{"product_id":"pharmaceutical-biotechnology-concepts-and-applications-hardback-9780470012444","title":"Pharmaceutical Biotechnology; Concepts and Applications (Hardback) 9780470012444","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003ePharmaceutical Biotechnology\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eConcepts and Applications\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eGary Walsh (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470012444, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 6 July 2007\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e498 pages\u003cbr\u003e24.9 x 19.6 x 3.6 cm, 1.066 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003ePharmaceutical Biotechnology\u003c\/i\u003e offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, initial chapters offer a broad introduction to protein science and recombinant DNA technology- key areas that underpin the whole subject. Subsequent chapters focus upon the development, production and analysis of these substances. Finally the book moves on to explore the science, biotechnology and medical applications of specific biotech products categories. These include not only protein-based substances but also nucleic acid and cell-based products.  \u003cul\u003e \u003cli\u003eintroduces essential principles underlining modern biotechnology- recombinant DNA technology and protein science\u003c\/li\u003e \u003cli\u003ean invaluable introduction to this fast-moving subject aimed specifically at pharmacy and medical students\u003c\/li\u003e \u003cli\u003eincludes specific ‘product category chapters’ focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products.\u003c\/li\u003e \u003cli\u003eentire chapter devoted to the principles of genetic engineering and how these drugs are developed.\u003c\/li\u003e \u003cli\u003eincludes numerous relevant case studies to enhance student understanding\u003c\/li\u003e \u003cli\u003eno prior knowledge of protein structure is assumed \u003c\/li\u003e \u003c\/ul\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cb\u003ePreface.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eAcronyms.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Pharmaceuticals, biologics and biopharmaceuticals.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction to pharmaceutical products.\u003c\/p\u003e \u003cp\u003e1.2 Biopharmaceuticals and pharmaceutical biotechnology.\u003c\/p\u003e \u003cp\u003e1.3 History of the pharmaceutical industry.\u003c\/p\u003e \u003cp\u003e1.4 The age of biopharmaceuticals.\u003c\/p\u003e \u003cp\u003e1.5 Biopharmaceuticals: current status and future prospects.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Protein structure.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction.\u003c\/p\u003e \u003cp\u003e2.2 Overview of protein structure.\u003c\/p\u003e \u003cp\u003e2.3 Higher level structure.\u003c\/p\u003e \u003cp\u003e2.4 Protein stability and folding.\u003c\/p\u003e \u003cp\u003e2.5 Protein post-translational modifi cation.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Gene manipulation and recombinant DNA technology.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction.\u003c\/p\u003e \u003cp\u003e3.2 Nucleic acids: function and structure.\u003c\/p\u003e \u003cp\u003e3.3 Recombinant production of therapeutic proteins.\u003c\/p\u003e \u003cp\u003e3.4 Classical gene cloning and identifi cation.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The drug development process.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction.\u003c\/p\u003e \u003cp\u003e4.2 Discovery of biopharmaceuticals.\u003c\/p\u003e \u003cp\u003e4.3 The impact of genomics and related technologies upon drug discovery.\u003c\/p\u003e \u003cp\u003e4.4 Gene chips.\u003c\/p\u003e \u003cp\u003e4.5 Proteomics.\u003c\/p\u003e \u003cp\u003e4.6 Structural genomics.\u003c\/p\u003e \u003cp\u003e4.7 Pharmacogenetics.\u003c\/p\u003e \u003cp\u003e4.8 Initial product characterization.\u003c\/p\u003e \u003cp\u003e4.9 Patenting.\u003c\/p\u003e \u003cp\u003e4.10 Delivery of biopharmaceuticals.\u003c\/p\u003e \u003cp\u003e4.10.3 Nasal, transmucosal and transdermal delivery systems.\u003c\/p\u003e \u003cp\u003e4.11 Preclinical studies.\u003c\/p\u003e \u003cp\u003e4.12 Pharmacokinetics and pharmacodynamics.\u003c\/p\u003e \u003cp\u003e4.13 Toxicity studies.\u003c\/p\u003e \u003cp\u003e4.14 The role and remit of regulatory authorities.\u003c\/p\u003e \u003cp\u003e4.15 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Sources and upstream processing.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction.\u003c\/p\u003e \u003cp\u003e5.2 Sources of biopharmaceuticals.\u003c\/p\u003e \u003cp\u003e5.3 Upstream processing.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Downstream processing.