{"product_id":"nanomaterials-in-drug-delivery-imaging-and-tissue-engineering-hardback-9781118290323","title":"Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering (Hardback) 9781118290323","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eNanomaterials in Drug Delivery, Imaging, and Tissue Engineering\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eAshutosh Tiwari (Edited by), A Tiwari (Author), Atul Tiwari (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781118290323, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 19 March 2013\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e576 pages\u003cbr\u003e24.3 x 16.5 x 3.6 cm, 0.939 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e“The volume was written by many scientists working in the new area of nanotechnology. Each chapter has an extensive reference list and there is a short index at the end.”  (\u003ci\u003eOptics \u0026amp; Photonics News\u003c\/i\u003e, 22 November 2013)\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eThis comprehensive volume provides the reader valuable insight into the major areas of biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and cutting-edge nanoscaffolds.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe ability to control the structure of materials allows scientists to accomplish what once appeared impossible before the advent of nanotechnology. It is now possible to generate nanoscopic self-assembled and self-destructive robots for effective utilization in therapeutics, diagnostics, and biomedical implants. Nanoscopic therapeutic systems incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities and they have emerged as the next generation of multifarious nanomedicine to improve the therapeutic outcome including chemo and translational therapy.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eNanomaterials in Drug Delivery, Imaging, and Tissue Engineering\u003c\/i\u003e comprises fifteen chapters authored by senior scientists, and is one of the first books to cover nanotheragnostics, which is the new developmental edge of nanomedicine combining both diagnostic and therapeutic elements at the nano level. This large multidisciplinary reference work has four main parts: biomedical nanomaterials; advanced nanomedicine; nanotheragnostics; and nanoscaffolds technology.\u003c\/p\u003e \u003cp\u003eThis groundbreaking volume also covers:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eMultifunctional polymeric nanostructures for therapy and diagnosis\u003c\/li\u003e \u003cli\u003eMetalla-assemblies acting as drug carriers\u003c\/li\u003e \u003cli\u003eNanomaterials for management of lung disorders and drug delivery\u003c\/li\u003e \u003cli\u003eResponsive polymer-inorganic hybrid nanogels for optical sensing, imaging, and drug delivery\u003c\/li\u003e \u003cli\u003eCore\/shell nanoparticles for drug delivery and diagnosis\u003c\/li\u003e \u003cli\u003eTheranostic nanoparticles for cancer imaging and therapy\u003c\/li\u003e \u003cli\u003eMagnetic nanoparticles in tissue regeneration\u003c\/li\u003e \u003cli\u003eCore-sheath fibers for regenerative medicine\u003c\/li\u003e \u003c\/ul\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface xv  \u003cp\u003e\u003cb\u003ePart I: Biomedical