{"product_id":"protein-kinase-ck2-hardback-9780470963036","title":"Protein Kinase CK2 (Hardback) 9780470963036","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProtein Kinase CK2\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eLorenzo A. Pinna (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470963036, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 14 December 2012\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e480 pages\u003cbr\u003e25.2 x 17.8 x 2.5 cm, 1.016 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eProtein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. \u003ci\u003eProtein Kinase CK2\u003c\/i\u003e comprehensively brings together the varied work being done on this critical enzyme.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eProtein Kinase CK2\u003c\/i\u003e is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent.\u003c\/p\u003e \u003cp\u003eWith contributions from the world’s leading experts in the field, \u003ci\u003eProtein Kinase CK2\u003c\/i\u003e will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eEditor\u003c\/b\u003e\u003cbr\u003e \u003cb\u003eLorenzo A. Pinna\u003c\/b\u003e is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAlso Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology:\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePlant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology\u003c\/i\u003e\u003cbr\u003e Edited by Cesar G. Fraga\u003cbr\u003e ISBN: 978-0-470-28721-7\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Molecular and Structural Aspects 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Structural Bases of Protein Kinase CK2 Function and Inhibition 3\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eKarsten Niefind and Roberto Battistutta\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 3\u003c\/p\u003e \u003cp\u003eBasic Structure\/Function Relationships of CK2 8\u003c\/p\u003e \u003cp\u003eCK2 Inhibitors 37\u003c\/p\u003e \u003cp\u003eConclusions and Outlook 60\u003c\/p\u003e \u003cp\u003eAcknowledgments 61\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 The Interactome of Protein Kinase CK2 76\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMathias Montenarh and Claudia Götz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 76\u003c\/p\u003e \u003cp\u003eFrom the Outside to the Inside: Interaction of CK2 with Membrane Proteins 78\u003c\/p\u003e \u003cp\u003eRegulating Gene Expression: Interaction of CK2 with Components of Signaling Cascades, Transcription Factors and DNA Modifying Enzymes 82\u003c\/p\u003e \u003cp\u003eMastering Nucleic Acid Functions: Interaction of CK2 with Proteins of the Replication, Transcription, and Translation Machinery of the Cell 87\u003c\/p\u003e \u003cp\u003eLet It Roll: Interaction of CK2 with Cell Cycle Regulatory Proteins 90\u003c\/p\u003e \u003cp\u003eGuardian Angels: Interaction of CK2 with Proteins That Maintain the Cellular Integrity 93\u003c\/p\u003e \u003cp\u003eLive and Let Die: Interaction of CK2 with Proteins of the Apoptotic Pathway 96\u003c\/p\u003e \u003cp\u003eHighways in the Cell: Interaction of CK2 with the Cytoskeleton and Motor Proteins 96\u003c\/p\u003e \u003cp\u003eCollaborating with the Enemy: Interaction of CK2 with Proteins Implicated in Viral Infections 98\u003c\/p\u003e \u003cp\u003eLast But Not Least: Miscellaneous 99\u003c\/p\u003e \u003cp\u003eConcluding Remarks 101\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 CK2 Contribution to the Generation of the Human Phosphoproteome 117\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLuca Cesaro and Mauro Salvi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eKinases Contribution to the Human Phosphoproteome 117\u003c\/p\u003e \u003cp\u003eCK2 Substrate Specificity 118\u003c\/p\u003e \u003cp\u003eSubphosphoproteomes of Proteins with Specific Functions 122\u003c\/p\u003e \u003cp\u003eSubphosphoproteomes of Cellular Compartments 123\u003c\/p\u003e \u003cp\u003eAbsolute Quantification of Yeast Phosphoproteome Reflects the Constitutive Activity of CK2 125\u003c\/p\u003e \u003cp\u003eConclusions 125\u003c\/p\u003e \u003cp\u003eAcknowledgments 126\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Functional Aspects 129\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 CK2 in Embryonic Development 131\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLaura Macias Alvarez, Jesus Revuelta-Cervantes, and Isabel Dominguez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCK2 in Yeast Biology 131\u003c\/p\u003e \u003cp\u003eCK2 in Invertebrate Development 135\u003c\/p\u003e \u003cp\u003eCK2 in Vertebrate Development 139\u003c\/p\u003e \u003cp\u003eCK2 in Plant Development 148\u003c\/p\u003e \u003cp\u003eCK2 in Animal Developmental Signaling Pathways 149\u003c\/p\u003e \u003cp\u003eDiscussion 155\u003c\/p\u003e \u003cp\u003eOutlook 157\u003c\/p\u003e \u003cp\u003eAcknowledgments 158\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Protein Kinase CK2: At the Crossroads of Pathways Controlling Cell Proliferation and Survival 169\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMichelle Gabriel and David W. Litchfield\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eGeneral Introduction 169\u003c\/p\u003e \u003cp\u003eProtein Kinase CK2 170\u003c\/p\u003e \u003cp\u003eCK2 in Cancer 171\u003c\/p\u003e \u003cp\u003eInvolvement of CK2 in Signaling Pathways Controlling Proliferation and Death 172\u003c\/p\u003e \u003cp\u003eConcluding Remarks 182\u003c\/p\u003e \u003cp\u003eAcknowledgments 183\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 The Role of Protein Kinase CK2 in the p53 Response 190\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDavid W. Meek\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eProtein Kinase CK2 190\u003c\/p\u003e \u003cp\u003eThe p53 Network 191\u003c\/p\u003e \u003cp\u003eThe Interaction Between p53 and CK2 192\u003c\/p\u003e \u003cp\u003eRegulation of p53 by Phosphorylation of Ser392 193\u003c\/p\u003e \u003cp\u003eProposed Mechanism for Regulation of p53 Phosphorylation at Ser392 (the “CK2” Site) 194\u003c\/p\u003e \u003cp\u003ePhosphorylation of p53 by CK2 in a Physiological Context? 196\u003c\/p\u003e \u003cp\u003eA Broader Role for CK2 in Regulating the p53 Network? 197\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 The Pivotal Role of CK2 in the Kinome-Targeting Hsp90 Chaperone Machinery 205\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eYoshihiko Miyata\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eProtein Kinase CK2 205\u003c\/p\u003e \u003cp\u003eHsp90: A Major Molecular Chaperone 206\u003c\/p\u003e \u003cp\u003eCo-Chaperones That Regulate Hsp90 Function 208\u003c\/p\u003e \u003cp\u003eHsp90 and Signaling Protein Kinases 212\u003c\/p\u003e \u003cp\u003ePhosphorylation and the Regulation of Hsp90 by CK2 217\u003c\/p\u003e \u003cp\u003ePhosphorylation of Cdc37 by CK2 218\u003c\/p\u003e \u003cp\u003eA Crucial Role of CK2-Dependent Phosphorylation in the Functional Regulation of Cdc37 220\u003c\/p\u003e \u003cp\u003eRegulation of the Cdc37 Phosphorylation Cycle 220\u003c\/p\u003e \u003cp\u003eRegulatory Phosphorylation of FKBP52 by CK2 223\u003c\/p\u003e \u003cp\u003ePhosphorylation of p23 by CK2 224\u003c\/p\u003e \u003cp\u003eTargeting the CK2-Cdc37-Hsp90 Trinity for Cancer Chemotherapy 224\u003c\/p\u003e \u003cp\u003eConclusion 227\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 CK2: A Global Regulator of Cell Survival 239\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eBarbara Guerra and Olaf-Georg Issinger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCK2 and Cell Survival: Strategies, Methods, and Techniques for Exploring Its Role 239\u003c\/p\u003e \u003cp\u003eCK2 and Cellular Death 244\u003c\/p\u003e \u003cp\u003eRole of CK2 in DNA Damage 246\u003c\/p\u003e \u003cp\u003eRole of the Individual CK2 Subunits in Cell Survival 248\u003c\/p\u003e \u003cp\u003eCK2 Status in Non-neoplastic Cells 250\u003c\/p\u003e \u003cp\u003eCK2 Activity and Expression in Neoplasia 252\u003c\/p\u003e \u003cp\u003eCK2 in Heterotransplanted Tumors in Nude Mice 252\u003c\/p\u003e \u003cp\u003eCK2 Holoenzyme and Its Subunits 253\u003c\/p\u003e \u003cp\u003eTumor Hypoxia 255\u003c\/p\u003e \u003cp\u003eConclusion 257\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Specific Features of Plant CK2 267\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMarta Riera, Isabel Cristina Vélez-Bermúdez, Tommaso Legnaioli, and Montserrat Pagès\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 267\u003c\/p\u003e \u003cp\u003eCK2α Catalytic Subunits 268\u003c\/p\u003e \u003cp\u003eCK2β Regulatory Subunits 274\u003c\/p\u003e \u003cp\u003eCK2 Holoenzyme 276\u003c\/p\u003e \u003cp\u003ePhysiological Role of CK2 in Plants 279\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Ck2 And Neoplasia 291\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 The Oncogenic Potential of CK2 293\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDavid C. Seldin and Esther Landesman-Bollag\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 293\u003c\/p\u003e \u003cp\u003eCK2 Overexpression in Human Cancer 294\u003c\/p\u003e \u003cp\u003eCK2 Is Overexpressed in Animal Models of Cancer 297\u003c\/p\u003e \u003cp\u003eCK2 Overexpression in Transgenic Mice Leads to Cancer 297\u003c\/p\u003e \u003cp\u003ePossible Targets of CK2 in Cancer: Wnt, NF-κB, and PI3-Kinase Pathways 