{"product_id":"neuronal-nicotinic-receptors-pharmacology-and-therapeutic-opportunities-hardback-9780471247432","title":"Neuronal Nicotinic Receptors; Pharmacology and Therapeutic Opportunities (Hardback) 9780471247432","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eNeuronal Nicotinic Receptors\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003ePharmacology and Therapeutic Opportunities\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eStephen P. Arneric (Edited by), SP Arneric (Author), Jorge D. Brioni (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780471247432, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 2 February 1999\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e421 pages\u003cbr\u003e24.2 x 16 x 2.8 cm, 0.771 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"The book consists of a collection of 23 reviewers of 'things nicotonic' written by many...of the world's leaders in the field. Nearly without exception the chapters are chock full of valuable information.\" --Journal of Medicinal Chemistry, Vol. 42, No. 15, 1999\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eNeuronal Nicotinic Receptors: Pharmacology and TherapeuticOpportunities\u003cbr\u003e \u003cbr\u003e Edited by Stephen P. Arneric and Jorge D. Brioni\u003cbr\u003e \u003cbr\u003e Nicotine's efficacy in the treatment of pain and anxiolysis, andits usefulness as a memory enhancer, have been suspected for manyyears, but research into the molecular biology of nicotinicacetylcholine receptors (nAChRs) traditionally has focused onsmoking cessation. Now, thanks to recent technological advances inthe molecular biology and electrophysiology of nAChRs, an abundanceof evidence has emerged in support of nAChR ligands in thetreatment of a range of CNS disorders, including Alzheimer'sdisease, Parkinson's disease, neuropathic pain, attention deficitdisorder, and depression.\u003cbr\u003e \u003cbr\u003e Featuring contributions from an international team of experts inthe field, this volume provides researchers and clinicians with acomprehensive review of nAChRs, their molecular biology,pharmacology, and clinical implications. Moving from the molecularto the clinical levels, the authors explore the latest developmentsin all areas of nAChR research, including:\u003cbr\u003e * Molecular biology and biochemistry of nAChRs\u003cbr\u003e * The physiological roles of nAChRs\u003cbr\u003e * Pharmacokinetics of nicotine-like alkaloids\u003cbr\u003e * Recent breakthroughs and emerging trends in nAChR medicinalchemistry\u003cbr\u003e * Current and emerging therapeutic applications of novel nAChRligands.\u003cbr\u003e \u003cbr\u003e A timely, authoritative review of basic research into nAChRs andtheir role in the development of new therapeutic strategies in thetreatment of a range of various CNS diseases, Neuronal NicotinicReceptors: Pharmacology and Therapeutic Opportunities is requiredreading for neuroscientists, pharmacologists, medicinal chemists,biological psychiatrists, and psychopharmacologists.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eMOLECULAR BIOLOGY AND BIOCHEMISTRY.\u003cbr\u003e \u003cbr\u003e Purification and Cloning of Nicotinic Acetylcholine Receptors (J.Lindstrom).\u003cbr\u003e \u003cbr\u003e Transcriptional Regulation of Neuronal Nicotinic Receptor SubunitGenes (D. Fornasari, et al.).\u003cbr\u003e \u003cbr\u003e Molecular Composition and Biophysical Characteristics of NicotinicReceptors (J. Ramirez-Latorre, et al.).