{"product_id":"molecular-pathology-in-drug-discovery-and-development-hardback-9780470145593","title":"Molecular Pathology in Drug Discovery and Development (Hardback) 9780470145593","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eMolecular Pathology in Drug Discovery and Development\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eJ. Suso Platero (Edited by), JS Platero (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470145593, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 11 September 2009\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e400 pages\u003cbr\u003e23.6 x 15.5 x 2.3 cm, 0.68 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e“\u003ci\u003eMolecular Pathology in Drug Discovery and Development\u003c\/i\u003e is a well-written book that provides both an overview of how biomarkers may be developed and detailed explanations of how to measure and analyze said biomarkers.”  (\u003ci\u003eThe Yale Journal of Biology and Medicine,\u003c\/i\u003e March 2010)\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eCovers powerful new tools for drug development\u003c\/p\u003e \u003cp\u003eMolecular pathology offers tools and techniques that can greatly enhance the drug discovery and development process, helping to make the promises of personalized medicine a reality. Molecular Pathology in Drug Discovery and Development provides an unmatched guide to this cutting-edge discipline and its applications to pharmaceutical science.\u003c\/p\u003e \u003cp\u003eWith contributions from leading lights in drug discovery, drug development, and molecular pathology balanced by a consistent editorial approach, this reference offers both an overview of molecular pathology and a close look at the methods as they are applied to the process of drug discovery and development. Presented as steps in the drug development process, the coverage includes the use of molecular pathology to:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eIdentify and validate new drug candidates\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eEnhance transcriptional profiling to better find and validate biomarkers\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eAssess toxicology\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eEmploy toxicogenomics to identify genes relevant to the safety of compounds\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eIdentify correct doses for different drugs\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eIdentify patients for treatment\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eDevelop molecular therapies\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eFurther the new techniques of Immunohistochemistry and Immunofluorescence\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWith many tests and treatments already working today, drug research and development using molecular pathology has shown itself an extremely fruitful area. Molecular Pathology in Drug Discovery and Development gives practitioners an up-to-date resource on this highly active discipline and its role in furthering pharmaceutical research.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cb\u003ePreface.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eContributors.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 MOLECULAR PATHOLOGY AND DRUG DEVELOPMENT\u003c\/b\u003e \u003ci\u003e(Franz Fogt and J. Suso Platero).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1. General Pathology.\u003c\/p\u003e \u003cp\u003e1.2. General Aspects.\u003c\/p\u003e \u003cp\u003e1.3. Molecular Pathology, the Molecular Way.\u003c\/p\u003e \u003cp\u003e1.4. Application of Molecular Pathology.\u003c\/p\u003e \u003cp\u003e1.5. Molecular Pathology in Drug Development.\u003c\/p\u003e \u003cp\u003e1.6. Pharmaceutical Drug Development.