{"product_id":"protein-folding-in-silico-protein-folding-versus-protein-structure-prediction-hardback-9781907568176","title":"Protein Folding in Silico; Protein Folding Versus Protein Structure Prediction (Hardback) 9781907568176","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProtein Folding in Silico\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eProtein Folding Versus Protein Structure Prediction\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eIrena Roterman-Konieczna (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781907568176, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 4 October 2012\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e240 pages\u003cbr\u003e23.4 x 15.6 x 2.1 cm, 0.5 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eProtein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The opening chapters discuss the early stage intermediate and late stage intermediate models, followed by a discussion of structural information that affects the interpretation of the folding process. The second half of the book covers a variety of topics including ligand binding site recognition, the \"fuzzy oil drop\" model and its use in simulation of the polypeptide chain, and misfolded proteins. The book ends with an overview of a number of other ab initio methods for protein structure predictions and some concluding remarks.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eDedication\u003c\/p\u003e \u003cp\u003eList of figures\u003c\/p\u003e \u003cp\u003eList of tables\u003c\/p\u003e \u003cp\u003eAbout the editor\u003c\/p\u003e \u003cp\u003eList of contributors\u003c\/p\u003e \u003cp\u003eIntroduction\u003c\/p\u003e \u003cp\u003eChapter 1: The early-stage intermediate\u003c\/p\u003e \u003cp\u003eAbstract\u003c\/p\u003e \u003cp\u003e1.1 Geometric model\u003c\/p\u003e \u003cp\u003e1.2 Structural alphabet\u003c\/p\u003e \u003cp\u003e1.3 Contingency table\u003c\/p\u003e \u003cp\u003e1.4 In search of structural similarities\u003c\/p\u003e \u003cp\u003eChapter 2: The late-stage intermediate\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e2.1 The “ fuzzy oil drop ? model\u003c\/p\u003e \u003cp\u003e2.2 Quantitative description of the hydrophobic core\u003c\/p\u003e \u003cp\u003e2.3 Protein characteristics with respect to the hydrophobic core\u003c\/p\u003e \u003cp\u003e2.4 Simulation of late-stage folding\u003c\/p\u003e \u003cp\u003eChapter 3: Structural information involved in the interpretation of the stepwise protein folding process\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e3.1 Balancing the quantity of information in the amino acid sequence and the early-stage intermediate\u003c\/p\u003e \u003cp\u003e3.2 Zones on the Ramachandran map\u003c\/p\u003e \u003cp\u003eChapter 4: The divergence entropy characterizing the internal force field in proteins\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e4.1 Internal force field for nonbonding interactions\u003c\/p\u003e \u003cp\u003e4.2 The impact of ligands\u003c\/p\u003e \u003cp\u003e4.3 Structures of homodimers – protein-protein interaction\u003c\/p\u003e \u003cp\u003e4.4 Protein containing a catalytic center\u003c\/p\u003e \u003cp\u003e4.5 The role of exons\u003c\/p\u003e \u003cp\u003e4.6 Conclusions\u003c\/p\u003e \u003cp\u003eChapter 5: Ligand-binding-site recognition\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e5.1 General model\u003c\/p\u003e \u003cp\u003e5.2 ROC curves\u003c\/p\u003e \u003cp\u003e5.3 Summary\u003c\/p\u003e \u003cp\u003eChapter 6: Use of the “fuzzy oil drop” model to identify the complexation area in protein homodimers\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e6.1 General description\u003c\/p\u003e \u003cp\u003e6.2 ROC curves\u003c\/p\u003e \u003cp\u003e6.3 Conclusions\u003c\/p\u003e \u003cp\u003eChapter 7: Simulation of the polypeptide chain folding process using the \"fuzzy oil drop\" model\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e7.1 Simulation of the folding process in the presence of an external hydrophobic force field\u003c\/p\u003e \u003cp\u003e7.2 Folding in the presence of a ligand\u003c\/p\u003e \u003cp\u003e7.3 Influence of external factors on polypeptide chain folding\u003c\/p\u003e \u003cp\u003eChapter 8: Misfolded proteins\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e8.1 Introduction\u003c\/p\u003e \u003cp\u003e8.2 In silico experiment\u003c\/p\u003e \u003cp\u003e8.3 Conclusions\u003c\/p\u003e \u003cp\u003e8.4 Appendix 1: details of the molecular dynamics simulation\u003c\/p\u003e \u003cp\u003e8.5 Appendix 2: details of the cluster analysis\u003c\/p\u003e \u003cp\u003eChapter 9: A Short description of other selected ab initio methods for protein structure prediction\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e9.1 Introduction\u003c\/p\u003e \u003cp\u003e9.2 Simplifying the geometric model and the field function\u003c\/p\u003e \u003cp\u003e9.3 Lattice model\u003c\/p\u003e \u003cp\u003e9.4 ROSETTA\u003c\/p\u003e \u003cp\u003e9.5 In search of a global minimum – force field deformation\u003c\/p\u003e \u003cp\u003eChapter 10: Conclusion\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e10.1 Acknowledgements\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biochemistry [\u003ca title=\"See our other books on Biochemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemistry%20%5BPSB%5D%22\"\u003ePSB\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Woodhead Publishing","offers":[{"title":"Default Title","offer_id":46651786494232,"sku":"9781907568176","price":112.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9781907568176_81dfad0c-07d3-422d-95d3-098e3f76ba47.jpg?v=1695018011","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/protein-folding-in-silico-protein-folding-versus-protein-structure-prediction-hardback-9781907568176","provider":"Freshly Printed Books","version":"1.0","type":"link"}