{"product_id":"medicinal-natural-products-a-biosynthetic-approach-hardback-9780470741689","title":"Medicinal Natural Products; A Biosynthetic Approach (Hardback) 9780470741689","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eMedicinal Natural Products\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eA Biosynthetic Approach\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003ePaul M. Dewick (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470741689, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 6 February 2009\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e552 pages\u003cbr\u003e25.4 x 19.7 x 3.5 cm, 1.276 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"Students should be empowered for a deductive analysis of the presented substances.\" (\u003ci\u003eArzneimittelforschung\u003c\/i\u003e, December 2009)  \u003cp\u003e \"This new edition is an excellent text that is unrivaled in both its scope and overall coverage of natural products biosynthesis.\" (\u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e, August 2009)\u003c\/p\u003e  \u003cp\u003e \"There is no question that this is the best book available on the biosynthesis and bio-organic chemistry of medicinally important natural products.\" (\u003ci\u003eEducation in Chemistry\u003c\/i\u003e, September 2009)\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eMedicinal Natural Products: A Biosynthetic Approach, Third Edition\u003c\/i\u003e, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine. \u003cp\u003eThere have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. \u003ci\u003eMedicinal Natural Products\u003c\/i\u003e has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ea comprehensive treatment of plant, microbial, and animal natural products in one volume\u003c\/li\u003e \u003cli\u003eextensive use of chemical schemes with annotated mechanistic explanations\u003c\/li\u003e \u003cli\u003ecross-referencing to emphasize links and similarities\u003c\/li\u003e \u003cli\u003eboxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eMedicinal Natural Products: A Biosynthetic Approach, Third Edition,\u003c\/i\u003e is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003e1 About this book, and how to use it 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe subject 1\u003c\/p\u003e \u003cp\u003eThe aim 1\u003c\/p\u003e \u003cp\u003eThe approach 2\u003c\/p\u003e \u003cp\u003eThe topics 2\u003c\/p\u003e \u003cp\u003eThe figures 2\u003c\/p\u003e \u003cp\u003eFurther reading 3\u003c\/p\u003e \u003cp\u003eWhat to study 3\u003c\/p\u003e \u003cp\u003eWhat to learn 3\u003c\/p\u003e \u003cp\u003eNomenclature 3\u003c\/p\u003e \u003cp\u003eConventions regarding acids, bases, and ions 4\u003c\/p\u003e \u003cp\u003eSome common abbreviations 4\u003c\/p\u003e \u003cp\u003eFurther reading 5\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Secondary metabolism: the building blocks and construction mechanisms 7\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePrimary and secondary metabolism 7\u003c\/p\u003e \u003cp\u003eThe building blocks 8\u003c\/p\u003e \u003cp\u003eThe construction mechanisms 11\u003c\/p\u003e \u003cp\u003eAlkylation reactions: nucleophilic substitution 12\u003c\/p\u003e \u003cp\u003eAlkylation reactions: electrophilic addition 12\u003c\/p\u003e \u003cp\u003eWagner–Meerwein rearrangements 15\u003c\/p\u003e \u003cp\u003eAldol and Claisen reactions 15\u003c\/p\u003e \u003cp\u003eImine formation and the Mannich reaction 18\u003c\/p\u003e \u003cp\u003eAmino acids and transamination 20\u003c\/p\u003e \u003cp\u003eDecarboxylation reactions 22\u003c\/p\u003e \u003cp\u003eOxidation and reduction reactions 24\u003c\/p\u003e \u003cp\u003eDehydrogenases 24\u003c\/p\u003e \u003cp\u003eOxidases 26\u003c\/p\u003e \u003cp\u003eMonooxygenases 26\u003c\/p\u003e \u003cp\u003eDioxygenases 26\u003c\/p\u003e \u003cp\u003eAmine oxidases 