{"product_id":"organic-synthesis-the-disconnection-approach-hardback-9780470712375","title":"Organic Synthesis; The Disconnection Approach (Hardback) 9780470712375","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eOrganic Synthesis\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eThe Disconnection Approach\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eStuart Warren (Author), Paul Wyatt (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470712375, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 21 November 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e352 pages\u003cbr\u003e25.4 x 19.6 x 2.5 cm, 0.822 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e?The authors have succeeded admirably in the updating of a classic in the pedagogy of organic chemistry.? ( \u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e , August 2009)  \u003cp\u003e?This book is suitable for advanced undergraduate students, researchers and professional chemists. Both the writing and the diagrams are simple and clear.? ( \u003ci\u003eReviews\u003c\/i\u003e, May 2009)\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eOne approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. \u003cp\u003e\u003ci\u003e\u003cb\u003eOrganic Synthesis: The Disconnection Approach, 2nd Edition\u003c\/b\u003e\u003c\/i\u003e introduces this important technique, to help students to design their own organic syntheses. There are forty chapters: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems.\u003c\/p\u003e \u003cp\u003eExamples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given.\u003c\/p\u003e \u003cp\u003eThis second edition has been fully revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, “Organic Synthesis: Strategy and Control”.\u003c\/p\u003e \u003cp\u003eSeveral chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eOrganic Synthesis: The Disconnection Approach, 2nd edition\u003c\/i\u003e provides a full course in retrosynthetic analysis for chemistry and biochemistry students and a refresher for organic chemists working in industry and academia.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eGeneral References xi\u003c\/p\u003e \u003cp\u003e1. The Disconnection Approach 1\u003c\/p\u003e \u003cp\u003e2. Basic Principles: Synthons and Reagents Synthesis of Aromatic Compounds 7\u003c\/p\u003e \u003cp\u003e3. Strategy I: The Order of Events 17\u003c\/p\u003e \u003cp\u003e4. One-Group C–X Disconnections 23\u003c\/p\u003e \u003cp\u003e5. Strategy II: Chemoselectivity 29\u003c\/p\u003e \u003cp\u003e6. Two-Group C–X Disconnections 35\u003c\/p\u003e \u003cp\u003e7. Strategy III: Reversal of Polarity, Cyclisations, Summary of Strategy 45\u003c\/p\u003e \u003cp\u003e8. Amine Synthesis 53\u003c\/p\u003e \u003cp\u003e9. Strategy IV: Protecting Groups 61\u003c\/p\u003e \u003cp\u003e10. One Group C–C Disconnections I: Alcohols 69\u003c\/p\u003e \u003cp\u003e11. General Strategy A: Choosing a Disconnection 77\u003c\/p\u003e \u003cp\u003e12. Strategy V: Stereoselectivity A 83\u003c\/p\u003e \u003cp\u003e13. One Group C–C Disconnections II: Carbonyl Compounds 93\u003c\/p\u003e \u003cp\u003e14. Strategy VI: Regioselectivity 101\u003c\/p\u003e \u003cp\u003e15. Alkene Synthesis 107\u003c\/p\u003e \u003cp\u003e16. Strategy VII: Use of Acetylenes (Alkynes) 115\u003c\/p\u003e \u003cp\u003e17. Two-Group C–C Disconnections I: Diels-Alder Reactions 121\u003c\/p\u003e \u003cp\u003e18. Strategy VIII: Introduction to Carbonyl Condensations 129\u003c\/p\u003e \u003cp\u003e19. Two-Group C–C Disconnections II: 1,3-Difunctionalised Compounds 133\u003c\/p\u003e \u003cp\u003e20. Strategy IX: Control in Carbonyl Condensations 139\u003c\/p\u003e \u003cp\u003e21. Two-Group C–C Disconnections III: 1,5-Difunctionalised Compounds Conjugate (Michael) Addition and Robinson Annelation 151\u003c\/p\u003e \u003cp\u003e22. Strategy X: Aliphatic Nitro Compounds in Synthesis 161\u003c\/p\u003e \u003cp\u003e23. Two-Group Disconnections IV: 1,2-Difunctionalised Compounds 167\u003c\/p\u003e \u003cp\u003e24. Strategy XI: Radical Reactions in Synthesis 177\u003c\/p\u003e \u003cp\u003e25. Two-Group Disconnections V: 1,4-Difunctionalised Compounds 185\u003c\/p\u003e \u003cp\u003e26. Strategy XII: Reconnection 193\u003c\/p\u003e \u003cp\u003e27. Two-Group C–C Disconnections VI: 1,6-diCarbonyl Compounds 199\u003c\/p\u003e \u003cp\u003e28. General Strategy B: Strategy of Carbonyl Disconnections 207\u003c\/p\u003e \u003cp\u003e29. Strategy XIII: Introduction to Ring Synthesis: Saturated Heterocycles 217\u003c\/p\u003e \u003cp\u003e30. Three-Membered Rings 229\u003c\/p\u003e \u003cp\u003e31. Strategy XIV: Rearrangements in Synthesis 237\u003c\/p\u003e \u003cp\u003e32. Four-Membered Rings: Photochemistry in Synthesis 245\u003c\/p\u003e \u003cp\u003e33. Strategy XV: The Use of Ketenes in Synthesis 251\u003c\/p\u003e \u003cp\u003e34. Five-Membered Rings 255\u003c\/p\u003e \u003cp\u003e35. Strategy XVI: Pericyclic Reactions in Synthesis: Special Methods for Five-Membered Rings 261\u003c\/p\u003e \u003cp\u003e36. Six-Membered Rings 269\u003c\/p\u003e \u003cp\u003e37. General Strategy C: Strategy of Ring Synthesis 279\u003c\/p\u003e \u003cp\u003e38. Strategy XVII: Stereoselectivity B 289\u003c\/p\u003e \u003cp\u003e39. Aromatic Heterocycles 301\u003c\/p\u003e \u003cp\u003e40. General Strategy D: Advanced Strategy 313\u003c\/p\u003e \u003cp\u003eIndex 325\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52278023848216,"sku":"9780470712375","price":101.57,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470712375.jpg?v=1781456110","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/organic-synthesis-the-disconnection-approach-hardback-9780470712375","provider":"Freshly Printed Books","version":"1.0","type":"link"}