{"product_id":"medicinal-chemistry-fundamentals-hardback-9781785482885","title":"Medicinal Chemistry; Fundamentals (Hardback) 9781785482885","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eMedicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eFundamentals\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eDescribes the fundamental concepts of Medicinal Chemistry, including physico-chemical properties (pKa, lipophilicity, solubility, polar surface), pharmacophore, Lipinsky parameters, and prodrugs\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eRoland Barret (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781785482885, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 3 July 2018\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e172 pages\u003cbr\u003e22.9 x 15.1 x 1.9 cm, 0.4 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eMedicinal Chemistry: Fundaments\u003c\/i\u003e presents the cycle of the life of drugs, their physico-chemical properties, and consequences that arise in development. The fundamental concepts of Medicinal Chemistry (pharmacophore, prodrugs, Lipinsky rules) are also presented, including discussions on specific concerns of the European Pharmacopeia – the industrialist’s bible – its role, and a description of the monographs of active principles.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e1. Medicines and Drugs 2. Importance and Evaluation of the pKa 3. Importance and Evaluation of Lipophilicity 4. Importance and Evaluation of Solubility 5. Importance and Evaluation of the Polar Surface Area (PSA and TPSA) 6. Lipinski’s Rule of Five 7. Principle of a Prodrug 8. Pharmacophore 9. The European Pharmacopoeia\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"ISTE Press - Elsevier","offers":[{"title":"Default Title","offer_id":46651737407768,"sku":"9781785482885","price":87.79,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9781785482885_1f692c8a-c3e8-4b33-a653-31542fcc1249.jpg?v=1696694815","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/medicinal-chemistry-fundamentals-hardback-9781785482885","provider":"Freshly Printed Books","version":"1.0","type":"link"}