{"product_id":"selection-bias-and-covariate-imbalances-in-randomized-clinical-trials-hardback-9780470863626","title":"Selection Bias and Covariate Imbalances in Randomized Clinical Trials (Hardback) 9780470863626","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eSelection Bias and Covariate Imbalances in Randomized Clinical Trials\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eVance Berger (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470863626, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 22 April 2005\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e224 pages\u003cbr\u003e23 x 15.9 x 1.8 cm, 0.454 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"…the author presents a provocative discussion of randomization and TORSB.\" (\u003ci\u003eComputational Statistics\u003c\/i\u003e, January 2008)  \u003cp\u003e\"…recommended to all practitioners and researchers in the field of clinical trials…\" (\u003ci\u003eBiometrics\u003c\/i\u003e, December 2005)\u003c\/p\u003e \u003cp\u003e\" … informative and interesting to read\" \u003ci\u003e(Phamaceutical Statistics Volume 5:2)\u003c\/i\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eSelection bias can, and does, occur, even in randomized clinical trials. Steps need to be taken in order to ensure that this does not compromise the integrity of clinical trials; hence “Selection Bias and Covariate Imbalances in Randomized Clinical Trials” offers a comprehensive treatment of the subject and the methodology involved.  This book:  \u003cul type=\"disc\"\u003e \u003cli\u003eProvides an overview of the hierarchy of study designs, and justifies the position of randomised trials at the top of this hierarchy.\u003c\/li\u003e \u003cli\u003eDiscusses the strengths and defects of randomisation, and provides real evidence to justify concern regarding its defects.\u003c\/li\u003e \u003cli\u003eOutlays the damaging consequences that selection bias causes when it does occur.\u003c\/li\u003e \u003cli\u003eConsiders courses of action that can be taken to manage\/ contain the problem.\u003c\/li\u003e \u003cli\u003ePresents methods that can be used to detect selection bias in randomised trials, and methods to correct for selection bias.\u003c\/li\u003e \u003cli\u003eConcludes by providing a comprehensive plan for managing baseline imbalances and selection bias in randomised trials, and proposing open problems for future research.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e Illustrated with case studies, this book introduces groundbreaking ideas and research that will be invaluable to researchers and practitioners who design and analyse clinical trials. It will also be of interest to graduate students within the field of biostatistics. \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface.  \u003cp\u003e\u003cb\u003ePart I: Is There a Problem with Reliability in Medical Studies?\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 An Evolution of Comparative Methodology.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Single-subject studies.\u003c\/p\u003e \u003cp\u003e1.2 Case series and cohort studies.\u003c\/p\u003e \u003cp\u003e1.3 Historical controls.\u003c\/p\u003e \u003cp\u003e1.4 Parallel control groups.\u003c\/p\u003e \u003cp\u003e1.5 Matched studies.\u003c\/p\u003e \u003cp\u003e1.6 Randomization.\u003c\/p\u003e \u003cp\u003e1.7 Advance randomization.\u003c\/p\u003e \u003cp\u003e1.8 Allocation concealment.\u003c\/p\u003e \u003cp\u003e1.9 Residual selection bias.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Susceptibility of Randomized Trials to Subversion and Selection Bias.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Can randomized trials be subverted?\u003c\/p\u003e \u003cp\u003e2.2 If randomized trials are subverted, do they cease to be randomized trials?\u003c\/p\u003e \u003cp\u003e2.3 What is masking?\u003c\/p\u003e \u003cp\u003e2.4 What is allocation concealment?\u003c\/p\u003e \u003cp\u003e2.5 A double standard.\u003c\/p\u003e \u003cp\u003e2.6 What if allocation concealment could be ensured?\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Evidence of Selection Bias in Randomized Trials.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 The burden of proof regarding the existence of selection bias in randomized trials.\u003c\/p\u003e \u003cp\u003e3.2 Indirect population-level evidence that selection bias exists in randomized trials.\u003c\/p\u003e \u003cp\u003e3.3 Direct trial-level evidence that selection bias exists in randomized trials.\u003c\/p\u003e \u003cp\u003e3.3.1 Heparin for myocardial infarction.\u003c\/p\u003e \u003cp\u003e3.3.2 University Group Diabetes Program.\u003c\/p\u003e \u003cp\u003e3.3.3 Talc and mustine for pleural effusions.\u003c\/p\u003e \u003cp\u003e3.3.4 Tonsillectomy for recurrent throat infection in children.\u003c\/p\u003e \u003cp\u003e3.3.5 Oxytocin and amniotomy for induction of labor.\u003c\/p\u003e \u003cp\u003e3.3.6 Western Washington Intracoronary Streptokinase Trial.\u003c\/p\u003e \u003cp\u003e3.3.7 RSV immune globulin in infants and young children with respiratory syncytial virus.\u003c\/p\u003e \u003cp\u003e3.3.8 A trial to assess episiotomy.\u003c\/p\u003e \u003cp\u003e3.3.9 Canadian National Breast Cancer Screening Study.\u003c\/p\u003e \u003cp\u003e3.3.10 Surgical trial.\u003c\/p\u003e \u003cp\u003e3.3.11 Lifestyle Heart Trial.\u003c\/p\u003e \u003cp\u003e3.3.12 Coronary Artery Surgery Study.