298\u003c\/p\u003e \u003cp\u003eConclusions 301\u003c\/p\u003e \u003cp\u003eAcknowledgments 301\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Addiction of Cancer Cells to CK2: Survival at All Costs or Achilles’ Heel? 305\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMaria Ruzzene\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eMany Substrates, One Major Role 305\u003c\/p\u003e \u003cp\u003eA Lateral Player 308\u003c\/p\u003e \u003cp\u003e“More Necessary” for Some Cells 310\u003c\/p\u003e \u003cp\u003eTo Survive at All Costs 310\u003c\/p\u003e \u003cp\u003eA Novel Achilles’ Heel of Cancer Cells 311\u003c\/p\u003e \u003cp\u003eThe Right Weapons 312\u003c\/p\u003e \u003cp\u003eAcknowledgments 313\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 CK2 Suppression of Apoptosis and Its Implication in Cancer Biology and Therapy 319\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJaneen H. Trembley, JingJiang Wu, Gretchen M. Unger, Betsy T. Kren, and Khalil Ahmed\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 319\u003c\/p\u003e \u003cp\u003eCK2 Dynamics in Cell Growth and Cell Death 320\u003c\/p\u003e \u003cp\u003eCK2 and Hallmarks of Cancer 323\u003c\/p\u003e \u003cp\u003eCK2 as Target of Cancer Therapy 329\u003c\/p\u003e \u003cp\u003eAcknowledgments 333\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Protein Kinase CK2 in Normal and Malignant Hematopoiesis 344\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eFrancesco Piazza\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eHematopoiesis and Blood Tumors: General Concepts 344\u003c\/p\u003e \u003cp\u003eCK2 Role in Mouse Embryonic Development: Insights into CK2 Involvement in Blood Development 345\u003c\/p\u003e \u003cp\u003eCK2-Directed Regulation of Hematopoiesis-Associated Molecules and Signal Transduction Pathways 346\u003c\/p\u003e \u003cp\u003eRole of CK2 in Hematologic Malignancies 351\u003c\/p\u003e \u003cp\u003eCK2 in Blood Tumors Arising from Lymphocytes 352\u003c\/p\u003e \u003cp\u003eCK2 in Blood Tumors Arising from Myeloid Cells 353\u003c\/p\u003e \u003cp\u003eConclusions 355\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Role of CK2 in the Control of Cell Plasticity in Breast Carcinoma Progression 363\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eOdile Filhol, Alexandre Deshiere, and Claude Cochet\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 363\u003c\/p\u003e \u003cp\u003eDysregulation of CK2 in Mammary Tumorigenesis 364\u003c\/p\u003e \u003cp\u003eCK2 as a Guardian of Epithelial Cell Integrity 364\u003c\/p\u003e \u003cp\u003eUnbalanced Expression of CK2 Subunits Is Correlated with Hypoxia and EMT-Related Markers 366\u003c\/p\u003e \u003cp\u003eCK2β Subunit Silencing Induces EMT-Like Morphological Changes 367\u003c\/p\u003e \u003cp\u003eGene Expression Profiling 373\u003c\/p\u003e \u003cp\u003eCK2β Silencing Triggers Snail1 Induction 373\u003c\/p\u003e \u003cp\u003eOverexpression of SIX1 in CK2β-Depleted Cells 374\u003c\/p\u003e \u003cp\u003eConclusions 375\u003c\/p\u003e \u003cp\u003eAcknowledgments 377\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 CK2 as a Logical Target in Cancer Therapy: Potential for Combining CK2 Inhibitors with Various Classes of Cancer Therapeutic Agents 383\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDenis Drygin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 384\u003c\/p\u003e \u003cp\u003eSuppression of Apoptosis 385\u003c\/p\u003e \u003cp\u003ePI3K-Akt-mTOR Signaling 390\u003c\/p\u003e \u003cp\u003ePromotion of Angiogenesis 393\u003c\/p\u003e \u003cp\u003eHsp90 Machinery 395\u003c\/p\u003e \u003cp\u003eNF-κB Transcription 399\u003c\/p\u003e \u003cp\u003eWnt Signaling 402\u003c\/p\u003e \u003cp\u003eEpithelial-Mesynchemal Transition 405\u003c\/p\u003e \u003cp\u003eDNA Damage Repair 405\u003c\/p\u003e \u003cp\u003eOther Pathways 409\u003c\/p\u003e \u003cp\u003eConcluding Remarks 411\u003c\/p\u003e \u003cp\u003eAcknowledgments 411\u003c\/p\u003e \u003cp\u003eAppendix: Ck2 And Its False Sisters: The Recent Solution Of A Very “Cold Case” 440\u003c\/p\u003e \u003cp\u003eIndex 442\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biology, life sciences [\u003ca title=\"See our other books on Biology, life sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biology,%20life%20sciences%20%5BPS%5D%22\"\u003ePS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Brand New","offer_id":52278162325784,"sku":"9780470963036","price":138.29,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470963036.jpg?v=1781458722","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/protein-kinase-ck2-hardback-9780470963036","provider":"Freshly Printed Books","version":"1.0","type":"link"}