{"product_id":"progress-in-medicinal-chemistry-hardback-9780444530189","title":"Progress in Medicinal Chemistry (Hardback) 9780444530189","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProgress in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eA highly valuable reference for medicinal chemists, biologists, doctors, and pharmacists\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eG. Lawton (Series edited by), David R. Witty (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444530189, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 8 April 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e420 pages\u003cbr\u003e27.9 x 21 x 2.7 cm, 0.67 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eAppropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging:  * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications)\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e* HIV integrase (discovery of the first-in-class inhibitor drug raltegravir) \u003cbr\u003e* 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation) \u003cbr\u003e* Nicotinic a7 choline receptor (agonists and positive allosteric modulators)\u003cbr\u003e* Bradykinin receptor (new approach to pain therapy) \u003cbr\u003e* Histone deacetylase (new drugs for cancer) \u003cbr\u003e* 5-HT2c receptor modulators (various CNS indications)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":46651492073752,"sku":"9780444530189","price":118.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444530189_1f03e331-7a8b-43aa-bc44-67d82645228c.jpg?v=1694987179","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/progress-in-medicinal-chemistry-hardback-9780444530189","provider":"Freshly Printed Books","version":"1.0","type":"link"}