{"product_id":"polymer-protein-conjugates-from-pegylation-and-beyond-paperback-9780444640819","title":"Polymer-Protein Conjugates; From Pegylation and Beyond (Paperback \/ softback) 9780444640819","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003ePolymer-Protein Conjugates\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eFrom Pegylation and Beyond\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eFocuses on recent trends in the development of polymer–protein conjugates, clinical results from approved conjugates, and future directions\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eGianfranco Pasut (Edited by), Samuel Zalipsky (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444640819\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 31 October 2019\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e512 pages\u003cbr\u003e23.4 x 19 x 3.2 cm, 1.06 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003ePolymer–Protein Conjugates: From Pegylation and Beyond \u003c\/i\u003ehelps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. \u003c\/p\u003e  \u003cp\u003eAfter five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eIntroduction and General Aspects of the Technology\u003c\/b\u003e 1. Evolution of Polymer Conjugation to proteins 2. PEGylated Proteins: A Rational Design for Mitigating Clearance Mechanisms and Altering Biodistribution 3. Overcoming barriers for tumor-targeted drug delivery: the power of macromolecular anticancer drugs with the EPR effect and the modulation of vascular physiology\u003c\/p\u003e \u003cp\u003e\u003cb\u003eToxicity and Immunogenicity Studies and Clinical Stage Conjugate Products \u003c\/b\u003e4. PEG-protein conjugates: Non-clinical and clinical toxicity considerations 5. Immunological responses to PEGylated proteins: anti-PEG antibodies 6. Immunogenicity assessment of PEGylated proteins, Lonquex, a PEGylated G-CSF case study 7. PEG-Protein conjugates: regulatory requirements for characterization 8. PEGylation of human coagulation factor VIII and other plasma proteins 9. Pegvorhyaluronidase Alfa: A PEGylated Recombinant Human Hyaluronidase PH20 for the Treatment of Cancers That Accumulate Hyaluronan 10. Challenges in the analytical characterization of PEGylated asparaginases\u003c\/p\u003e \u003cp\u003e\u003cb\u003eNovel Site-Selective Methods of Conjugation \u003c\/b\u003e11. Glycan-targeted PEGylation for selective modification of proteins 12. Sialyltransferase mediated glycoPEGylation 13. Enzymatic approaches to new protein conjugates 14. Site-specific Polymer-protein conjugates by Cys mutation 15. Site-specific PEGylation of interferon beta-1b: from bench to clinic 16. Protein modification by bis-alkylation\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAlternative non-PEG polymers and architectures\u003c\/b\u003e 17. In vivo properties of therapeutic bioconjugates composed of proteins and architecturally\/functionally complex polymers 18. Poly(2-oxazoline)-protein conjugates 19. Polysaccharides for protein and peptide conjugation 20. Polysialylation of human coagulation factor VIII\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biochemical engineering [\u003ca title=\"See our other books on Biochemical engineering\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemical%20engineering%20%5BTC%5D%22\"\u003eTC\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46651519435032,"sku":"9780444640819","price":133.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444640819_0d3b734c-17a6-44a5-ab45-e1554d0513ff.jpg?v=1694987368","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/polymer-protein-conjugates-from-pegylation-and-beyond-paperback-9780444640819","provider":"Freshly Printed Books","version":"1.0","type":"link"}