{"product_id":"preparation-of-compounds-labeled-with-tritium-and-carbon-14-hardback-9780470516072","title":"Preparation of Compounds Labeled with Tritium and Carbon-14 (Hardback) 9780470516072","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003ePreparation of Compounds Labeled with Tritium and Carbon-14\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eRolf Voges (Author), J. Richard Heys (Author), Thomas Moenius (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470516072, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 20 March 2009\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e688 pages\u003cbr\u003e25.2 x 17.4 x 4.3 cm, 1.279 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eCompounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals.  \u003cp\u003e\u003ci\u003ePreparation of Compounds Labeled with Tritium and Carbon-14\u003c\/i\u003e is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures.  Topics include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e Formulation of synthetic strategies for preparing labeled compounds\u003c\/li\u003e \u003cli\u003eIsotope exchange methods and synthetic alternatives for preparing tritiated compounds\u003c\/li\u003e \u003cli\u003eIn-depth discussion of carbon-14 building blocks and their utility in synthesis\u003c\/li\u003e \u003cli\u003ePreparation of enantiomerically pure isotopically labeled compounds\u003c\/li\u003e \u003cli\u003eApplications of biotransformations\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003ePreparation of Compounds Labeled with Tritium and Carbon-14\u003c\/i\u003e is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface.  \u003cp\u003e\u003cb\u003eGlossary.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAuthor Biographies.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Physical Properties of Tritium and Carbon-14.\u003c\/p\u003e \u003cp\u003e1.2 Purification.\u003c\/p\u003e \u003cp\u003e1.3 Analysis.\u003c\/p\u003e \u003cp\u003e1.4 Stability and Storage of Compounds Labeled with Tritium or Carbon-14.\u003c\/p\u003e \u003cp\u003e1.5 Specialist Techniques and Equipment.\u003c\/p\u003e \u003cp\u003eReferences .\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Strategies for Target Preparation.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Formulating Target Specifications.\u003c\/p\u003e \u003cp\u003e2.2 Planning Radiotracer Preparations.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Preparation of Tritium-Labeled Compounds by Isotope Exchange Reactions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Homogeneous Acid- or Base-Catalyzed Exchange.\u003c\/p\u003e \u003cp\u003e3.2 Heterogeneous Catalysis with Tritium in Solvent.\u003c\/p\u003e \u003cp\u003e3.3 Heterogeneous Catalysis in Solution with Tritium Gas.\u003c\/p\u003e \u003cp\u003e3.4 Homogeneous Catalysis in Solution with Tritiated Water.\u003c\/p\u003e \u003cp\u003e3.5 Homogeneous Catalysis with Tritium Gas.\u003c\/p\u003e \u003cp\u003e3.6 Solvent-Free Catalytic Exchange.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Preparation of Tritium-Labeled Compounds by Chemical Synthesis.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Catalytic Tritiations.\u003c\/p\u003e \u003cp\u003e4.2 Catalytic Tritiolyses.\u003c\/p\u003e \u003cp\u003e4.3 Tritide Reductions.\u003c\/p\u003e \u003cp\u003e4.4 Small Tritiated Building Blocks.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Barium [\u003csup\u003e14\u003c\/sup\u003eC]Carbonate and the Preparation of Carbon-14-Labeled Compounds via One-Carbon Building Blocks of the [\u003csup\u003e14\u003c\/sup\u003eC]Carbon Dioxide Tree.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 [\u003csup\u003e14\u003c\/sup\u003eC]Carbon Dioxide (\u003csup\u003e14\u003c\/sup\u003eCO\u003csub\u003e2\u003c\/sub\u003e).\u003c\/p\u003e \u003cp\u003e5.2 [\u003csup\u003e14\u003c\/sup\u003eC]Carbon Monoxide (\u003csup\u003e14\u003c\/sup\u003eCO).\u003c\/p\u003e \u003cp\u003e5.3 [\u003csup\u003e14\u003c\/sup\u003eC]Formic Acid (H\u003csup\u003e14\u003c\/sup\u003eCOOH).\u003c\/p\u003e \u003cp\u003e5.4 [\u003csup\u003e14\u003c\/sup\u003eC]Formaldehyde (H\u003csup\u003e14\u003c\/sup\u003eCHO).\u003c\/p\u003e \u003cp\u003e5.5 [\u003csup\u003e14\u003c\/sup\u003eC]Methyl Iodide (\u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e3\u003c\/sub\u003eI).\u003c\/p\u003e \u003cp\u003e5.6 [\u003csup\u003e14\u003c\/sup\u003eC]Nitromethane (\u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e3\u003c\/sub\u003eNO\u003csub\u003e2\u003c\/sub\u003e).\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Preparation of Carbon-14-Labeled Compounds via Multi-Carbon Building Blocks of the [\u003csup\u003e14\u003c\/sup\u003eC]Carbon Dioxide Tree.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 [\u003csup\u003e14\u003c\/sup\u003eC]Acetic Acid and Its Derivatives.