27\u003c\/p\u003e \u003cp\u003eBaeyer–Villiger monooxygenases 27\u003c\/p\u003e \u003cp\u003ePhenolic oxidative coupling 28\u003c\/p\u003e \u003cp\u003eHalogenation reactions 28\u003c\/p\u003e \u003cp\u003eGlycosylation reactions 31\u003c\/p\u003e \u003cp\u003eElucidating biosynthetic pathways 34\u003c\/p\u003e \u003cp\u003eFurther reading 38\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 The acetate pathway: fatty acids and polyketides 39\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eFatty acid synthase: saturated fatty acids 39\u003c\/p\u003e \u003cp\u003eUnsaturated fatty acids 44\u003c\/p\u003e \u003cp\u003eUncommon fatty acids 53\u003c\/p\u003e \u003cp\u003eProstaglandins 58\u003c\/p\u003e \u003cp\u003eThromboxanes 64\u003c\/p\u003e \u003cp\u003eLeukotrienes 64\u003c\/p\u003e \u003cp\u003ePolyketide synthases: generalities 66\u003c\/p\u003e \u003cp\u003ePolyketide synthases: macrolides 68\u003c\/p\u003e \u003cp\u003ePolyketide synthases: linear polyketides and polyethers 90\u003c\/p\u003e \u003cp\u003eDiels–Alder cyclizations 96\u003c\/p\u003e \u003cp\u003ePolyketide synthases: aromatics 96\u003c\/p\u003e \u003cp\u003eCyclizations 99\u003c\/p\u003e \u003cp\u003ePost-polyketide synthase modifications 103\u003c\/p\u003e \u003cp\u003eStarter groups 116\u003c\/p\u003e \u003cp\u003eFurther reading 131\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 The shikimate pathway: aromatic amino acids and phenylpropanoids 137\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAromatic amino acids and simple benzoic acids 137\u003c\/p\u003e \u003cp\u003ePhenylpropanoids 148\u003c\/p\u003e \u003cp\u003eCinnamic acids and esters 148\u003c\/p\u003e \u003cp\u003eLignans and lignin 152\u003c\/p\u003e \u003cp\u003ePhenylpropenes 156\u003c\/p\u003e \u003cp\u003eBenzoic acids from C 6 C 3 compounds 157\u003c\/p\u003e \u003cp\u003eCoumarins 161\u003c\/p\u003e \u003cp\u003eAromatic polyketides 166\u003c\/p\u003e \u003cp\u003eStyrylpyrones, diarylheptanoids 166\u003c\/p\u003e \u003cp\u003eFlavonoids and stilbenes 167\u003c\/p\u003e \u003cp\u003eFlavonolignans 173\u003c\/p\u003e \u003cp\u003eIsoflavonoids 174\u003c\/p\u003e \u003cp\u003eTerpenoid quinones 178\u003c\/p\u003e \u003cp\u003eFurther reading 184\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 The mevalonate and methylerythritol phosphate pathways: terpenoids and steroids 187\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMevalonic acid and methylerythritol phosphate 188\u003c\/p\u003e \u003cp\u003eHemiterpenes (C 5) 192\u003c\/p\u003e \u003cp\u003eMonoterpenes (C 10) 193\u003c\/p\u003e \u003cp\u003eIrregular monoterpenes 204\u003c\/p\u003e \u003cp\u003eIridoids (C 10) 206\u003c\/p\u003e \u003cp\u003eSesquiterpenes (C 15) 210\u003c\/p\u003e \u003cp\u003eDiterpenes (C 20) 223\u003c\/p\u003e \u003cp\u003eSesterterpenes (C 25) 234\u003c\/p\u003e \u003cp\u003eTriterpenes (C 30) 234\u003c\/p\u003e \u003cp\u003eTriterpenoid saponins 242\u003c\/p\u003e \u003cp\u003eSteroids 247\u003c\/p\u003e \u003cp\u003eStereochemistry and nomenclature 247\u003c\/p\u003e \u003cp\u003eCholesterol 248\u003c\/p\u003e \u003cp\u003ePhytosterols 251\u003c\/p\u003e \u003cp\u003eVitamin d 256\u003c\/p\u003e \u003cp\u003eSteroidal saponins 259\u003c\/p\u003e \u003cp\u003eCardioactive glycosides 265\u003c\/p\u003e \u003cp\u003eBile acids 275\u003c\/p\u003e \u003cp\u003eAdrenocortical hormones\/corticosteroids 277\u003c\/p\u003e \u003cp\u003eSemi-synthesis of corticosteroids 277\u003c\/p\u003e \u003cp\u003eProgestogens 287\u003c\/p\u003e \u003cp\u003eOestrogens 290\u003c\/p\u003e \u003cp\u003eAndrogens 296\u003c\/p\u003e \u003cp\u003eTetraterpenes (C 40) 298\u003c\/p\u003e \u003cp\u003eHigher terpenoids 306\u003c\/p\u003e \u003cp\u003eFurther reading 306\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Alkaloids 311\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAlkaloids derived from ornithine 311\u003c\/p\u003e \u003cp\u003ePolyamines 311\u003c\/p\u003e \u003cp\u003ePyrrolidine and tropane alkaloids 312\u003c\/p\u003e \u003cp\u003ePyrrolizidine alkaloids 324\u003c\/p\u003e \u003cp\u003eAlkaloids derived from lysine 326\u003c\/p\u003e \u003cp\u003ePiperidine alkaloids 326\u003c\/p\u003e \u003cp\u003eQuinolizidine alkaloids 328\u003c\/p\u003e \u003cp\u003eIndolizidine alkaloids 330\u003c\/p\u003e \u003cp\u003eAlkaloids derived from nicotinic acid 331\u003c\/p\u003e \u003cp\u003ePyridine alkaloids 331\u003c\/p\u003e \u003cp\u003eAlkaloids derived from tyrosine 336\u003c\/p\u003e \u003cp\u003ePhenylethylamines and simple tetrahydroisoquinoline alkaloids 336\u003c\/p\u003e \u003cp\u003eModified benzyltetrahydroisoquinoline alkaloids 346\u003c\/p\u003e \u003cp\u003ePhenethylisoquinoline alkaloids 359\u003c\/p\u003e \u003cp\u003eTerpenoid tetrahydroisoquinoline alkaloids 363\u003c\/p\u003e \u003cp\u003eAmaryllidaceae alkaloids 365\u003c\/p\u003e \u003cp\u003eAlkaloids derived from tryptophan 366\u003c\/p\u003e \u003cp\u003eSimple indole alkaloids 366\u003c\/p\u003e \u003cp\u003eSimple β-carboline alkaloids 369\u003c\/p\u003e \u003cp\u003eTerpenoid indole alkaloids 369\u003c\/p\u003e \u003cp\u003eQuinoline alkaloids 380\u003c\/p\u003e \u003cp\u003ePyrroloindole alkaloids 385\u003c\/p\u003e \u003cp\u003eErgot alkaloids 387\u003c\/p\u003e \u003cp\u003eAlkaloids derived from anthranilic acid 395\u003c\/p\u003e \u003cp\u003eQuinazoline alkaloids 395\u003c\/p\u003e \u003cp\u003eQuinoline and acridine alkaloids 396\u003c\/p\u003e \u003cp\u003eAlkaloids derived from histidine 398\u003c\/p\u003e \u003cp\u003eImidazole alkaloids 398\u003c\/p\u003e \u003cp\u003eAlkaloids derived by amination reactions 400\u003c\/p\u003e \u003cp\u003eAcetate-derived alkaloids 401\u003c\/p\u003e \u003cp\u003ePhenylalanine-derived alkaloids 401\u003c\/p\u003e \u003cp\u003eTerpenoid alkaloids 406\u003c\/p\u003e \u003cp\u003eSteroidal alkaloids 406\u003c\/p\u003e \u003cp\u003ePurine alkaloids 413\u003c\/p\u003e \u003cp\u003eCaffeine 413\u003c\/p\u003e \u003cp\u003eSaxitoxin and tetrodotoxin 416\u003c\/p\u003e \u003cp\u003eFurther reading 417\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Peptides, proteins, and other amino acid derivatives 421\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePeptides and proteins 421\u003c\/p\u003e \u003cp\u003eRibosomal peptide biosynthesis 422\u003c\/p\u003e \u003cp\u003ePeptide hormones 426\u003c\/p\u003e \u003cp\u003eThyroid hormones 426\u003c\/p\u003e \u003cp\u003eHypothalamic hormones 427\u003c\/p\u003e \u003cp\u003eAnterior pituitary hormones 429\u003c\/p\u003e \u003cp\u003ePosterior pituitary hormones 430\u003c\/p\u003e \u003cp\u003ePancreatic hormones 432\u003c\/p\u003e \u003cp\u003eInterferons 433\u003c\/p\u003e \u003cp\u003eOpioid peptides 434\u003c\/p\u003e \u003cp\u003eRibosomal peptide toxins 434\u003c\/p\u003e \u003cp\u003eEnzymes 438\u003c\/p\u003e \u003cp\u003eNon-ribosomal peptide biosynthesis 438\u003c\/p\u003e \u003cp\u003eModified peptides: penicillins, cephalosporins, and other β-lactams 458\u003c\/p\u003e \u003cp\u003ePenicillins 458\u003c\/p\u003e \u003cp\u003eCephalosporins 465\u003c\/p\u003e \u003cp\u003eOther β-lactams 469\u003c\/p\u003e \u003cp\u003eCyanogenic glycosides 476\u003c\/p\u003e \u003cp\u003eGlucosinolates 477\u003c\/p\u003e \u003cp\u003eCysteine sulfoxides 480\u003c\/p\u003e \u003cp\u003eFurther reading 481\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Carbohydrates 485\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMonosaccharides 485\u003c\/p\u003e \u003cp\u003eOligosaccharides 490\u003c\/p\u003e \u003cp\u003ePolysaccharides 493\u003c\/p\u003e \u003cp\u003eAminosugars and aminoglycosides 498\u003c\/p\u003e \u003cp\u003eFurther reading 507\u003c\/p\u003e \u003cp\u003eIndex 509\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand 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