nanomaterials\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Nanoemulsions: Preparation, Stability and Application in Biosciences 1\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eThomas Delmas, Nicolas Atrux-Tallau, Mathieu Goutayer, SangHoon Han, Jin Woong Kim, and Jérôme Bibette\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 2\u003c\/p\u003e \u003cp\u003e1.2 Nanoemulsion:A Thermodynamic Definition and Its Practical Implications 5\u003c\/p\u003e \u003cp\u003e1.2.1 Generalities on Emulsions 5\u003c\/p\u003e \u003cp\u003e1.2.2 Nanoemulsion vs. Microemulsion, a Thermodynamic Definition 6\u003c\/p\u003e \u003cp\u003e1.3 Stable Nanoemulsion Formulation 9\u003c\/p\u003e \u003cp\u003e1.3.1 Nanoemulsion Production 9\u003c\/p\u003e \u003cp\u003e1.3.2 Nanoemulsion Stability Rules 11\u003c\/p\u003e \u003cp\u003e1.3.3 Nanoemulsion Formulation Domain 16\u003c\/p\u003e \u003cp\u003e1.3.4 Conclusion on the Formulation of Stable Nanoemulsions 21\u003c\/p\u003e \u003cp\u003e1.4 Nanoencapsulation in Lipid Nanoparticles 21\u003c\/p\u003e \u003cp\u003e1.4.1 Aim ofActive Encapsulation 21\u003c\/p\u003e \u003cp\u003e1.4.2 Lipid Complexity and Influence of Their Physical State 23\u003c\/p\u003e \u003cp\u003e1.4.3 Amorphous Lipids for a Large Range of Encapsulated Molecules 27\u003c\/p\u003e \u003cp\u003e1.4.4 Lipids Viscosity and Release 31\u003c\/p\u003e \u003cp\u003e1.4.5 Conclusion on the Use ofAmorphous Lipid Matrices for Control OverActive Encapsulation and Release 34\u003c\/p\u003e \u003cp\u003e1.5 Interactions between Nanoemulsions and the Biological Medium: Applications in Biosciences 35\u003c\/p\u003e \u003cp\u003e1.5.1 Nanoemulsion Biocompatibility 35\u003c\/p\u003e \u003cp\u003e1.5.2 Classical TargetingApproach by Chemical Grafting – Example of Tumor Cell Targeting by Crgd Peptide for Cancer Diagnosis and Therapy 38\u003c\/p\u003e \u003cp\u003e1.5.3 New ‘No Synthesis Chemistry’Approach – Example of Pal-KTTKS andAsiaticoside Targeting for CosmeticActives Delivery 41\u003c\/p\u003e \u003cp\u003e1.5.4 Conclusion on Nanoemulsions Application in Biosciences 46\u003c\/p\u003e \u003cp\u003e1.6 General Conclusion 47\u003c\/p\u003e \u003cp\u003eReferences 48\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Multifunctional Polymeric Nanostructures for Therapy and Diagnosis 57\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAngel Contreras-García and Emilio Bucio\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 58\u003c\/p\u003e \u003cp\u003e2.2 Polymeric-based Core-shell Colloid 61\u003c\/p\u003e \u003cp\u003e2.3 Proteins and Peptides 64\u003c\/p\u003e \u003cp\u003e2.4 Drug Conjugates and Complexes with Synthetic Polymers 65\u003c\/p\u003e \u003cp\u003e2.5 Dendrimers, Vesicles, and Micelles 67\u003c\/p\u003e \u003cp\u003e2.5.1 Dendrimers 67\u003c\/p\u003e \u003cp\u003e2.5.2 Vesicles 68\u003c\/p\u003e \u003cp\u003e2.5.3 Micelles 70\u003c\/p\u003e \u003cp\u003e2.6 Smart Nanopolymers 71\u003c\/p\u003e \u003cp\u003e2.6.1 Temperature and pH Stimuli-responsive Nanopolymers 72\u003c\/p\u003e \u003cp\u003e2.6.2 Hydrogels 72\u003c\/p\u003e \u003cp\u003e2.6.3 Stimuli Responsive Biomaterials 73\u003c\/p\u003e \u003cp\u003e2.6.4 Interpenetrating Polymer Networks 74\u003c\/p\u003e \u003cp\u003e2.7 Stimuli Responsive Polymer-metal Nanocomposites  75\u003c\/p\u003e \u003cp\u003e2.8 Enzyme-responsive Nanoparticles 78\u003c\/p\u003e \u003cp\u003eAcknowledgements 83\u003c\/p\u003e \u003cp\u003eReferences 83\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Carbon Nanotubes: Nanotoxicity Testing and Bioapplications 97\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eR. Sharma and S. Kwon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 98\u003c\/p\u003e \u003cp\u003e3.1.1 What is Nanotoxicity of Nanomaterials? 