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 MOLECULAR PATHOLOGY IN ONCOLOGY TARGET AND DRUG DISCOVERY\u003c\/b\u003e \u003ci\u003e(Rolf-P. Ryseck, Ricardo Attar, Matthew V. Lorenzi, and Brent A. Rupnow).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1. Introduction.\u003c\/p\u003e \u003cp\u003e2.2. History of Chemotherapy and Cancer Drug Discovery.\u003c\/p\u003e \u003cp\u003e2.3. Target-Based Drug Discovery.\u003c\/p\u003e \u003cp\u003e2.4. Utilization of Molecular Pathology in the Discovery of Novel Cancer Targets.\u003c\/p\u003e \u003cp\u003e2.5. Hit Identifi cation and In Vitro Lead Optimization.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e2.6. Implications for Molecular Pathology in Cancer Drug Development and Use.\u003c\/p\u003e \u003cp\u003e2.7. Summary and Future Considerations.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 MOLECULAR PATHOLOGY AND TRANSCRIPTIONAL PROFILING IN EARLY DRUG DEVELOPMENT\u003c\/b\u003e \u003ci\u003e(Cornelia Liedtke, Lajos Pusztai, and W. Fraser Symmans).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1. Introduction.\u003c\/p\u003e \u003cp\u003e3.2. Biomarkers in Clinical Setting and in Early Drug Development.\u003c\/p\u003e \u003cp\u003e3.3. Advantages of Biomarker Implementation.\u003c\/p\u003e \u003cp\u003e3.4. Changing Paradigm in Clinical Drug and Biomarker Development.\u003c\/p\u003e \u003cp\u003e3.5. Promises of Transcriptional Profiling.\u003c\/p\u003e \u003cp\u003e3.6. Biomarker Development and Validation Using Microarray Analysis.\u003c\/p\u003e \u003cp\u003e3.7. Neoadjuvant Chemotherapy as an Intriguing Model for Biomarker Development.\u003c\/p\u003e \u003cp\u003e3.8. Transcriptional Profi ling for Identifi cation of Individual Genes as Biomarkers.\u003c\/p\u003e \u003cp\u003e3.9. Transcriptional Profi ling for the Definition of Multigene Predictors Using .Transcriptional Profiling.\u003c\/p\u003e \u003cp\u003e3.10. Novel Tools for Pathway Analysis.\u003c\/p\u003e \u003cp\u003e3.11. Implementation of Biomarkers into the Clinical Setting.\u003c\/p\u003e \u003cp\u003e3.12. Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 MOLECULAR PATHOLOGY IN NONCLINICAL SAFETY ASSESSMENT\u003c\/b\u003e \u003ci\u003e(Richard A. Westhouse).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1. Introduction.\u003c\/p\u003e \u003cp\u003e4.2. Drug Development.\u003c\/p\u003e \u003cp\u003e4.3. Drug Discovery.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e4.4. Biopharmaceuticals.\u003c\/p\u003e \u003cp\u003e4.5. Summary.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 TOXICOGENOMICS IN DRUG DEVELOPMENT\u003c\/b\u003e \u003ci\u003e(Wayne R. Buck and Eric A. G. Blomme).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1. Introduction.\u003c\/p\u003e \u003cp\u003e5.2. Brief Overview of Large-Scale Gene Expression Technologies.\u003c\/p\u003e \u003cp\u003e5.3. Analysis of Microarray Data.\u003c\/p\u003e \u003cp\u003e5.4. Application of Toxicogenomics in Drug Development.\u003c\/p\u003e \u003cp\u003e5.5. Considerations for Toxicogenomic Study Design.\u003c\/p\u003e \u003cp\u003e5.6. Overview of Major Regulatory Developments Related to Use of Toxicogenomics in Drug Discovery and Development.\u003c\/p\u003e \u003cp\u003e5.7. Summary.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 MOLECULAR PATHOLOGY AS A WAY TO FIND THE RIGHT DOSE FOR A DRUG\u003c\/b\u003e \u003ci\u003e(F. Rojo, A. Rovira, S. Serrano, and J. Albanell).\u003cbr\u003e \u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1. Introduction.\u003c\/p\u003e \u003cp\u003e6.2. Anti-EGFR-Targeted Therapies: The Pharmacodynamic Experience.\u003c\/p\u003e \u003cp\u003e6.3. Molecular Pathology with Small Molecules Gefitinib and Erlotinib.\u003c\/p\u003e \u003cp\u003e6.4. Molecular Pathology with Cetuximab and Other Monoclonal Antibodies to EGFR.\u003c\/p\u003e \u003cp\u003e6.5. Proteasome Inhibitors: Pharmacodynamics on Blood Samples.