{"product_id":"medicinal-chemistry-for-practitioners-hardback-9781119607281","title":"Medicinal Chemistry for Practitioners (Hardback) 9781119607281","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eMedicinal Chemistry for Practitioners\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eJie Jack Li (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781119607281, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 3 July 2020\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e416 pages\u003cbr\u003e1 x 1 x 1 cm, 0.454 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"The book collects an important amount of data that are presented clearly and in depth, with the support of numerous schemes and figures, making reading very fluent.\" -- ChemMedChem, Jan 2022\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003ePresenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1. Drug Targets 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Selection and Validation of Drug Targets 1\u003c\/p\u003e \u003cp\u003e1.1.1 Factors to Consider 1\u003c\/p\u003e \u003cp\u003e1.1.2 Target Selection 5\u003c\/p\u003e \u003cp\u003e1.1.3 Target Validation 6\u003c\/p\u003e \u003cp\u003e1.2 Enzymes 8\u003c\/p\u003e \u003cp\u003e1.2.1 Competitive Inhibitor 8\u003c\/p\u003e \u003cp\u003e1.2.2 Allosteric Inhibitors 21\u003c\/p\u003e \u003cp\u003e1.2.3 Covalent Irreversible Inhibitors 28\u003c\/p\u003e \u003cp\u003e1.2.4 Transition-state Mimetics 37\u003c\/p\u003e \u003cp\u003e1.2.5 Suicide Substrates 42\u003c\/p\u003e \u003cp\u003e1.2.6 Isozyme Selectivity of Inhibitors 45\u003c\/p\u003e \u003cp\u003e1.3 Receptors 52\u003c\/p\u003e \u003cp\u003e1.3.1 G-Protein-Coupled Receptors 58\u003c\/p\u003e \u003cp\u003e1.3.2 Nuclear Hormone Receptors 72\u003c\/p\u003e \u003cp\u003e1.3.3 Growth Factor Receptors 79\u003c\/p\u003e \u003cp\u003e1.3.4 Ionotropic Receptors 80\u003c\/p\u003e \u003cp\u003e1.4 Ion Channels 81\u003c\/p\u003e \u003cp\u003e1.4.1 Calcium Channel Blockers 81\u003c\/p\u003e \u003cp\u003e1.4.2 Sodium Channel Blockers 83\u003c\/p\u003e \u003cp\u003e1.4.3 Potassium Channel Blockers 83\u003c\/p\u003e \u003cp\u003e1.5 Carrier Proteins 84\u003c\/p\u003e \u003cp\u003e1.6 Structural Proteins 85\u003c\/p\u003e \u003cp\u003e1.7 Nucleic Acids 85\u003c\/p\u003e \u003cp\u003e1.8 Protein-protein Interactions 87\u003c\/p\u003e \u003cp\u003e1.9 Further Readings 89\u003c\/p\u003e \u003cp\u003e1.10 References 89\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2 Hit\/Lead Discovery 97\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Irrational Drug Design (Serendipity) 97\u003c\/p\u003e \u003cp\u003e2.2 Natural Products 98\u003c\/p\u003e \u003cp\u003e2.2.1 From Plants 98\u003c\/p\u003e \u003cp\u003e2.2.2 From Animals 101\u003c\/p\u003e \u003cp\u003e2.2.3 From Microorganisms 104\u003c\/p\u003e \u003cp\u003e2.2.4 From Natural Ligands 105\u003c\/p\u003e \u003cp\u003e2.2.5 From Modifying Existing Drugs 106\u003c\/p\u003e \u003cp\u003e2.3 High Through-put Screening (HTS) 107\u003c\/p\u003e \u003cp\u003e2.4 Fragment-based Lead Discovery 111\u003c\/p\u003e \u003cp\u003e2.5 DNA-encoded Library (DEL) 116\u003c\/p\u003e \u003cp\u003e2.6 PROTAC 118\u003c\/p\u003e \u003cp\u003e2.7 Further Readings 128\u003c\/p\u003e \u003cp\u003e2.8 References 128\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3. Pharmacokinetics (ADME) 133\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Physicochemical Properties 133\u003c\/p\u003e \u003cp\u003e3.1.1 Lipophilicity 133\u003c\/p\u003e \u003cp\u003e3.1.2 Hydrogen Bonding 138\u003c\/p\u003e \u003cp\u003e3.1.3. Polar Surface Area 141\u003c\/p\u003e \u003cp\u003e3.1.4 Rotatable Bonds 142\u003c\/p\u003e \u003cp\u003e3.1.5 Rule of 5 143\u003c\/p\u003e \u003cp\u003e3.1.6 Ligand Efficiency 144\u003c\/p\u003e \u003cp\u003e3.1.7 Lipophilic Efficiency 145\u003c\/p\u003e \u003cp\u003e3.2 Absorption 146\u003c\/p\u003e \u003cp\u003e3.2.1 Definition of Pharmacokinetics Parameters 146\u003c\/p\u003e \u003cp\u003e3.2.2 Improving Solubility 150\u003c\/p\u003e \u003cp\u003e3.2.3 Absorption by Diffusion 156\u003c\/p\u003e \u003cp\u003e3.2.4 Absorption by Active Transports 157\u003c\/p\u003e \u003cp\u003e3.2.5 Absorption by Pinocytosis 163\u003c\/p\u003e \u003cp\u003e3.3 Distribution 164\u003c\/p\u003e \u003cp\u003e3.3.1. Around the Blood Supply, to Tissues, and to Cells 164\u003c\/p\u003e \u003cp\u003e3.3.2. Blood–Brain Barrier 167\u003c\/p\u003e \u003cp\u003e3.3.3. Efflux Transporters 170\u003c\/p\u003e \u003cp\u003e3.3.4. Plasma Protein Binding 175\u003c\/p\u003e \u003cp\u003e3.4 Metabolism 179\u003c\/p\u003e \u003cp\u003e3.4.1. Overview of Drug Metabolism 179\u003c\/p\u003e \u003cp\u003e3.4.2 Cytochrome P450 Enzymes 182\u003c\/p\u003e \u003cp\u003e3.4.3. Drug–Drug Interactions 183\u003c\/p\u003e \u003cp\u003e3.4.4. Phase I Metabolism 186\u003c\/p\u003e \u003cp\u003e3.4.5. Phase II Metabolism 198\u003c\/p\u003e \u003cp\u003e3.5 Excretion 205\u003c\/p\u003e \u003cp\u003e3.5.1. Renal Excretion 206\u003c\/p\u003e \u003cp\u003e3.5.2. Non-Renal Excretion 207\u003c\/p\u003e \u003cp\u003e3.6 Pro-drugs 209\u003c\/p\u003e \u003cp\u003e3.6.1. Overcoming Formulation and Administration Problems 209\u003c\/p\u003e \u003cp\u003e3.6.2. Overcoming Absorption Barriers 211\u003c\/p\u003e \u003cp\u003e3.6.3. Overcoming Distribution Problems 214\u003c\/p\u003e \u003cp\u003e3.6.4. Overcoming Metabolism and Excretion Problems 214\u003c\/p\u003e \u003cp\u003e3.6.5. Overcoming Toxicity Problems 215\u003c\/p\u003e \u003cp\u003e3.7 Further Readings 218\u003c\/p\u003e \u003cp\u003e3.8 References 218\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4 Bioisosteres 225\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction to Bioisosteres 225\u003c\/p\u003e \u003cp\u003e4.1.1 Definition 225\u003c\/p\u003e \u003cp\u003e4.1.2 Utility 225\u003c\/p\u003e \u003cp\u003e4.2 Hydrogen Isosteres 232\u003c\/p\u003e \u003cp\u003e4.2.1 Deuterium 232\u003c\/p\u003e \u003cp\u003e4.2.2. Fluorine 235\u003c\/p\u003e \u003cp\u003e4.2.3. Chlorine 239\u003c\/p\u003e \u003cp\u003e4.2.4. Methyl 241\u003c\/p\u003e \u003cp\u003e4.2 Alkyl Isosteres 243\u003c\/p\u003e \u003cp\u003e4.3.1 O for CH2 244\u003c\/p\u003e \u003cp\u003e4.3.2 Cyclopropane as an Alkyl Isostere 244\u003c\/p\u003e \u003cp\u003e4.3.3 Silicon as an Isostere of Carbon 