{"product_id":"ras-past-present-and-future-hardback-9780128244852","title":"RAS: Past, Present, and Future (Hardback) 9780128244852","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eRAS: Past, Present, and Future\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eA timely review of RAS history, biology, and current strategies to therapeutically inhibit the most frequently mutated oncoprotein in human cancers\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eJohn P. O'Bryan (Volume editor), Gary Piazza (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128244852\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 4 February 2022\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e356 pages\u003cbr\u003e22.9 x 15.2 x 2.5 cm, 0.72 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eAdvances in Cancer Research, volume 153\u003c\/i\u003e provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once “undruggable? RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. A brief history of RAS and the RAS Initiative\u003cbr\u003e\u003ci\u003eFrank McCormick\u003c\/i\u003e\u003cbr\u003e2. Not all RAS mutations are equal: A detailed review of the functional diversity of RAS hot spot mutations\u003cbr\u003e\u003ci\u003eRachel A. Burge and G. Aaron Hobbs\u003c\/i\u003e\u003cbr\u003e3. Drug targeting opportunities en route to Ras nanoclusters\u003cbr\u003e\u003ci\u003eKarolina Pavic, Rohan Chippalkatti, and Daniel Abankwa\u003c\/i\u003e\u003cbr\u003e4. Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer\u003cbr\u003e\u003ci\u003eJ. Nathaniel Diehl, Priya S. Hibshman, Irem Ozkan-Dagliyan, Craig M. Goodwin, Sarah V. Howard, Adrienne D. Cox, and Channing J. Der\u003c\/i\u003e\u003cbr\u003e5. Pan-RAS inhibitors: Hitting multiple RAS isozymes with one stone\u003cbr\u003e\u003ci\u003eAlexander B. Coley, Antonio Ward, Adam B. Keeton, Xi Chen, Yulia Maxuitenko, Aishwarya Prakash, Feng Li, Jeremy B. Foote, Donald J. Buchsbaum, and Gary A. Piazza\u003c\/i\u003e\u003cbr\u003e6. Targeting RAS oncogenesis with SOS1 inhibitors\u003cbr\u003e\u003ci\u003eRoman Christian Hillig and Benjamin Bader\u003c\/i\u003e\u003cbr\u003e7. Inhibition of SHP2 as an approach to block RAS-driven cancers\u003cbr\u003e\u003ci\u003eYu-Ting Chou and Trever G. Bivona\u003c\/i\u003e\u003cbr\u003e8. Targeting the “undruggable? RAS with biologics\u003cbr\u003e\u003ci\u003eMichael Whaby, Imran Khan, and John P. O'Bryan\u003c\/i\u003e\u003cbr\u003e9. Unraveling and targeting RAS-driven metabolic signaling for therapeutic gain\u003cbr\u003e\u003ci\u003eJonathan M. DeLiberty, Ryan Robb, Claire E. Gates, and Kirsten L. Bryant\u003c\/i\u003e\u003cbr\u003e10. The RASopathies: Biology, genetics and therapeutic options\u003cbr\u003e\u003ci\u003eJody Fromm Longo and Steven L. Carroll\u003c\/i\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Virology [\u003ca title=\"See our other books on Virology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Virology%20%5Bnon-medical%5D%20%5BPSGL%5D%22\"\u003enon-medical PSGL\u003c\/a\u003e], Cellular biology [\u003ca title=\"See our other books on Cellular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cellular%20biology%20%5Bcytology%5D%20%5BPSF%5D%22\"\u003ecytology PSF\u003c\/a\u003e], Genetics [\u003ca title=\"See our other books on Genetics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Genetics%20%5Bnon-medical%5D%20%5BPSAK%5D%22\"\u003enon-medical PSAK\u003c\/a\u003e], Immunology [\u003ca title=\"See our other books on Immunology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Immunology%20%5BMJCM%5D%22\"\u003eMJCM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46650407846168,"sku":"9780128244852","price":109.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128244852.jpg?v=1694108368","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/ras-past-present-and-future-hardback-9780128244852","provider":"Freshly Printed Books","version":"1.0","type":"link"}