{"product_id":"statistical-mechanics-and-stability-of-macromolecules-application-to-bond-disruption-base-pair-separation-melting-and-drug-dissociation-of-the-dna-double-helix-paperback-9780521675574","title":"Statistical Mechanics and Stability of Macromolecules; Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix (Paperback) 9780521675574","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eStatistical Mechanics and Stability of Macromolecules\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eApplication to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eThis book develops a statistical, mechanical analysis of the stability of macromolecules when melting.\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eEarl Prohofsky (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780521675574, Cambridge University Press\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 14 July 2005\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e240 pages, 71 b\/w illus.  25 tables\u003cbr\u003e23.4 x 15.7 x 1.4 cm, 0.35 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThis book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly co-operative transitions needed to explain helix melting. A new theoretical approach for executing macromolecule calculations is developed. In particular, the author devises a method for describing chemical bond disruption in these large systems, which are then used to determine when the helix melts and how drugs can dissociate from the helix. Melting temperatures are found to be in excellent agreement with experimental observations. The book will be of interest to biomolecular dynamics researchers, especially to graduate students in biological physics, theoretical chemistry and molecular biology.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface\u003cbr\u003e 1. Introduction\u003cbr\u003e 2. Macromolecular stability\u003cbr\u003e 3. Lattice dynamics\u003cbr\u003e 4. Effective phonon theory\u003cbr\u003e 5. Premelting disrupted chemical bonds\u003cbr\u003e 6. Co-operative melting\u003cbr\u003e 7. Strained chemical bonds: salt and pressure effects\u003cbr\u003e 8. Bond disruption and conformation change: B to Z confirmation change in DNA\u003cbr\u003e 9. Hydration effects: structural water\u003cbr\u003e 10. Helix with daunomycin intercalated: increased helix stability and daunomycin-DNA bonding constant\u003cbr\u003e 11. Non repeating DNA\u003cbr\u003e 12. Cutting and splicing: junctions, inserts and the replicating fork\u003cbr\u003e 13. Interaction between a helix and a single attached molecule\u003cbr\u003e 14. Energy considerations in bond opening\u003cbr\u003e Appendix 1\u003cbr\u003e Appendix 2\u003cbr\u003e Appendix 3. Index\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Physics [\u003ca title=\"See our other books on Physics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Physics%20%5BPH%5D%22\"\u003ePH\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":46251994546456,"sku":"9780521675574","price":31.89,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780521675574i.jpg?v=1691927964","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/statistical-mechanics-and-stability-of-macromolecules-application-to-bond-disruption-base-pair-separation-melting-and-drug-dissociation-of-the-dna-double-helix-paperback-9780521675574","provider":"Freshly Printed Books","version":"1.0","type":"link"}