\u003c\/p\u003e \u003cp\u003e3.3.13 Etanercept for children with juvenile rheumatoid arthritis.\u003c\/p\u003e \u003cp\u003e3.3.14 Edinburgh Randomized Trial of Breast-Cancer Screening.\u003c\/p\u003e \u003cp\u003e3.3.15 Captopril Prevention Project.\u003c\/p\u003e \u003cp\u003e3.3.16 G¨oteborg (Swedish) Mammography Trial.\u003c\/p\u003e \u003cp\u003e3.3.17 HIP Mammography Trial.\u003c\/p\u003e \u003cp\u003e3.3.18 Hypertension Detection and Follow-Up Program.\u003c\/p\u003e \u003cp\u003e3.3.19 Randomized trial to prevent vertical transmission of HIV-1.\u003c\/p\u003e \u003cp\u003e3.3.20 Effectiveness trial of a diagnostic test.\u003c\/p\u003e \u003cp\u003e3.3.21 South African trial of high-dose chemotherapy for metastatic breast cancer.\u003c\/p\u003e \u003cp\u003e3.3.22 Randomized study of a culturally sensitive AIDS education program.\u003c\/p\u003e \u003cp\u003e3.3.23 Runaway Youth Study.\u003c\/p\u003e \u003cp\u003e3.3.24 Cluster randomized trial of palliative care.\u003c\/p\u003e \u003cp\u003e3.3.25 Randomized trial of methadone with or without heroin.\u003c\/p\u003e \u003cp\u003e3.3.26 Randomized NINDS trial of tissue plasminogen activator for acute ischemic stroke.\u003c\/p\u003e \u003cp\u003e3.3.27 Norwegian Timolol Trial.\u003c\/p\u003e \u003cp\u003e3.3.28 Laparoscopic versus open appendectomy.\u003c\/p\u003e \u003cp\u003e3.3.29 The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) Study.\u003c\/p\u003e \u003cp\u003e3.3.30 The Heart Outcomes Prevention Evaluation (HOPE) Study.\u003c\/p\u003e \u003cp\u003e3.4 In search of better evidence.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Impact of Selection Bias in Randomized Trials.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Quantifying the prediction of future allocations: balanced blocks.\u003c\/p\u003e \u003cp\u003e4.2 Quantifying prediction of future allocations: unbalanced blocks.\u003c\/p\u003e \u003cp\u003e4.3 Quantifying covariate imbalance resulting from selection bias.\u003c\/p\u003e \u003cp\u003e4.4 Quantifying the bias resulting from covariate imbalance.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Actions to be Taken to Improve the Reliability of Medical Studies.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Preventing Selection Bias in Randomized Trials.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Minimizing the Impact of Selection Bias.\u003c\/p\u003e \u003cp\u003e5.2 Biased Selection of Investigators.\u003c\/p\u003e \u003cp\u003e5.3 Minimizing the prediction of future allocations.\u003c\/p\u003e \u003cp\u003e5.3.1 The trade-off between selection bias and chronological bias.\u003c\/p\u003e \u003cp\u003e5.3.2 Notation.\u003c\/p\u003e \u003cp\u003e5.3.3 Varying the block sizes.\u003c\/p\u003e \u003cp\u003e5.3.4 The maximal procedure.\u003c\/p\u003e \u003cp\u003e5.3.5 Extensions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Detecting Selection Bias in Randomized Trials.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Baseline Imbalances in Observed Covariates.\u003c\/p\u003e \u003cp\u003e6.2 Testing for selection bias without baseline analyses.\u003c\/p\u003e \u003cp\u003e6.3 The selection covariate.\u003c\/p\u003e \u003cp\u003e6.4 The role of the reverse propensity score in third-order residual selection bias.\u003c\/p\u003e \u003cp\u003e6.5 Using the reverse propensity score To Test for selection bias: the Berger–Exner test and graph.\u003c\/p\u003e \u003cp\u003e6.6 Using the screening log to test for selection bias.\u003c\/p\u003e \u003cp\u003e6.7 The Ivanova-Barrier-Berger (IBB) Detection Method.\u003c\/p\u003e \u003cp\u003e6.8 Interpreting negative tests of selection bias.\u003c\/p\u003e \u003cp\u003e6.9 When should one test for selection bias?\u003c\/p\u003e \u003cp\u003e6.10 Who should test for selection bias?\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Adjusting for Selection Bias in Randomized Trials.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Methods proposed for addressing non-random baseline imbalances.\u003c\/p\u003e \u003cp\u003e7.2 Selection bias arising from a complete lack of allocation concealment.\u003c\/p\u003e \u003cp\u003e7.3 Selection bias arising from imperfect allocation concealment.\u003c\/p\u003e \u003cp\u003e7.3.1 The RPS approach to adjusting for selection bias.\u003c\/p\u003e \u003cp\u003e7.3.2 The Ivanova–Barrier–Berger (IBB) method for correcting selection bias.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Managing Selection Bias in Randomized Trials.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Action points during the design phase of the trial.\u003c\/p\u003e \u003cp\u003e8.2 Action points during the conduct of the trial.\u003c\/p\u003e \u003cp\u003e8.3 Action points during the analysis of trial data.\u003c\/p\u003e \u003cp\u003e8.4 Action points by party.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eAuthor Index.\u003c\/p\u003e \u003cp\u003eSubject Index.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Mathematics [\u003ca title=\"See our other books on Mathematics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Mathematics%20%5BPB%5D%22\"\u003ePB\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52278056616216,"sku":"9780470863626","price":68.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470863626.jpg?v=1781457761","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/selection-bias-and-covariate-imbalances-in-randomized-clinical-trials-hardback-9780470863626","provider":"Freshly Printed Books","version":"1.0","type":"link"}