{"product_id":"pancreatic-cancer-basic-mechanisms-and-therapies-hardback-9780443133541","title":"Pancreatic Cancer: Basic Mechanisms and Therapies (Hardback) 9780443133541","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003ePancreatic Cancer: Basic Mechanisms and Therapies\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThis thematic volume provides a picture and roadmap of what we now know and where we hope to be in the future relative to diagnosing and treating pancreatic cancer\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eLuni Emdad (Volume editor), Azeddine Atfi (Volume editor), Rajan Gogna (Volume editor), Jose G Trevino (Volume editor), Paul B. Fisher (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780443133541, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 1 June 2023\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e390 pages\u003cbr\u003e22.9 x 15.2 x 2.3 cm, 0.45 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePancreatic Cancer: Basic Mechanisms and Therapies, Volume 159 in the Advances in Cancer Research, presents the latest release in this ongoing, well-regarded serial with invaluable information on the exciting and fast-moving field of cancer research.\u003c\/p\u003e  \u003cp\u003ePancreatic cancer (PC) is the third leading cause of cancer-related deaths in the United States. Greater than 90% PCs are Pancreatic ductal adenocarcinomas (PDAC) which have a dismal estimated 5-year overall survival of only 11%. PDAC is predicted to become the second leading cause of mortality in the United States by 2030. In the clinic, the PDAC patients often present with incurable disease at the time of first diagnosis. This cancer is particularly lethal because of its propensity to spread quickly to distant organs including the lymphatic system. PDAC metastasis occurs shortly after tumor initiation and is caused by a complex interaction between autonomous tumor cells and cellular elements of the tumor microenvironment. Although PDAC remains a challenging disease to treat and a leading cause of cancer-related deaths, progress is being made in disease etiology and pathogenesis, and intensive research is focused on developing optimal treatment approaches for patients. Considering the continuous progress being made in understanding PDAC pathogenesis and designing new therapies, it was considered timely to develop an up-to-date thematic issue of Advances in Cancer Research (ACR) focused on PDAC. \u003c\/p\u003e  \u003cp\u003eIn this thematic issue, we have included ten review articles by experts that cover cancer disparities, PDAC pathobiology, the roles of the tumor microenvironment, tumor heterogeneity, PC stem cells, genetic and signaling events critical for PDAC pathogenesis, Immunotherapy and chemoresistance in PDAC, and different PDAC mouse models. This special issue highlights recent research progress in PDAC, which bridges the gap between basic and clinical research.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. Notch signaling pathway in pancreatic tumorigenesis\u003cbr\u003eKeli Xu\u003cbr\u003e2. EMT in Pancreatic Ductal Adenocarcinoma\u003cbr\u003eAzeddine Atfi\u003cbr\u003e3. Review of Immunocompetent In-vivo Models of PDAC  OR Stromal Microenvironment Impact on Pacreatic Cancer Progression and Metastasis\u003cbr\u003eVignesh Vudatha and Jose Trevino\u003cbr\u003e4. Interplay between MAP Kinases and tumor microenvironment: Opportunity for immunotherapy in pancreatic cancer\u003cbr\u003eAjay Rana and Kumar Sandeep\u003cbr\u003e5. KRAS in pancreatic cancer: Emerging therapeutic strategies\u003cbr\u003eDaohong Zhou\u003cbr\u003e6. Disparities in Pancreatic Cancer Clinical Trials\u003cbr\u003eAllison Neal Martin and Rebecca A. Snyder\u003cbr\u003e7. Tumor heterogeneity: an oncogenic driver of PDAC progression and therapy resistance under stress conditions\u003cbr\u003eEsha Madan\u003cbr\u003e8. Oncogenic Signaling Pathways in Pancreatic Ductal Adenocarcinoma\u003cbr\u003eKedar Nath Natarajan\u003cbr\u003e9. Chemoresistance in Pancreatic Ductal Adenocarcinoma: Overcoming Resistance to Therapy\u003cbr\u003ePraveen Bhoopathi\u003cbr\u003e10. Tumor microenvironment interactions with cancer stem cells in pancreatic ductal adenocarcinoma\u003cbr\u003eRajan Gogna\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Virology [\u003ca title=\"See our other books on Virology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Virology%20%5Bnon-medical%5D%20%5BPSGL%5D%22\"\u003enon-medical PSGL\u003c\/a\u003e], Cellular biology [\u003ca title=\"See our other books on Cellular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cellular%20biology%20%5Bcytology%5D%20%5BPSF%5D%22\"\u003ecytology PSF\u003c\/a\u003e], Genetics [\u003ca title=\"See our other books on Genetics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Genetics%20%5Bnon-medical%5D%20%5BPSAK%5D%22\"\u003enon-medical PSAK\u003c\/a\u003e], Immunology [\u003ca title=\"See our other books on Immunology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Immunology%20%5BMJCM%5D%22\"\u003eMJCM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46651403174168,"sku":"9780443133541","price":113.75,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780443133541.jpg?v=1694979774","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/pancreatic-cancer-basic-mechanisms-and-therapies-hardback-9780443133541","provider":"Freshly Printed Books","version":"1.0","type":"link"}