{"product_id":"modern-organic-synthesis-an-introduction-paperback-softback-9781119086536","title":"Modern Organic Synthesis; An Introduction (Paperback \/ softback) 9781119086536","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eModern Organic Synthesis\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eAn Introduction\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eGeorge S. Zweifel (Author), Michael H. Nantz (Author), Peter Somfai (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781119086536, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 26 May 2017\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e416 pages\u003cbr\u003e27.4 x 21.3 x 2.5 cm, 0.93 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eThis book bridges the gap between sophomore and advanced \/ graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment.\u003c\/p\u003e \u003cp\u003e• Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation\u003cbr\u003e• Uses a concise and easy-to-read style, with many illustrated examples\u003cbr\u003e• Updates material, examples, and references from the first edition\u003cbr\u003e• Adds coverage of organocatalysts and organometallic reagents\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eAbout the Authors ix\u003c\/p\u003e \u003cp\u003ePreface to the Second Edition xi\u003c\/p\u003e \u003cp\u003ePrefacetothefirstedition xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 SyntheticDesign 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Retrosynthetic Analysis 1\u003c\/p\u003e \u003cp\u003e1.2 Reversal of the Carbonyl Group Polarity (Umpolung) 6\u003c\/p\u003e \u003cp\u003e1.3 Steps in Planning a Synthesis 11\u003c\/p\u003e \u003cp\u003e1.4 Choice of Synthetic Method 16\u003c\/p\u003e \u003cp\u003e1.5 Domino Reactions (Cascade or Tandem Reactions) 18\u003c\/p\u003e \u003cp\u003e1.6 Computer-Assisted Retrosynthetic Analysis 19\u003c\/p\u003e \u003cp\u003eReferences 19\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Stereochemical Considerations in Planning Syntheses 21\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Conformational Analysis 21\u003c\/p\u003e \u003cp\u003e2.2 Evaluation of Non-Bonded Interactions 25\u003c\/p\u003e \u003cp\u003e2.3 Six-Membered Heterocyclic Systems 29\u003c\/p\u003e \u003cp\u003e2.4 Polycyclic Ring Systems 30\u003c\/p\u003e \u003cp\u003e2.5 Cyclohexyl Systems with sp 2 -Hybridized Atoms 33\u003c\/p\u003e \u003cp\u003e2.6 Significant Energy Difference 35\u003c\/p\u003e \u003cp\u003e2.7 Computer-Assisted Molecular Modeling 35\u003c\/p\u003e \u003cp\u003e2.8 Reactivity and Product Determination as a Function of Conformation 36\u003c\/p\u003e \u003cp\u003eReferences 42\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 The Concept of Protecting Functional Groups 45\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Protection of N–H Groups 45\u003c\/p\u003e \u003cp\u003e3.2 Protection of OH Groups 48\u003c\/p\u003e \u003cp\u003e3.3 Protection of Diols as Acetals 55\u003c\/p\u003e \u003cp\u003e3.4 Protection of Carbonyl Groups in Aldehydes and Ketones 56\u003c\/p\u003e \u003cp\u003e3.5 Protection of the Carboxyl Group 62\u003c\/p\u003e \u003cp\u003e3.6 Protection of Double Bonds 66\u003c\/p\u003e \u003cp\u003e3.7 Protection of Triple Bonds 66\u003c\/p\u003e \u003cp\u003eReferences 66\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Functional Group Transformations 71\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Oxidation of Alcohols to Aldehydes and Ketones 71\u003c\/p\u003e \u003cp\u003e4.2 Reagents and Procedures for Alcohol Oxidation 72\u003c\/p\u003e \u003cp\u003e4.3 Chemoselective Oxidizing Agents 76\u003c\/p\u003e \u003cp\u003e4.4 Oxidation of Acyloins 79\u003c\/p\u003e \u003cp\u003e4.5 Oxidation of Tertiary Allylic Alcohols 79\u003c\/p\u003e \u003cp\u003e4.6 Oxidative Procedures to Carboxylic Acids 80\u003c\/p\u003e \u003cp\u003e4.7 Allylic Oxidation of Alkenes 82\u003c\/p\u003e \u003cp\u003e4.8 Terminology for Reduction of Carbonyl Compounds 85\u003c\/p\u003e \u003cp\u003e4.9 Nucleophilic Reducing Agents 86\u003c\/p\u003e \u003cp\u003e4.10 