{"product_id":"protein-chaperones-and-protection-from-neurodegenerative-diseases-hardback-9780470569078","title":"Protein Chaperones and Protection from Neurodegenerative Diseases (Hardback) 9780470569078","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProtein Chaperones and Protection from Neurodegenerative Diseases\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eStephan N. Witt (Edited by), SN Witt (Author), Vladimir Uversky (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470569078, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 19 August 2011\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e448 pages\u003cbr\u003e24.1 x 16.1 x 2.8 cm, 0.794 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eHow protein chaperones protect cells from neurodegenerative diseases\u003c\/p\u003e \u003cp\u003eIncluding contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases.\u003c\/p\u003e \u003cp\u003eExamining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperone properties. The intersection of molecular chaperones and neurodegeneration is an intensely studied area, partly because of the potential for manipulating the expression of molecular chaperones to thwart the progression of debilitating diseases, and partly because of the ever-aging global population.\u003c\/p\u003e \u003cp\u003eDiscussing the potential to harness the power of protein chaperones, and future directions for research, discovery, and therapeutics, this book is essential reading for scientists working in the fields of biochemistry, molecular medicine, pharmacology and drug discovery, biotechnology and pharmaceutical companies, advanced students, and anyone interested in this cutting-edge topic.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cb\u003ePreface.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eIntroduction.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eContributors.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Intrinsically Disordered Chaperones and Neurodegeneration (\u003c\/b\u003e\u003ci\u003eVladimir N. Uversky).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Redox Regulation of Protein Misfolding, Synaptic Damage, and Neuronal Loss in Neurodegenerative Diseases (\u003c\/b\u003e\u003ci\u003eTomohiro Nakamura and Stuart A. Lipton).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Chaperone-Mediated Autophagy and Parkinson’s Disease (\u003c\/b\u003e\u003ci\u003eMarta Martinez-Vicente and Ester Wong).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Chaperone and Anti-Chaperone Properties of Synuclein: Implications for Development, Aging, and Neurodegenerative Disease (\u003c\/b\u003e\u003ci\u003eMakoto Hashimoto, Kazuanri Sekiyama, Akio Sekigawa, and Masayo Fujita).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The Ubiquitin–Proteasome System in Neurodegenerative Diseases: More than the Usual Suspects (\u003c\/b\u003e\u003ci\u003eAnne Bertolotti).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Regulation of the Polyglutamine Androgen Receptor by the Hsp90\/Hsp70-Based Chaperone Machinery (\u003c\/b\u003e\u003ci\u003eAndrew P. Lieberman and William B. Pratt).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Amyloid Remodeling by Hsp104 (\u003c\/b\u003e\u003ci\u003eJames Shorter).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Chaperone-Dependent Amyloid Assembly and Prion Toxicity (\u003c\/b\u003e\u003ci\u003eDaniel W. Summers, Katie J. Wolfe, and Douglas M. Cyr).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Modulation of Amyloid Propagation in Yeast by Hsp70 and its Regulators and Chaperone Partners (\u003c\/b\u003e\u003ci\u003eDaniel C. Masison).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 ALS and the Copper Chaperone CCS (\u003c\/b\u003e\u003ci\u003eMarjatta Son and Jeffrey L. Elliott).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Emerging Area: TorsinA, a Novel ATP-Dependent Factor Linked to Dystonia (\u003c\/b\u003e\u003ci\u003eMichal Zolkiewski and Hui-Chuan Wu).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Therapeutics: Harnessing the Power of Molecular and Pharmacological Chaperones (\u003c\/b\u003e\u003ci\u003eDavid S. Gross, Ronald L. Klein and Stephan N. Witt).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276364607768,"sku":"9780470569078","price":115.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470569078.jpg?v=1781367457","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/protein-chaperones-and-protection-from-neurodegenerative-diseases-hardback-9780470569078","provider":"Freshly Printed Books","version":"1.0","type":"link"}