98\u003c\/p\u003e \u003cp\u003e3.2 Historical Review of Carbon Nanotube 99\u003c\/p\u003e \u003cp\u003e3.3 Carbon Nanotubes (CNTs) and Other Carbon Nanomaterials 100\u003c\/p\u003e \u003cp\u003e3.3.1 Physical Principles of Carbon Nanotube Surface Science 102\u003c\/p\u003e \u003cp\u003e3.4 Motivation – Combining Nanotechnology and Surface Science with Growing Bioapplications 104\u003c\/p\u003e \u003cp\u003e3.5 Cytotoxicity Measurement and Mechanisms of CNT Toxicity 111\u003c\/p\u003e \u003cp\u003e3.1.6 In Vivo Studies on CNT Toxicity 113\u003c\/p\u003e \u003cp\u003e3.1.7 Inflammatory Mechanism of CNT Cytoxicity 114\u003c\/p\u003e \u003cp\u003e3.1.8 Characterization and Toxicity of SWCNT and MWCNT Carbon Nanotubes 116\u003c\/p\u003e \u003cp\u003e3.6 MSCs Differentiation and Proliferation on Different Types of Scaffolds 120\u003c\/p\u003e \u003cp\u003e3.6.1 An In Vivo Model CNT-Induced Inflammatory Response in Alveolar Co-culture System 122\u003c\/p\u003e \u003cp\u003e3.6.2 Static Model: 3-Dimensional Tissue Engineered Lung 124\u003c\/p\u003e \u003cp\u003e3.6.3 Dynamic Model: Integration of 3D Engineered Tissues into Cyclic Mechanical Strain Device 126\u003c\/p\u003e \u003cp\u003e3.6.4 In Vivo MR Microimaging Technique of Rat Skin Exposed to CNT 127\u003c\/p\u003e \u003cp\u003e3.7 New Lessons on CNT Nanocomposites 130\u003c\/p\u003e \u003cp\u003e3.8 Conclusions 135\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Advanced nanomedicine\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Discrete Metalla-Assemblies as Drug Delivery Vectors 149\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eBruno Therrien\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 149\u003c\/p\u003e \u003cp\u003e4.2 Complex-in-a-Complex Systems 150\u003c\/p\u003e \u003cp\u003e4.3 Encapsulation of Pyrenyl-functionalized Derivatives 155\u003c\/p\u003e \u003cp\u003e4.4 Exploiting the Enhanced Permeability and Retention Effect 159\u003c\/p\u003e \u003cp\u003e4.5 Incorporation of Photosensitizers in Metalla-assemblies 162\u003c\/p\u003e \u003cp\u003e4.6 Conclusion 165\u003c\/p\u003e \u003cp\u003eAcknowledgments 165\u003c\/p\u003e \u003cp\u003eReferences 166\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Nanomaterials for Management of Lung Disorders and Drug Delivery 169\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJyothi U. Menon, Aniket S. Wadajkar, Zhiwe iXie, and Kytai T. Nguyen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Lung Structure and Physiology 170\u003c\/p\u003e \u003cp\u003e5.2 Common Lung DiseasesAnd Treatment Methods 171\u003c\/p\u003e \u003cp\u003e5.2.1 Lung Cancer 171\u003c\/p\u003e \u003cp\u003e5.2.2 PulmonaryArterial Hypertension 172\u003c\/p\u003e \u003cp\u003e5.2.3 Obstructive Lung Diseases 173\u003c\/p\u003e \u003cp\u003e5.3 Types of Nanoparticles (NPs) 173\u003c\/p\u003e \u003cp\u003e5.3.1 Liposomes 174\u003c\/p\u003e \u003cp\u003e5.3.2 Micelles 176\u003c\/p\u003e \u003cp\u003e5.3.3 Dendrimers 177\u003c\/p\u003e \u003cp\u003e5.3.4 Polymeric Micro\/Nanoparticles 177\u003c\/p\u003e \u003cp\u003e5.4 Methods for Pulmonary Delivery 179\u003c\/p\u003e \u003cp\u003e5.4.1 Nebulization 179\u003c\/p\u003e \u003cp\u003e5.4.2 Metered Dose Inhalation (MDI) 182\u003c\/p\u003e \u003cp\u003e5.4.3 Dry Powder Inhalation (DPI) 183\u003c\/p\u003e \u003cp\u003e5.4.4 IntratrachealAdministration 183\u003c\/p\u003e \u003cp\u003e5.5 Targeting Mechanisms 184\u003c\/p\u003e \u003cp\u003e5.5.1 Passive Targeting 184\u003c\/p\u003e \u003cp\u003e5.5.2 Active Targeting 185\u003c\/p\u003e \u003cp\u003e5.5.3 Cellular Uptake Mechanisms 188\u003c\/p\u003e \u003cp\u003e5.6 TherapeuticAgents Used for Delivery 188\u003c\/p\u003e \u003cp\u003e5.6.1 ChemotherapeuticAgents 188\u003c\/p\u003e \u003cp\u003e5.6.2 Bioactive Molecules 190\u003c\/p\u003e \u003cp\u003e5.6.3 Combinational Therapy 190\u003c\/p\u003e \u003cp\u003e5.7 Applications 191\u003c\/p\u003e \u003cp\u003e5.7.1 Imaging\/DiagnosticApplications 191\u003c\/p\u003e \u003cp\u003e5.7.2 TherapeuticApplications 193\u003c\/p\u003e \u003cp\u003e5.7.3 Lung Remodeling and Regeneration 194\u003c\/p\u003e \u003cp\u003e5.8 Design Considerations of NPs 195\u003c\/p\u003e \u003cp\u003e5.8.1 Half-life of NPs 195\u003c\/p\u003e \u003cp\u003e5.8.2 Drug Release Mechanisms 195\u003c\/p\u003e \u003cp\u003e5.8.3 Clearance Mechanisms in the Lung 196\u003c\/p\u003e \u003cp\u003e5.9 Current Challenges and Future Outlook 197\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Nano-Sized Calcium Phosphate (CaP) Carriers for Non-Viral Gene\/Drug Delivery 199\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDonghyun Lee, Geunseon Ahn and Prashant N. Kumta\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 200\u003c\/p\u003e \u003cp\u003e6.2 Vectors for Gene Delivery 202\u003c\/p\u003e \u003cp\u003e6.2.1 Viral Vectors 203\u003c\/p\u003e \u003cp\u003e6.2.2 Non-viral Vectors 203\u003c\/p\u003e \u003cp\u003e6.2.3 Calcium Phosphate Vectors 205\u003c\/p\u003e \u003cp\u003e6.3 Modulation of Protection and Release Characteristics of Calcium Phosphate Vector 213\u003c\/p\u003e \u003cp\u003e6.4 Calcium Phosphate Carriers for Drug Delivery Systems 219\u003c\/p\u003e \u003cp\u003e6.4.1 Antibiotics Delivery 219\u003c\/p\u003e \u003cp\u003e6.4.2 Growth Factor Delivery 221\u003c\/p\u003e \u003cp\u003e6.5 Variants of Nano-calcium Phosphates: Future Trends of the CaPDelivery Systems 221\u003c\/p\u003e \u003cp\u003eAcknowledgements 223\u003c\/p\u003e \u003cp\u003eReferences 223\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Organics ModifiedMesoporous Silica for Controlled Drug Delivery Systems 233\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJingke Fu, Yang Zhao, Yingchun Zhu and Fang Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 233\u003c\/p\u003e \u003cp\u003e7.2 Controlled Drug Delivery Systems Based on Organics Modified\u003c\/p\u003e \u003cp\u003e7.2.1 MSNs-based Drug Delivery Systems Controlled by Physical Stimuli 238\u003c\/p\u003e \u003cp\u003e7.2.2 MSNs-based Drug Delivery Systems Controlled by Chemical Stimuli 246\u003c\/p\u003e \u003cp\u003e7.3 Conclusions 258\u003c\/p\u003e \u003cp\u003eReferences 259\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III: Nanotheragnostics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Responsive Polymer-Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery 263\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eWeitai Wu and Shuiqin Zhou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 264\u003c\/p\u003e \u003cp\u003e8.2 Mechanisms of Response 268\u003c\/p\u003e \u003cp\u003e8.2.1 Reception of an External Signal 268\u003c\/p\u003e \u003cp\u003e8.2.2 Volume Phase Transition of the Hybrid Nanogels 275\u003c\/p\u003e \u003cp\u003e8.2.4 Regulated Drug Delivery 282\u003c\/p\u003e \u003cp\u003e8.3 Synthesis of Responsive Polymer-inorganic Hybrid Nanogels 285\u003c\/p\u003e \u003cp\u003e8.3.1 Synthesis of the Hybrid Nanogels from Pre-synthesized Polymer Nanogels 285\u003c\/p\u003e \u003cp\u003e8.3.2 Synthesis of the Hybrid Nanogels from Pre-synthesized Inorganic NPs 289\u003c\/p\u003e \u003cp\u003e8.3.3 Synthesis of the Hybrid Nanogels by a Heterogeneous Polymerization Method 292\u003c\/p\u003e \u003cp\u003e8.4 Applications 293\u003c\/p\u003e \u003cp\u003e8.4.1 Responsive Polymer-inorganic Hybrid Nanogels in Optical Sensing 293\u003c\/p\u003e \u003cp\u003e8.4.2 Responsive Polymer-inorganic Hybrid Nanogels in Diagnostic Imaging 299\u003c\/p\u003e \u003cp\u003e8.4.3 Responsive Polymer-inorganic Hybrid Nanogels in Drug Delivery 301\u003c\/p\u003e \u003cp\u003eReferences 306\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Core\/Shell Nanoparticles for Drug Delivery and Diagnosis 315\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHwanbum Lee, Jae Yeon Kim, Eun Hee Lee, Young In Park, Keun Sang Oh, Kwangmeyung Kim, Ick Chan Kwonand Soon Hong Yuk\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.2 Core\/Shell NPs from Polymeric Micelles 319\u003c\/p\u003e \u003cp\u003e9.2.1 Polymeric Micelles with Physical Drug Entrapment 319\u003c\/p\u003e \u003cp\u003e9.2.2 Polymeric Micelles with Drug Conjugation 321\u003c\/p\u003e \u003cp\u003e9.2.3 Polymeric Micelles Formed by Temperature-Induced Phase Transition 323\u003c\/p\u003e \u003cp\u003e9.3 Phospholipid-based Core\/Shell Nanoparticles 325\u003c\/p\u003e \u003cp\u003e9.4 Layer-by-Layer-Assembled Core\/Shell Nanoparticles 329\u003c\/p\u003e \u003cp\u003e9.5 Core\/Shell NPs for Diagnosis 330\u003c\/p\u003e \u003cp\u003e9.4 Conclusions 331\u003c\/p\u003e \u003cp\u003eAcknowledgments 331\u003c\/p\u003e \u003cp\u003eReferences 331\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Dendrimer Nanoparticles and Their Applications in Biomedicine 339\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eArghya Paul, Wei Shao, Tom J. Burdon, Dominique Shum-Tim and Satya Prakash\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1  Introduction 340\u003c\/p\u003e \u003cp\u003e10.2  Dendrimers and Their Characteristics 341\u003c\/p\u003e \u003cp\u003e10.3  Biomolecular Interactions of Dendrimer Nanocomplexes 343\u003c\/p\u003e \u003cp\u003e10.3.1  Genes (siRNA\/ANS\/DNA) 344\u003c\/p\u003e \u003cp\u003e10.3.2  Drugs and Pharmaceutics 345\u003c\/p\u003e \u003cp\u003e10.4  PotentialApplications of Dendrimer in Nanomedicine 347\u003c\/p\u003e \u003cp\u003e10.4.1  Delivery of Chemotherapeutics 347\u003c\/p\u003e \u003cp\u003e10.4.2  Delivery of Biomolecules 348\u003c\/p\u003e \u003cp\u003e10.4.3  Imaging 350\u003c\/p\u003e \u003cp\u003e10.5  