{"product_id":"quantitative-applications-of-mass-spectrometry-paperback-softback-9780470025161","title":"Quantitative Applications of Mass Spectrometry (Paperback \/ softback) 9780470025161","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eQuantitative Applications of Mass Spectrometry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003ePietro Traldi (Author), Franco Magno (Author), Irma Lavagnini (Author), Roberta Seraglia (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470025161, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 7 April 2006\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e160 pages\u003cbr\u003e22.4 x 15.2 x 1 cm, 0.249 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"…anyone needing to do serious quantitative work using GC\/MS could learn from these authors.\" (\u003ci\u003eCHOICE\u003c\/i\u003e, January 2007)\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThis text presents the information needed to design a successful quantitative analysis using mass spectrometric techniques currently available and widely employed. It is devoted to the researchers of different areas, who use mass spectrometry as a detector suitable for the measurements of their interest.  \u003cul\u003e \u003cli\u003eAn essential book for the practicing mass spectroscopist\u003c\/li\u003e \u003cli\u003eA genuine 'how-to' text for the practitioner focusing on quantification rather than instrumental design and techniques\u003c\/li\u003e \u003cli\u003eUp-to-date structured text describing methods, experimental strategy, capabilities and limitations, with data analysis and interpretation\u003c\/li\u003e \u003cli\u003eBrings together material widely dispersed in the pertinent literature into one unique source\u003c\/li\u003e \u003cli\u003eInternationally recognized group of authors\u003c\/li\u003e \u003c\/ul\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eAcknowledgements xi\u003c\/p\u003e \u003cp\u003eIntroduction xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 What Instrumental Approaches are Available 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Ion Sources 1\u003c\/p\u003e \u003cp\u003e1.1.1 Electron Ionization 3\u003c\/p\u003e \u003cp\u003e1.1.2 Chemical Ionization 4\u003c\/p\u003e \u003cp\u003e1.1.3 Atmospheric Pressure Chemical Ionization 6\u003c\/p\u003e \u003cp\u003e1.1.4 Electrospray Ionization 8\u003c\/p\u003e \u003cp\u003e1.1.5 Atmospheric Pressure Photoionization 11\u003c\/p\u003e \u003cp\u003e1.1.6 Matrix-assisted Laser Desorption\/Ionization 12\u003c\/p\u003e \u003cp\u003e1.2 Mass Analysers 14\u003c\/p\u003e \u003cp\u003e1.2.1 Mass Resolution 14\u003c\/p\u003e \u003cp\u003e1.2.2 Sector Analysers 15\u003c\/p\u003e \u003cp\u003e1.2.3 Quadrupole Analysers 19\u003c\/p\u003e \u003cp\u003e1.2.4 Time-of-flight 25\u003c\/p\u003e \u003cp\u003e1.3 GC\/MS 27\u003c\/p\u003e \u003cp\u003e1.3.1 Total Ion Current (TIC) Chromatogram 27\u003c\/p\u003e \u003cp\u003e1.3.2 Reconstructed Ion Chromatogram (RIC) 28\u003c\/p\u003e \u003cp\u003e1.3.3 Multiple Ion Detection (MID) 29\u003c\/p\u003e \u003cp\u003e1.4 LC\/MS 29\u003c\/p\u003e \u003cp\u003e1.5 MS\/MS 30\u003c\/p\u003e \u003cp\u003e1.5.1 MS\/MS by Double Focusing Instruments 30\u003c\/p\u003e \u003cp\u003e1.5.2 MS\/MS by Triple Quadrupoles 31\u003c\/p\u003e \u003cp\u003e1.5.3 MS\/MS by Ion Traps 32\u003c\/p\u003e \u003cp\u003e1.5.4 MS\/MS by Q-TOF 34\u003c\/p\u003e \u003cp\u003eReferences 34\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 How to Design a Quantitative Analysis 37\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 General Strategy 38\u003c\/p\u003e \u003cp\u003e2.1.1 Project 41\u003c\/p\u003e \u003cp\u003e2.1.2 Sampling 41\u003c\/p\u003e \u003cp\u003e2.1.3 Sample Treatment 42\u003c\/p\u003e \u003cp\u003e2.1.4 Instrumental Analysis 43\u003c\/p\u003e \u003cp\u003e2.1.5 Method Validation 53\u003c\/p\u003e \u003cp\u003eReferences 53\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 How to Improve Specificity 55\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Choice of a Suitable Chromatographic Procedure 56\u003c\/p\u003e \u003cp\u003e3.1.1 GC\/MS Measurements in Low and High Resolution Conditions 56\u003c\/p\u003e \u003cp\u003e3.1.2 LC\/ESI\/MS and LC\/APCI\/MS Measurements 61\u003c\/p\u003e \u003cp\u003e3.2 Choice of a Suitable Ionization Method 79\u003c\/p\u003e \u003cp\u003e3.3 An Example of High Specificity and Selectivity Methods: The Dioxin Analysis 85\u003c\/p\u003e \u003cp\u003e3.3.1 Use of High Resolution MID Analysis 85\u003c\/p\u003e \u003cp\u003e3.3.2 NICI in the Analysis of Dioxins, Furans and PCBs 93\u003c\/p\u003e \u003cp\u003e3.3.3 MS\/MS in the Detection of Dioxins, Furans and PCBs 95\u003c\/p\u003e \u003cp\u003e3.4 An Example of MALDI\/MS in Quantitative Analysis of Polypeptides: Substance P 101\u003c\/p\u003e \u003cp\u003eReferences 106\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Some Thoughts on Calibration and Data Analysis 107\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Calibration Designs 108\u003c\/p\u003e \u003cp\u003e4.2 Homoscedastic and Heteroscedastic Data 108\u003c\/p\u003e \u003cp\u003e4.2.1 Variance Model 109\u003c\/p\u003e \u003cp\u003e4.3 Calibration Models 109\u003c\/p\u003e \u003cp\u003e4.3.1 Unweighted Regression 109\u003c\/p\u003e \u003cp\u003e4.3.2 Weighted Regression 119\u003c\/p\u003e \u003cp\u003e4.3.3 A Practical Example 126\u003c\/p\u003e \u003cp\u003e4.4 Different Approaches to Estimate Detection and Quantification Limits 130\u003c\/p\u003e \u003cp\u003eReferences 132\u003c\/p\u003e \u003cp\u003eIndex 135\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand 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