\u003c\/p\u003e \u003cp\u003e6.6. Pharmacodynamics with Rapamycin Analogs.\u003c\/p\u003e \u003cp\u003e6.7. Second Generation of Targeted Therapies: Multitarget Agents.\u003c\/p\u003e \u003cp\u003e6.8. Conclusions and Perspectives: Phase 0 Clinical Trials.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 MOLECULAR PATHOLOGY IN LIFE-CYCLE MANAGEMENT IN DRUG DEVELOPMENT\u003c\/b\u003e \u003ci\u003e(Martha Quezado, Carlos A. Torres-Cabal, and David Berman).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1. Introduction.\u003c\/p\u003e \u003cp\u003e7.2. Molecular Pathology Techniques.\u003c\/p\u003e \u003cp\u003e7.3. Practical Applications of Molecular Pathology Biomarkers.\u003c\/p\u003e \u003cp\u003e7.4. Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 MOLECULAR PATHOLOGY AND MOLECULAR THERAPY\u003c\/b\u003e \u003ci\u003e(Hewei Li).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1. Introduction.\u003c\/p\u003e \u003cp\u003e8.2. Molecular Therapy Strategies.\u003c\/p\u003e \u003cp\u003e8.3. Molecular Therapy Clinical Trials.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 MOLECULAR PATHOLOGY: IMMUNOHISTOCHEMISTRY ASSAYS IN DRUG DEVELOPMENT PERFORMED BY A CONTRACT RESEARCH LABORATORY\u003c\/b\u003e \u003ci\u003e(Frank Lynch and Steve Bernstein).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1. Immunohistochemistry Is the Technique of Microscopic Visualization of Target Proteins in Tissue Sections Using Specific Antibodies.\u003c\/p\u003e \u003cp\u003e9.2. Basics of the IHC Assay.\u003c\/p\u003e \u003cp\u003e9.3. Immunohistochemistry Assay Development.\u003c\/p\u003e \u003cp\u003e9.4. Sending a Study to a Contract Laboratory vs. Running In-house.\u003c\/p\u003e \u003cp\u003e9.5. Choosing and Working with an Outside Laboratory— Keys for a Succe.ssful Relationship—What to Do before a Slide Is Stained.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e9.6. Running and Managing Outsourced Clinical Studies\u003c\/p\u003e \u003cp\u003e9.7. Applications of IHC in Drug Discovery and Development Process.\u003c\/p\u003e \u003cp\u003e9.8. Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 QUANTIFICATION OF MOLECULAR PATHOLOGY: COLORIMETRIC IMMUNOHISTOCHEMISTRY\u003c\/b\u003e \u003ci\u003e(Raphael Marcelpoil).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1. Introduction.\u003c\/p\u003e \u003cp\u003e10.2. Imaging Devices and Systems.\u003c\/p\u003e \u003cp\u003e10.3. Quantifi cation: Introduction to Colorimetric Image Analysis.\u003c\/p\u003e \u003cp\u003e10.4. Measuring Colorimetric Information.\u003c\/p\u003e \u003cp\u003e10.5. Chromogen Separation.\u003c\/p\u003e \u003cp\u003e10.6. Measuring Information.\u003c\/p\u003e \u003cp\u003e10.7. Conclusion.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 AQUA® TECHNOLOGY AND MOLECULAR PATHOLOGY\u003c\/b\u003e \u003ci\u003e(Mark Gustavson, Marisa Dolled-Filhart, Jason Christiansen, Robert Pinard, and David Rimm).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1. Introduction.\u003c\/p\u003e \u003cp\u003e11.2. AQUA Technology—How It Works.\u003c\/p\u003e \u003cp\u003e11.3. Standardization.\u003c\/p\u003e \u003cp\u003e11.4. Quantification.\u003c\/p\u003e \u003cp\u003e11.5. Localization.\u003c\/p\u003e \u003cp\u003e11.6. Multiparametric Analysis.\u003c\/p\u003e \u003cp\u003e11.7. Application of AQUA Technology to Drug Discovery and Companion Diagnostics.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e11.8. Summary and Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52257118585112,"sku":"9780470145593","price":113.79,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470145593.jpg?v=1781277092","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/molecular-pathology-in-drug-discovery-and-development-hardback-9780470145593","provider":"Freshly Printed Books","version":"1.0","type":"link"}