{"product_id":"proteomic-and-metabolomic-approaches-to-biomarker-discovery-paperback-9780128186077","title":"Proteomic and Metabolomic Approaches to Biomarker Discovery (Paperback) 9780128186077","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProteomic and Metabolomic Approaches to Biomarker Discovery\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003eThoroughly covers the proteomic and metabolomic methods and technologies used for biomarker discovery and validation, from study design to execution\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eHaleem J. Issaq (Edited by), Timothy D. Veenstra (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128186077, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 29 October 2019\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e504 pages\u003cbr\u003e23.4 x 19 x 3.1 cm, 1 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eProteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition\u003c\/i\u003e covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process.\u003c\/p\u003e  \u003cp\u003eThis second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. Biomarker discovery: Study design and execution\u003cbr\u003e2. Proteomic and mass spectrometry technologies for biomarker discovery\u003cbr\u003e3. Tissue sample preparation for proteomic analysis\u003cbr\u003e4. Sample preparation in global metabolomics of biological fluids and tissues\u003cbr\u003e5. Serum and plasma collection: Preanalytical variables and standard operating procedures in biomarker research\u003cbr\u003e6. Sample depletion, fractionation, and enrichment for biomarker discovery\u003cbr\u003e7. Current NMR strategies for biomarker\u003cbr\u003e8. Gas chromatography\/mass spectrometrybased metabonomics\u003cbr\u003e9. Liquid chromatographic methods combined with mass spectrometry in metabolomics\u003cbr\u003e10. Capillary electrophoresis-mass spectrometry for proteomic and metabolic\u003cbr\u003e11. Associating 2-DE and CPLLs for low-abundance protein discovery: A winning strategy\u003cbr\u003e12. Two-dimensional difference in gel electrophoresis for biomarker discovery \u003cbr\u003e13. Affinity-targeting schemes for protein biomarkers\u003cbr\u003e14. Protein and metabolite identification\u003cbr\u003e15. Quantitative proteomics in development of disease protein biomarkers\u003cbr\u003e16. Mass spectrometry and NMR spectroscopy based quantitative metabolomics\u003cbr\u003e17. Top-down mass spectrometry for protein molecular diagnostics, structure analysis, and biomarker discovery\u003cbr\u003e18. Using data-independent mass spectrometry to extend detectable dynamic range without prior fractionation\u003cbr\u003e19. Imaging mass spectrometry of intact biomolecules in tissue section\u003cbr\u003e20. Mass spectrometry-based approach for protein biomarker verification\u003cbr\u003e21. Mass spectrometry metabolomic data handling for biomarker discovery\u003cbr\u003e22. Analytical methods and biomarker validation\u003cbr\u003e23. Multivariate analysis for metabolomics and proteomics data\u003cbr\u003e24. Cell surface protein enrichment for biomarker and drug target discovery using mass spectrometry-based proteomic\u003cbr\u003e25. Advances in lipidomics for cancer biomarker discovery\u003cbr\u003e26. Mass spectrometry for the identification of protein biomarkers in urinary extracellular vesicles\u003cbr\u003e27. Designing clinical studies for biomarker discovery: The DESIGN criteria\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biochemistry [\u003ca title=\"See our other books on Biochemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemistry%20%5BPSB%5D%22\"\u003ePSB\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649064259864,"sku":"9780128186077","price":117.79,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128186077.jpg?v=1694096935","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/proteomic-and-metabolomic-approaches-to-biomarker-discovery-paperback-9780128186077","provider":"Freshly Printed Books","version":"1.0","type":"link"}