\u003cbr\u003e \u003cbr\u003e Desensitization and the Regulation of Neuronal Nicotinic Receptors(M. Marks).\u003cbr\u003e \u003cbr\u003e Cell Lines as Models for Studies of Nicotinic AcetylcholineReceptors (R. Lukas).\u003cbr\u003e \u003cbr\u003e Stable Expression of Human Neuronal Nicotinic Receptors (B.Buisson, et al.).\u003cbr\u003e \u003cbr\u003e PHYSIOLOGICAL ROLES OF NICOTINIC RECEPTORS.\u003cbr\u003e \u003cbr\u003e Functional Anatomy of Nicotinic Acetylcholine Receptors inMammalian Brain (P. Clarke).\u003cbr\u003e \u003cbr\u003e Nicotinic Receptor Modulation of Neurotransmitter Release (S.Kaiser \u0026amp; S. Wonnacott).\u003cbr\u003e \u003cbr\u003e Functional Diversity of Nicotinic Acetylcholine Receptors in theMammalian Central Nervous System: Physiological Relevance (E.Pereira, et al.).\u003cbr\u003e \u003cbr\u003e Diverse Functions of Neuronal Nicotinic Receptors Determined bySubcellular Location (D. Berg, et al.).\u003cbr\u003e \u003cbr\u003e Immunosuppressive and Anti-inflammatory Properties of Nicotine (M.Sopori).\u003cbr\u003e \u003cbr\u003e PHARMACOKINETICS OF NICOTINE-LIKE ALKALOIDS.\u003cbr\u003e \u003cbr\u003e Pharmacokinetics and Metabolism of Nicotine and Related Alkaloids(N. Benowitz \u0026amp; P. Jacob).\u003cbr\u003e \u003cbr\u003e Nicotine and Related Compounds as PET and SPECT Ligands (V.Villemagne, et al).\u003cbr\u003e \u003cbr\u003e MEDICINAL CHEMISTRY.\u003cbr\u003e \u003cbr\u003e Natural Products as a Source of Nicotinic Acetylcholine ReceptorModulators and Leads for Drug Discovery (M. Holladay, etal.).\u003cbr\u003e \u003cbr\u003e Nicotinic Cholinergic Receptor Pharmacophores (R. Glennon \u0026amp; M.Dukat).\u003cbr\u003e \u003cbr\u003e CURRENT AND POTENTIAL THERAPEUTIC APPLICATIONS.\u003cbr\u003e \u003cbr\u003e Neuronal Nicotinic Receptor Channel Dysfunction in a Human EpilepsySyndrome (D. Bertrand \u0026amp; S. Berkovic).\u003cbr\u003e \u003cbr\u003e The Role of Nicotine and Nicotinic Receptors in Psychopathology (S.Leonard, et al.).\u003cbr\u003e \u003cbr\u003e Nicotine and Non-Nicotine Formulations for Smoking Cessation (S.Leischow \u0026amp; G. Cook).\u003cbr\u003e \u003cbr\u003e Preclinical Evidence on the Neuroprotective Effects of NicotinicLigands (D. Donnelly-Roberts \u0026amp; J. Brioni).\u003cbr\u003e \u003cbr\u003e Transdermal Nicotine Treatment of Attention Deficit HyperactivityDisorder (E. Levin, et al.).\u003cbr\u003e \u003cbr\u003e Neuronal Nicotinic Receptors: New Targets in the Treatment of Pain(C. Flores \u0026amp; K. Hargreaves).\u003cbr\u003e \u003cbr\u003e Subtype-Selective nAChR Agonists for the Treatment of NeurologicalDisorders: SIB-1508Y and SIB-1553A (F. Menzaghi, et al.).\u003cbr\u003e \u003cbr\u003e Nicotinic Acetylcholine Receptor-Targeted Compounds: A Summary ofthe Development Pipeline and Therapeutic Potential (M. Decker \u0026amp;S. Arneric).\u003cbr\u003e \u003cbr\u003e Index.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Other branches of medicine [\u003ca title=\"See our other books on Other branches of medicine\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Other%20branches%20of%20medicine%20%5BMM%5D%22\"\u003eMM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Liss","offers":[{"title":"Brand New","offer_id":52286355800344,"sku":"9780471247432","price":257.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780471247432.jpg?v=1781550532","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/neuronal-nicotinic-receptors-pharmacology-and-therapeutic-opportunities-hardback-9780471247432","provider":"Freshly Printed Books","version":"1.0","type":"link"}