246\u003c\/p\u003e \u003cp\u003e4.3.4 t-Butyl Isosteres 247\u003c\/p\u003e \u003cp\u003e4.4 Alcohol, Phenol, and Thiol Isosteres 250\u003c\/p\u003e \u003cp\u003e4.4.1 Alcohol 250\u003c\/p\u003e \u003cp\u003e4.4.2 Phenol 253\u003c\/p\u003e \u003cp\u003e4.4.3. Thiol 257\u003c\/p\u003e \u003cp\u003e4.5 Carboxylic Acid and Derivative Isosteres 258\u003c\/p\u003e \u003cp\u003e4.5.1 Carboxylic Acid 258\u003c\/p\u003e \u003cp\u003e4.5.2 Hydroxamic Acid 270\u003c\/p\u003e \u003cp\u003e4.5.3 Ester and Amide 273\u003c\/p\u003e \u003cp\u003e4.5.4 Urea, Guanidine, and Amidine 279\u003c\/p\u003e \u003cp\u003e4.6 Scaffold Hopping 282\u003c\/p\u003e \u003cp\u003e4.6.1. Phenyl 282\u003c\/p\u003e \u003cp\u003e5.6.2 Biphenyl 285\u003c\/p\u003e \u003cp\u003e5.6.3 N for CH in Aromatic Rings 286\u003c\/p\u003e \u003cp\u003e5.6.4 Isosterism between Heterocycles 290\u003c\/p\u003e \u003cp\u003e4.7 Peptide Isosteres 293\u003c\/p\u003e \u003cp\u003e4.7.1 Cyclization 294\u003c\/p\u003e \u003cp\u003e4.7.2. Intramolecular Hydrogen Bonding 295\u003c\/p\u003e \u003cp\u003e4.7.3. N-Methylation 296\u003c\/p\u003e \u003cp\u003e4.7.4 Shielding 297\u003c\/p\u003e \u003cp\u003e4.8 Further Readings 298\u003c\/p\u003e \u003cp\u003e4.9 References 298\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5. Structural Alerts for Toxicity 307\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Reactive Electrophiles 307\u003c\/p\u003e \u003cp\u003e5.1.1. Alkylating Agents 308\u003c\/p\u003e \u003cp\u003e5.1.2. Michael Acceptors 312\u003c\/p\u003e \u003cp\u003e5.1.3. Heteroaromatic Halides 315\u003c\/p\u003e \u003cp\u003e5.1.4 Miscellaneous Reactive Electrophiles 317\u003c\/p\u003e \u003cp\u003e5.2 DNA Intercalators 318\u003c\/p\u003e \u003cp\u003e5.3 Carcinogens 319\u003c\/p\u003e \u003cp\u003e5.4 Metabolism Problematic Molecules 321\u003c\/p\u003e \u003cp\u003e5.4.1 Anilines and Anilides 321\u003c\/p\u003e \u003cp\u003e5.4.2 Problematic Amines 330\u003c\/p\u003e \u003cp\u003e5.4.3 Nitroaromatics 336\u003c\/p\u003e \u003cp\u003e5.4.4 Quinones and Phenols 340\u003c\/p\u003e \u003cp\u003e5.4.5 S-Containing Compounds 345\u003c\/p\u003e \u003cp\u003e5.4.6 Hydrazines and Hydrazides 350\u003c\/p\u003e \u003cp\u003e5.4.7 Methylenedioxyphenyl Moiety 355\u003c\/p\u003e \u003cp\u003e5.4.8 Electron-rich Heteroaromatics 360\u003c\/p\u003e \u003cp\u003e5.5 PAINS 368\u003c\/p\u003e \u003cp\u003e5.5.1 Unsaturated Rhodanines 368\u003c\/p\u003e \u003cp\u003e5.5.2 Phenolic Mannich Bases 371\u003c\/p\u003e \u003cp\u003e5.5.3 Invalid Metabolic Panaceas 373\u003c\/p\u003e \u003cp\u003e5.5.4 Alkylidene Barbituates etc. 373\u003c\/p\u003e \u003cp\u003e5.6 Conclusions 375\u003c\/p\u003e \u003cp\u003e5.7 Further Readings 375\u003c\/p\u003e \u003cp\u003e5.8 References 376\u003c\/p\u003e \u003cp\u003eIndex 383\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52428635308312,"sku":"9781119607281","price":103.19,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781119607281.jpg?v=1784682586","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/medicinal-chemistry-for-practitioners-hardback-9781119607281","provider":"Freshly Printed Books","version":"1.0","type":"link"}