Conclusion 353\u003c\/p\u003e \u003cp\u003eAcknowledgements 355\u003c\/p\u003e \u003cp\u003eIndexing words 355\u003c\/p\u003e \u003cp\u003eReferences 355\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Theranostic Nanoparticles for Cancer Imaging and Therapy 363\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMami Murakami, Mark J. Ernsting and Shyh-Dar Li\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1  Introduction 363\u003c\/p\u003e \u003cp\u003e11.2  Multifunctional Nanoparticles for Noninvasive\u003c\/p\u003e \u003cp\u003e11.2.1 Radiolabeled Nanoparticles 366\u003c\/p\u003e \u003cp\u003e11.2.2 Fluorescence Imaging of Biodistribution 367\u003c\/p\u003e \u003cp\u003e11.2.3 Multimodal Radiolabel and Fluorescence Imaging of Biodistribution 368\u003c\/p\u003e \u003cp\u003e11.2.4 MRI Imaging of Biodistribution 369\u003c\/p\u003e \u003cp\u003e11.2.5 Multimodal MRI and Fluorescence Imaging of Biodistribution 371\u003c\/p\u003e \u003cp\u003e11.2.6 Multimodal Optical and CT Imaging of Biodistribution 372\u003c\/p\u003e \u003cp\u003e11.2.7 Pharmacokinetics and Pharmacodynamics of Theranostics vs Diagnostics 373\u003c\/p\u003e \u003cp\u003e11.3  Multifunctional Nanoparticles for Monitoring Drug Release 375\u003c\/p\u003e \u003cp\u003e11.3.1 MRI imaging of Drug Release 375\u003c\/p\u003e \u003cp\u003e11.3.2 Fluorescent Imaging of Drug Release 379\u003c\/p\u003e \u003cp\u003e11.4  Theranostics to Image Therapeutic Response 380\u003c\/p\u003e \u003cp\u003e11.5  Conclusion and Future Directions 382\u003c\/p\u003e \u003cp\u003eAcknowledgement 383\u003c\/p\u003e \u003cp\u003eReferences 383\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV: Nanoscaffolds technology\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Nanostructure Polymers in Function Generating Substitute and Organ Transplants 389\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eS.K. Shukla\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1  Introduction 389\u003c\/p\u003e \u003cp\u003e12.2  Important Nanopolymers 391\u003c\/p\u003e \u003cp\u003e12.2.1 Hydrogels 393\u003c\/p\u003e \u003cp\u003e12.2.2 Bioceramics 394\u003c\/p\u003e \u003cp\u003e12.2.3 Bioelastomers 395\u003c\/p\u003e \u003cp\u003e12.2.4 Chitosan and Derivatives 396\u003c\/p\u003e \u003cp\u003e12.2.5 Gelatine 396\u003c\/p\u003e \u003cp\u003e12.3  MedicalApplications 397\u003c\/p\u003e \u003cp\u003e12.3.1 Tissue Engineering for Function Generating 398\u003c\/p\u003e \u003cp\u003e12.3.2 Tissue Engineering inArtificial Heart 400\u003c\/p\u003e \u003cp\u003e12.3.3 Tissue Engineering in Nervous System 401\u003c\/p\u003e \u003cp\u003e12.3.4 Bone Transplants 404\u003c\/p\u003e \u003cp\u003e12.3.5 Kidney and Membrane Transplants 406\u003c\/p\u003e \u003cp\u003e12.3.6 Miscellaneous 409\u003c\/p\u003e \u003cp\u003eAcknowledgement 411\u003c\/p\u003e \u003cp\u003eReferences 411\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Electrospun Nanofiberfor Three Dimensional Cell Culture 417\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eYashpal Sharma, Ashutosh Tiwari and Hisatoshi Kobayashi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1  Introduction 417\u003c\/p\u003e \u003cp\u003e13.2  Nanofiber Scaffolds Fabrication Techniques 419\u003c\/p\u003e \u003cp\u003e13.2.1 Self-Assembly 419\u003c\/p\u003e \u003cp\u003e13.2.2 