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 30: Asymmetric hydrogenation of C=O and C=N bonds in stereoselective synthesis\u003cbr\u003e \u003ci\u003eNatalia Andrushko and Vasyl Andrushko\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 31: Asymmetric protonation of carbanions and polar double bonds: application to total syntheses\u003cbr\u003e \u003ci\u003eThomas Poisson and Shu Kobayashi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 32: Organocatalytic reduction in stereoselective synthesis\u003cbr\u003e \u003ci\u003eFelix Kortmann and Adriaan Minnaard\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 33: Biocatalytic asymmetric reduction of C=O and activated C=C bonds in stereoselective synthesis\u003cbr\u003e \u003ci\u003eTomoko Matsuda, Rio Yamanaka and Kaoru Nakamura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.3. STEREOSELECTIVE METHODS FOR C–O BOND FORMATION\u003c\/p\u003e \u003cp\u003eChapter 34: Transition-metal-catalyzed stereoselective oxidations in drug and natural product synthesis\u003cbr\u003e \u003ci\u003eAlessandro Scarso and Giorgio Strukul\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 35: Asymmetric epoxidation in stereoselective synthesis\u003cbr\u003e \u003ci\u003eZhicai Yang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 36: Biocatalytic asymmetric oxidations in stereoselective synthesis\u003cbr\u003e \u003ci\u003eAnett Schallmey, Pablo Dominguez de Maria and Paula Bracco\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 37: Ether transfer methodology: application to the synthesis of polyketide natural products\u003cbr\u003e \u003ci\u003eEric Stefan and Richard E. Taylor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 38: Stereoselective formation of 2-deoxyglycosidic bonds in biologically active natural products\u003cbr\u003e \u003ci\u003eDaisuke Takahashi and Kazunobu Toshima\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.4. STEREOSELECTIVE METHODS FOR C–N BOND FORMATION\u003c\/p\u003e \u003cp\u003eChapter 39: Asymmetric hydroamination and reductive amination in total synthesis\u003cbr\u003e \u003ci\u003eManas K. Ghorai, Deo Prakash Tiwari and Aditya Bhattacharyya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 40: Carboamination and alkylative cyclization with C-N bond formation in stereoselective syntheses\u003cbr\u003e \u003ci\u003eManas K. Ghorai, Sandipan Halder and Sauvik Samanta\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 41: Cycloadditions with stereoselective C-N bond formation in total syntheses\u003cbr\u003e \u003ci\u003eGuillaume Vincent\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.5. STEREOSELECTIVE FORMATION OF OTHER C–HETEROATOM AND OTHER BONDS\u003c\/p\u003e \u003cp\u003eChapter 42: Stereoselective halogenations\u003cbr\u003e \u003ci\u003eChong Kiat Tan, Yi Zhao, Jing Zhou and Ying-Yeung Yeung\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 43: Stereoselective synthesis of halogenated natural products\u003cbr\u003e \u003ci\u003eTakehiko Yoshimitsu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 44: Asymmetric fluorination methods: application in the stereoselective synthesis of fluorinated drugs\u003cbr\u003e \u003ci\u003eVincent Bizet and Dominique Cahard\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 45: Enzymatic halogenation in stereoselective synthesis\u003cbr\u003e \u003ci\u003eCormac D. Murphy and Benjamin R. Clark\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 46: Stereoselective carbon–sulfur (C–S) bond formation\u003cbr\u003e \u003ci\u003eKyungsoo Oh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 47: Stereoselective methods for carbon-phosphorus (C–P) bond formation\u003cbr\u003e \u003ci\u003eMarcin Kalek and Jacek Stawinski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 48: Transition-metal-catalyzed asymmetric sulfoxidation in drug and natural product synthesis\u003cbr\u003e \u003ci\u003eAlessandro Scarso and Giorgio Strukul\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 3: METHODS OF ANALYSIS AND CHIRAL SEPARATION\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 49: NMR-Spectroscopy in drug and natural product analysis\u003cbr\u003e \u003ci\u003eStanisuaw Witkowski and Iwona Wawer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 50: Determination of enantiomeric purity and absolute configuration by NMR spectroscopy\u003cbr\u003e \u003ci\u003eThomas J. Wenzel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 51: Solid-state NMR spectroscopy in drug design and discovery\u003cbr\u003e \u003ci\u003eDavid A. Middleton and Simon G. Patching\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 52: Capillary electrophoresis in chiral separations\u003cbr\u003e \u003ci\u003eAns Hendrickx, Debby Mangelings and Yvan Vander Heyden\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 53: Determination of absolute configuration using chiroptical methods\u003cbr\u003e \u003ci\u003eJoao Marcos Batista, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 54: Chiral chromatographic methods in the analysis and purification of enantiomers\u003cbr\u003e \u003ci\u003eArnau Novell and Cristina Minguillón\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 55: X-Ray crystallography and 1H NMR anisotropy methods for determination of absolute configurations\u003cbr\u003e \u003ci\u003eNobuyuki Harada\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 56: Crystallization based separation of enantiomers\u003cbr\u003e \u003ci\u003eYaling Wang and Alex Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eChapter 57: Enzymatic dynamic kinetic resolution in stereoselective synthesis\u003cbr\u003e \u003ci\u003eFrancisca Rebolledo, Javier González-Sabín, and Vicente Gotor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSubject index\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52417747452184,"sku":"9781118032176","price":316.79,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781118032176.jpg?v=1784506193","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/stereoselective-synthesis-of-drugs-and-natural-products-2-volume-set-hardback-9781118032176","provider":"Freshly Printed Books","version":"1.0","type":"link"}