{"product_id":"phosphodiesterase-inhibitors-hardback-9780122107207","title":"Phosphodiesterase Inhibitors (Hardback) 9780122107207","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003ePhosphodiesterase Inhibitors\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eClive Page (Series edited by), Christian Schudt (Volume editor), Gordon Dent (Volume editor), Klaus F. Rabe (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780122107207, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 16 August 1996\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e228 pages\u003cbr\u003e24.8 x 19 x 2 cm, 0.69 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eNon-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eK.M. Ferguson and K. Loughney\u003c\/i\u003e, Identification and Quantification of PDE Isoenzymes and Subtypes by Molecular Biological Methods.\u003cbr\u003e\u003ci\u003eH. Tenor and C. Schudt\u003c\/i\u003e, Analysis of PDE Isoenzyme Profiles in Cells and Tissues by Pharmacological Methods.\u003cbr\u003e\u003ci\u003eK.F. Rabe\u003c\/i\u003e, Effects of Theophylline and Nonselective Xanthine Derivatives on PDE Isoenzymes and Cellular Function.\u003cbr\u003e\u003ci\u003eR.K. Sharma\u003c\/i\u003e, Interaction of PDE I Inhibitors with Isoenzymes and Cell Functions.\u003cbr\u003e\u003ci\u003eR. Fischmeister\u003c\/i\u003e, EHNA as an Inhibitor of PDE II.\u003cbr\u003e\u003ci\u003eV.C. Manganiello\u003c\/i\u003e, PDE II Inhibitors as Therapeutic Agents.\u003cbr\u003e\u003ci\u003eM.A. Giembycz\u003c\/i\u003e, Interaction of PDE IV Inhibitors with Enzymes and Cell Functions and their Therapeutic Potential.\u003cbr\u003e\u003ci\u003eP.J. Silver\u003c\/i\u003e, Inhibition of PDE Isoenzymes and Cell Function by Selective PDE V Inhibitors.\u003cbr\u003e\u003ci\u003eJ.D. Corbin\u003c\/i\u003e, Design and Synthesis of Xanthines and Cyclic GMP Analogues as Potent Inhibitors of PDE V and PDE I.\u003cbr\u003e\u003ci\u003eA. Hatzelmann\u003c\/i\u003e, Enzymatic and Functional Inhibition of Dual-Selective Inhibitors.\u003cbr\u003e\u003ci\u003eR. Alvarez\u003c\/i\u003e, Subtype Selectivity, Inhibition of Cell Function and Therapeutic Potential of RS 25344.\u003cbr\u003e\u003ci\u003eJ.E. Souness\u003c\/i\u003e, Characterization of Different States of PDE IV by Rolipram and RP 73401.\u003cbr\u003e\u003ci\u003eT.J. Torphy\u003c\/i\u003e, Functional Significance of Two Sites for Inhibitors at PDE IV.\u003cbr\u003eSubject Index.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Cellular biology [\u003ca title=\"See our other books on Cellular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cellular%20biology%20%5Bcytology%5D%20%5BPSF%5D%22\"\u003ecytology PSF\u003c\/a\u003e], Molecular biology [\u003ca title=\"See our other books on Molecular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Molecular%20biology%20%5BPSD%5D%22\"\u003ePSD\u003c\/a\u003e], Biochemical immunology [\u003ca title=\"See our other books on Biochemical immunology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemical%20immunology%20%5BPSBM%5D%22\"\u003ePSBM\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649195528472,"sku":"9780122107207","price":91.79,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780122107207.jpg?v=1694098542","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/phosphodiesterase-inhibitors-hardback-9780122107207","provider":"Freshly Printed Books","version":"1.0","type":"link"}