Electrophilic Reducing Agents 91\u003c\/p\u003e \u003cp\u003e4.11 Regio- and Chemoselective Reductions 93\u003c\/p\u003e \u003cp\u003e4.12 Diastereoselective Reductions of Cyclic Ketones 97\u003c\/p\u003e \u003cp\u003e4.13 Inversion of Secondary Alcohol Stereochemistry 98\u003c\/p\u003e \u003cp\u003e4.14 Diastereofacial Selectivity in Acyclic Systems 99\u003c\/p\u003e \u003cp\u003e4.15 Enantioselective Reductions 104\u003c\/p\u003e \u003cp\u003eReferences 108\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Functional Group Transformations 115\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Reactions of Carbon–Carbon Double Bonds 115\u003c\/p\u003e \u003cp\u003e5.2 Reactions of Carbon–Carbon Triple Bonds 160\u003c\/p\u003e \u003cp\u003eReferences 167\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Formation of Carbon–Carbon Single Bonds via Enolate Anions 175\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 1,3-Dicarbonyl Compounds 175\u003c\/p\u003e \u003cp\u003e6.2 Direct Alkylation of Enolates 185\u003c\/p\u003e \u003cp\u003e6.3 Cyclization Reactions—Baldwin’s Rules for Ring Closure 193\u003c\/p\u003e \u003cp\u003e6.4 Stereochemistry of Cyclic Ketone Alkylation 195\u003c\/p\u003e \u003cp\u003e6.5 Imine and Hydrazone Anions 196\u003c\/p\u003e \u003cp\u003e6.6 Enamines 197\u003c\/p\u003e \u003cp\u003e6.7 The Aldol Reaction 199\u003c\/p\u003e \u003cp\u003e6.8 Condensation Reactions of Enols and Enolates 213\u003c\/p\u003e \u003cp\u003e6.9 Robinson Annulation 217\u003c\/p\u003e \u003cp\u003eReferences 220\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Formation of Carbon–Carbon Bonds via Organometallic Reagents 227\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Organolithium Reagents 227\u003c\/p\u003e \u003cp\u003e7.2 Organomagnesium Reagents 236\u003c\/p\u003e \u003cp\u003e7.3 Organotitanium Reagents 239\u003c\/p\u003e \u003cp\u003e7.4 Organocerium Reagents 240\u003c\/p\u003e \u003cp\u003e7.5 Organocopper Reagents 241\u003c\/p\u003e \u003cp\u003e7.6 Organochromium Reagents 251\u003c\/p\u003e \u003cp\u003e7.7 Organozinc Reagents 252\u003c\/p\u003e \u003cp\u003e7.8 Organoboron Reagents 256\u003c\/p\u003e \u003cp\u003e7.9 Organosilicon Reagents 264\u003c\/p\u003e \u003cp\u003e7.10 Organogold Chemistry 274\u003c\/p\u003e \u003cp\u003eReferences 278\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Palladium-Catalyzed Coupling Reactions 285\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Palladium Oxidation State 285\u003c\/p\u003e \u003cp\u003e8.2 Organic Synthesis with Palladium(0) Complexes 286\u003c\/p\u003e \u003cp\u003e8.3 The Heck Reaction—Palladium(0)-Catalyzed Olefin Insertion Reactions 288\u003c\/p\u003e \u003cp\u003e8.4 Palladium-Catalyzed Cross-Coupling with Organometallic Reagents 292\u003c\/p\u003e \u003cp\u003e8.5 Cross-Coupling Reactions Involving sp-Carbons 301\u003c\/p\u003e \u003cp\u003e8.6 The Trost–Tsuji Reaction 304\u003c\/p\u003e \u003cp\u003eReferences 307\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Formation of Carbon–Carbon π-Bonds 313\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Formation of Carbon–Carbon Double Bonds 313\u003c\/p\u003e \u003cp\u003e9.2 Formation of Carbon–Carbon Triple Bonds 343\u003c\/p\u003e \u003cp\u003eReferences 350\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Syntheses of Carbocyclic Systems 355\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Intramolecular Free Radical Cyclizations 355\u003c\/p\u003e \u003cp\u003e10.2 Cation–π Cyclizations 361\u003c\/p\u003e \u003cp\u003e10.3 Pericyclic Reactions 364\u003c\/p\u003e \u003cp\u003e10.4 Ring-Closing Olefin Metathesis 375\u003c\/p\u003e \u003cp\u003eReferences 378\u003c\/p\u003e \u003cp\u003eIndex 383 \u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52507274576152,"sku":"9781119086536","price":77.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781119086536.jpg?v=1786443178","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/modern-organic-synthesis-an-introduction-paperback-softback-9781119086536","provider":"Freshly Printed Books","version":"1.0","type":"link"}