\u003c\/p\u003e \u003cp\u003e6.2 Halo[\u003csup\u003e14\u003c\/sup\u003eC]acetates.\u003c\/p\u003e \u003cp\u003e6.3 [\u003csup\u003e14\u003c\/sup\u003eC]Acetone.\u003c\/p\u003e \u003cp\u003e6.4 Alkyl [\u003csup\u003e14\u003c\/sup\u003eC]Acetoacetate.\u003c\/p\u003e \u003cp\u003e6.5 [\u003csup\u003e14\u003c\/sup\u003eC]Malonates.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Preparation of Carbon-14-Labeled Compounds via the [\u003csup\u003e14\u003c\/sup\u003eC]Cyanide Tree.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Metal [\u003csup\u003e14\u003c\/sup\u003eC]Cyanides.\u003c\/p\u003e \u003cp\u003e7.2 Preparation of Other Building Blocks from [\u003csup\u003e14\u003c\/sup\u003eC]Cyanide.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Preparation of Carbon-14-Labeled Compounds via the [\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Acetylene Tree.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 [\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Acetylene (H\u003csup\u003e14\u003c\/sup\u003eC≡\u003csup\u003e14\u003c\/sup\u003eCH).\u003c\/p\u003e \u003cp\u003e8.2 [\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Acetaldehyde (\u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e3\u003c\/sub\u003e \u003csup\u003e14\u003c\/sup\u003eCHO).\u003c\/p\u003e \u003cp\u003e8.3 [1,2-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Acetic Acid (\u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e3\u003c\/sub\u003e \u003csup\u003e14\u003c\/sup\u003eCOOH).\u003c\/p\u003e \u003cp\u003e8.4 2-[2,3-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Propyne-1-ol ([2,3-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Propargyl Alcohol) and 2-[2,3-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Butyne-1,4-diol.\u003c\/p\u003e \u003cp\u003e8.5 Methyl [2,3-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Propiolate (H\u003csup\u003e14\u003c\/sup\u003eC≡\u003csup\u003e14\u003c\/sup\u003eCCOOMe) and Dimethyl [2,3-\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Acetylenedicarboxylate (HOOC\u003csup\u003e14\u003c\/sup\u003eC_\u003csup\u003e14\u003c\/sup\u003eCCOOH).\u003c\/p\u003e \u003cp\u003e8.6 1,2-[\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Dibromoethane (Br\u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e2\u003c\/sub\u003e \u003csup\u003e14\u003c\/sup\u003eCH\u003csub\u003e2\u003c\/sub\u003eBr).\u003c\/p\u003e \u003cp\u003e8.7 [\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003e2\u003c\/sub\u003e]Ethylene Oxide.\u003c\/p\u003e \u003cp\u003e8.8 [\u003csup\u003e14\u003c\/sup\u003eC\u003csub\u003en\u003c\/sub\u003e]Benzene and the Synthesis of Ring-Labeled Aromatic Compounds.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Preparation of Carbon-14-Labeled Compounds via the [\u003csup\u003e14\u003c\/sup\u003eC]Cyanamide Tree.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 [\u003csup\u003e14\u003c\/sup\u003eC]Cyanamide (H\u003csub\u003e2\u003c\/sub\u003eN\u003csup\u003e14\u003c\/sup\u003eC≡N).\u003c\/p\u003e \u003cp\u003e9.2 [\u003csup\u003e14\u003c\/sup\u003eC]Guanidine (H\u003csub\u003e2\u003c\/sub\u003eN\u003csup\u003e14\u003c\/sup\u003eC=NH)NH\u003csub\u003e2\u003c\/sub\u003e).\u003c\/p\u003e \u003cp\u003e9.3 [14C]Urea, H2N14CONH2.\u003c\/p\u003e \u003cp\u003e9.4 [\u003csup\u003e14\u003c\/sup\u003eC]Thiourea, H\u003csub\u003e2\u003c\/sub\u003eN\u003csup\u003e14\u003c\/sup\u003eCSNH\u003csub\u003e2\u003c\/sub\u003e .\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Reconstitution Strategies.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Replacement Strategies.\u003c\/p\u003e \u003cp\u003e10.2 Disconnection?Reconnection Strategies.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Preparation of Enantiomerically Pure Compounds Labeled with Isotopes of Hydrogen and Carbon.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Resolution of Racemates.\u003c\/p\u003e \u003cp\u003e11.2 Enantioselective Synthetic Methods.\u003c\/p\u003e \u003cp\u003e11.3 Diastereoselective Synthetic Procedures.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Biotransformations in the Preparation of Compounds Labeled with Carbon and Hydrogen Isotopes.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Applications of Isolated Enzymes.\u003c\/p\u003e \u003cp\u003e12.2 Application of Cell-Containing Systems.\u003c\/p\u003e \u003cp\u003e12.3 Biocatalyzed Synthesis of Key Intermediates for Reconstitution Approaches.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52475167080728,"sku":"9780470516072","price":122.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470516072.jpg?v=1785805871","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/preparation-of-compounds-labeled-with-tritium-and-carbon-14-hardback-9780470516072","provider":"Freshly Printed Books","version":"1.0","type":"link"}