Phase Separation 421\u003c\/p\u003e \u003cp\u003e13.2.3 Electrospinning 422\u003c\/p\u003e \u003cp\u003e13.3  Parameters of Electrospinning Process 424\u003c\/p\u003e \u003cp\u003e13.3.1 Viscosity or Concentration of the Polymeric Solution 424\u003c\/p\u003e \u003cp\u003e13.3.2 Conductivity and the Charge Density 425\u003c\/p\u003e \u003cp\u003e13.3.3 Molecular Weight of Polymer 425\u003c\/p\u003e \u003cp\u003e13.3.4 Flow Rate 425\u003c\/p\u003e \u003cp\u003e13.3.5 Distance from Tip to Collector 425\u003c\/p\u003e \u003cp\u003e13.3.6 VoltageApplied 426\u003c\/p\u003e \u003cp\u003e13.3.7 Environmental Factors 426\u003c\/p\u003e \u003cp\u003e13.4  Electrospun Nanofibers for Three-dimensional Cell Culture 426\u003c\/p\u003e \u003cp\u003e13.5  Conclusions 429\u003c\/p\u003e \u003cp\u003eReferences 431\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Magnetic Nanoparticles in Tissue Regeneration 435\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAnuj Tripathi, Jose Savio Melo and Stanislaus Francis D’Souza\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1  Introduction 435\u003c\/p\u003e \u003cp\u003e14.2  Magnetic Nanoparticles: Physical Properties 438\u003c\/p\u003e \u003cp\u003e14.3  Synthesis of Magnetic Nanoparticles 440\u003c\/p\u003e \u003cp\u003e14.4  Design and Structure of Magnetic Nanoparticles 443\u003c\/p\u003e \u003cp\u003e14.5  Stability and Functionalization of Magnetic Nanoparticles 445\u003c\/p\u003e \u003cp\u003e14.6  Cellular Toxicity of Magnetic Nanoparticles 450\u003c\/p\u003e \u003cp\u003e14.7  Tissue EngineeringApplications of Magnetic Nanoparticles 453\u003c\/p\u003e \u003cp\u003e14.7.1 Magnetofection 455\u003c\/p\u003e \u003cp\u003e14.7.2 Cell-patterning 458\u003c\/p\u003e \u003cp\u003e14.7.3 Magnetic Force-induced Tissue Fabrication 461\u003c\/p\u003e \u003cp\u003e14.8  Challenges and Future Prospects 473\u003c\/p\u003e \u003cp\u003eAcknowledgement 474\u003c\/p\u003e \u003cp\u003eReferences 474\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Core-sheath Fibersfor Regenerative Medicine 485\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRajesh Vasita and Fabrizio Gelain\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1  Introduction 486\u003c\/p\u003e \u003cp\u003e15.1.1 Tissue Engineering 487\u003c\/p\u003e \u003cp\u003e15.1.2 Scaffold Fabrication Technology 488\u003c\/p\u003e \u003cp\u003e15.2  Core-sheath Nanofiber Technology 489\u003c\/p\u003e \u003cp\u003e15.2.1 Co-axial Electrospinning 491\u003c\/p\u003e \u003cp\u003e15.2.2 Emulsion Electrospinning 501\u003c\/p\u003e \u003cp\u003e15.2.3 Melt Co-axial Electrospinning 503\u003c\/p\u003e \u003cp\u003e15.3Application of Core-sheath Nanofibers 504\u003c\/p\u003e \u003cp\u003e15.3.1 Delivery of Bioactive Molecules 504\u003c\/p\u003e \u003cp\u003e15.3.2 Tissue Engineering 513\u003c\/p\u003e \u003cp\u003e15.4  Conclusions 519\u003c\/p\u003e \u003cp\u003eReferences 519\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Other branches of medicine [\u003ca title=\"See our other books on Other branches of medicine\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Other%20branches%20of%20medicine%20%5BMM%5D%22\"\u003eMM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Scrivener","offers":[{"title":"Brand 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