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction.\u003c\/p\u003e \u003cp\u003e6.2 Initial product recovery.\u003c\/p\u003e \u003cp\u003e6.3 Cell disruption.\u003c\/p\u003e \u003cp\u003e6.4 Removal of nucleic acid.\u003c\/p\u003e \u003cp\u003e6.5 Initial product concentration.\u003c\/p\u003e \u003cp\u003e6.6 Chromatographic purifi cation.\u003c\/p\u003e \u003cp\u003e6.7 High-performance liquid chromatography of proteins.\u003c\/p\u003e \u003cp\u003e6.8 Purifi cation of recombinant proteins.\u003c\/p\u003e \u003cp\u003e6.9 Final product formulation.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Product analysis.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction.\u003c\/p\u003e \u003cp\u003e7.2 Protein-based contaminants.\u003c\/p\u003e \u003cp\u003e7.3 Removal of altered forms of the protein of interest from the product stream.\u003c\/p\u003e \u003cp\u003e7.4 Detection of protein-based product impurities.\u003c\/p\u003e \u003cp\u003e7.5 Immunological approaches to detection of contaminants.\u003c\/p\u003e \u003cp\u003e7.6 Endotoxin and other pyrogenic contaminants.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 The cytokines: The interferon family.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Cytokines.\u003c\/p\u003e \u003cp\u003e8.1.1 Cytokine receptors.\u003c\/p\u003e \u003cp\u003e8.1.2 Cytokines as biopharmaceuticals.\u003c\/p\u003e \u003cp\u003e8.2 The interferons.\u003c\/p\u003e \u003cp\u003e8.3 Interferon biotechnology.\u003cbr\u003e \u003cbr\u003e 8.4 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Cytokines: Interleukins and tumour necrosis factor.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction.\u003c\/p\u003e \u003cp\u003e9.2 Interleukin-2.\u003c\/p\u003e \u003cp\u003e9.3 Interleukin-1.\u003c\/p\u003e \u003cp\u003e9.4 Interleukin-11.\u003c\/p\u003e \u003cp\u003e9.5 Tumour necrosis factors.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Growth factors.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction.\u003c\/p\u003e \u003cp\u003e10.2 Haematopoietic growth factors.\u003c\/p\u003e \u003cp\u003e10.3 Growth factors and wound healing.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Therapeutic hormones.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction.\u003c\/p\u003e \u003cp\u003e11.2 Insulin.\u003c\/p\u003e \u003cp\u003e11.3 Glucagon.\u003c\/p\u003e \u003cp\u003e11.4 Human growth hormone.\u003c\/p\u003e \u003cp\u003e11.5 The gonadotrophins.\u003c\/p\u003e \u003cp\u003e11.6 Medical and veterinary applications of gonadotrophins.\u003c\/p\u003e \u003cp\u003e11.7 Additional recombinant hormones now approved.\u003c\/p\u003e \u003cp\u003e11.8 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Recombinant blood products and therapeutic enzymes.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction.\u003c\/p\u003e \u003cp\u003e12.2 Haemostasis.\u003c\/p\u003e \u003cp\u003e12.3 Anticoagulants.\u003c\/p\u003e \u003cp\u003e12.4 Thrombolytic agents.\u003c\/p\u003e \u003cp\u003e12.5 Enzymes of therapeutic value.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Antibodies, vaccines and adjuvants.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction.\u003c\/p\u003e \u003cp\u003e13.2 Traditional polyclonal antibody preparations.\u003c\/p\u003e \u003cp\u003e13.3 Monoclonal antibodies.\u003c\/p\u003e \u003cp\u003e13.4 Vaccine technology.\u003c\/p\u003e \u003cp\u003e13.5 Adjuvant technology.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Nucleic-acid- and cell-based therapeutics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction.\u003c\/p\u003e \u003cp\u003e14.2 Gene therapy.\u003c\/p\u003e \u003cp\u003e14.3 Vectors used in gene therapy.\u003c\/p\u003e \u003cp\u003e14.4 Gene therapy and genetic disease.\u003c\/p\u003e \u003cp\u003e14.5 Gene therapy and cancer.\u003c\/p\u003e \u003cp\u003e14.6 Gene therapy and AIDS.\u003c\/p\u003e \u003cp\u003e14.7 Antisense technology.\u003c\/p\u003e \u003cp\u003e14.8 Oligonucleotide pharmacokinetics and delivery.\u003c\/p\u003e \u003cp\u003e14.9 Aptamers.\u003c\/p\u003e \u003cp\u003e14.10 Cell- and tissue-based therapies.\u003c\/p\u003e \u003cp\u003e14.11 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biology, life sciences [\u003ca title=\"See our other books on Biology, life sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biology,%20life%20sciences%20%5BPS%5D%22\"\u003ePS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52255224561944,"sku":"9780470012444","price":143.39,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470012444.jpg?v=1781273801","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/pharmaceutical-biotechnology-concepts-and-applications-hardback-9780470012444","provider":"Freshly Printed Books","version":"1.0","type":"link"}