{"product_id":"molecular-cancer-therapeutics-strategies-for-drug-discovery-and-development-hardback-9780471432029","title":"Molecular Cancer Therapeutics; Strategies for Drug Discovery and Development (Hardback) 9780471432029","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eMolecular Cancer Therapeutics\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eStrategies for Drug Discovery and Development\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eGeorge C. Prendergast (Edited by), GC Prendergast (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780471432029, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 20 April 2004\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e368 pages, Photos: 4 B\u0026amp;W, 0 Color; Drawings: 34 B\u0026amp;W, 0 Color; Tables: 22 B\u0026amp;W, 0 Color\u003cbr\u003e25.8 x 18.4 x 2.2 cm, 0.83 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"…this little book represents the ever-so-important 'and' that links research and development together in a logical and thoughtful manner...a valuable resource for scientists and clinicians alike…\" (\u003ci\u003eNew England Journal of Medicine\u003c\/i\u003e, January 27, 2005)  \u003cp\u003e\"...an excellent publication.… I recommended it for libraries...those involved in cancer research...those who teach pharmacy and medical students about drugs used in the treatment of cancer.\" (\u003ci\u003eThe Annals of Pharmacotherapy\u003c\/i\u003e, December 2004)\u003c\/p\u003e \u003cp\u003e\"…provides an up-to-date overview of the different phases of drug discovery and preclinical development of experimental cancer principles.” (\u003ci\u003eDrug Discovery \u0026amp; Development\u003c\/i\u003e, September 2004)\u003c\/p\u003e \u003cp\u003e\"…a most informative book, discussing the important evolution in the field of cancer therapeutics…\" (\u003ci\u003eAmerican Journal of Therapeutics\u003c\/i\u003e, July\/August 2004)\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eMolecular Cancer Therapeutics\u003c\/i\u003e covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development.\u003cbr\u003e This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer. Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface.  \u003cp\u003eContributors.\u003c\/p\u003e \u003cp\u003eChapter 1. Introduction (G. Prendergast).\u003c\/p\u003e \u003cp\u003eChapter 2. Molecular Cancer Therapeutics: Will the Promise Be Fulfilled? (B. Teicher).\u003c\/p\u003e \u003cp\u003eChapter 3. Cancer Genetics and Drug Target Selection (G. Zhang \u0026amp; W. Kaelin).\u003c\/p\u003e \u003cp\u003eChapter 4. RNA Interference in Mammals: Journey to the Center of Human Disease (P. Paddison \u0026amp; G. Hannon).\u003c\/p\u003e \u003cp\u003eChapter 5. Applications and Issues for Tissue Arrays in Target and Drug Discovery (E. Jonasch, K. Do, C. Logothetis, \u0026amp; T. McDonnell).\u003c\/p\u003e \u003cp\u003eChapter 6. Protein Transduction Strategies for Target and Mechanism Validation (S. Ezhevsky \u0026amp; S. Dowdy).\u003c\/p\u003e \u003cp\u003eChapter 7. Drug Screening: Assay Development Issues (S. Carroll, J. Inglese, S. Mao, \u0026amp; D. Olson).\u003c\/p\u003e \u003cp\u003eChapter 8. Gene Microarray Technologies for Cancer Drug Discovery and Development (R. te Poele, P. Clarke, \u0026amp; P. Workman).\u003c\/p\u003e \u003cp\u003eChapter 9. Transgenic Mouse Models of Cancer (T. Bowen \u0026amp; A. Wynshaw-Boris).\u003c\/p\u003e \u003cp\u003eChapter 10. Transgenic versus Xenograft Mouse Models of Cancer: Utility and Issues (M. Liu, W. Bishop, Y. Wang, \u0026amp; P. Kirschmeier).\u003c\/p\u003e \u003cp\u003eChapter 11. Pharmacodynamic Assays in Cancer Drug Discovery: From Preclinical Validation to Clinical Trial Monitoring (R. Lobell, N. Kohl, \u0026amp; L. Sepp-Lorenzino).\u003c\/p\u003e \u003cp\u003eChapter 12. Pharmacokinetic and Toxicology Issues in Cancer Drug Discovery and Development (P. Benfield \u0026amp; B. Car).\u003c\/p\u003e \u003cp\u003eChapter 13. Clinical Development Issues (S. Averbuch, M. Wolf, B. El-Rayes, \u0026amp; P. LoRusso).\u003c\/p\u003e \u003cp\u003eChapter 14. Intellectual Property and Commercialization Issues in Drug Discovery (L. Malseed).\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biology, life sciences [\u003ca title=\"See our other books on Biology, life sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biology,%20life%20sciences%20%5BPS%5D%22\"\u003ePS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Liss","offers":[{"title":"Brand New","offer_id":52293476876568,"sku":"9780471432029","price":121.39,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780471432029.jpg?v=1781641230","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/molecular-cancer-therapeutics-strategies-for-drug-discovery-and-development-hardback-9780471432029","provider":"Freshly Printed Books","version":"1.0","type":"link"}