{"product_id":"probabilistic-boolean-networks-the-modeling-and-control-of-gene-regulatory-networks-the-modeling-and-control-of-gene-regulatory-networks-paperback-softback-9780898716924","title":"Probabilistic Boolean Networks – The Modeling and Control of Gene Regulatory Networks; The Modeling and Control of Gene Regulatory Networks (Paperback \/ softback) 9780898716924","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProbabilistic Boolean Networks – The Modeling and Control of Gene Regulatory Networks\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eThe Modeling and Control of Gene Regulatory Networks\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eThe first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eIlya Shmulevich (Author), Edward R. Dougherty (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780898716924\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 30 December 2009\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e280 pages\u003cbr\u003e24.8 x 17.7 x 1.5 cm, 0.506 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe first comprehensive treatment of probabilistic Boolean networks (an important model class for studying genetic regulatory networks), this book covers basic model properties, including the relationships between network structure and dynamics, steady-state analysis, and relationships to other model classes. As the PBN model can serve as a mathematical framework for studying the basic issues of systems-based genomics, the book builds a rigorous mathematical foundation for exploring these issues, which include long-run dynamical properties and how these correspond to therapeutic goals; the effect of complexity on model inference and the resulting consequences of model uncertainty; altering network dynamics via structural intervention, such as perturbing gene logic; optimal control of regulatory networks over time; limitations imposed on the ability to achieve optimal control owing to model complexity; and the effects of asynchronicity. The authors unify different strands of current research and address emerging issues such as constrained control, greedy control, and asynchronicity.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface\u003cbr\u003e 1. Boolean networks\u003cbr\u003e 2. Structure and dynamics of probabilistic Boolean networks\u003cbr\u003e 3. Inference of model structure\u003cbr\u003e 4. Structural intervention\u003cbr\u003e 5. External control\u003cbr\u003e 6. Asynchronous networks\u003cbr\u003e Bibliography\u003cbr\u003e Index.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Miscellaneous items [\u003ca title=\"See our other books on Miscellaneous items\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Miscellaneous%20items%20%5BWZ%5D%22\"\u003eWZ\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"MP–SIA SIAM – Society for Industrial and Applied M","offers":[{"title":"Brand New","offer_id":52410747879704,"sku":"9780898716924","price":47.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780898716924i.jpg?v=1784251381","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/probabilistic-boolean-networks-the-modeling-and-control-of-gene-regulatory-networks-the-modeling-and-control-of-gene-regulatory-networks-paperback-softback-9780898716924","provider":"Freshly Printed Books","version":"1.0","type":"link"}