{"product_id":"mass-spectrometry-for-drug-discovery-and-drug-development-hardback-9780470942383","title":"Mass Spectrometry for Drug Discovery and Drug Development (Hardback) 9780470942383","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eMass Spectrometry for Drug Discovery and Drug Development\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eWalter A. Korfmacher (Edited by), W Korfmacher (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470942383, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 12 March 2013\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e480 pages\u003cbr\u003e26 x 18.7 x 3.2 cm, 1.016 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eFacilitates the discovery and development of new, effective therapeutics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eWith coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMass Spectrometry for Drug Discovery and Drug Development\u003c\/i\u003e begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eHPLC–high-resolution mass spectrometry for quantitative assays\u003c\/li\u003e \u003cli\u003eMass spectrometry for siRNA\u003c\/li\u003e \u003cli\u003eQuantitative analysis of peptides\u003c\/li\u003e \u003cli\u003eMass spectrometry analysis of biological drugs\u003c\/li\u003e \u003cli\u003eApplications that support medicinal chemistry investigations\u003c\/li\u003e \u003cli\u003eMass spectrometry imaging and profiling\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThroughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMass Spectrometry for Drug Discovery and Drug Development\u003c\/i\u003e is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003e1 Overview of the Various Types of Mass Spectrometers that are Used in Drug Discovery and Drug Development 1\u003cbr\u003e \u003ci\u003eGérard Hopfgartner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Utility of High-Resolution Mass Spectrometry for New Drug Discovery Applications 37\u003cbr\u003e \u003ci\u003eWilliam Bart Emary and Nanyan Rena Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Quantitative Mass Spectrometry Considerations in a Regulated Environment 55\u003cbr\u003e \u003ci\u003eMohammed Jemal and Yuan-Qing Xia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Mass Spectrometry for Quantitative In Vitro ADME Assays 97\u003cbr\u003e \u003ci\u003eJun Zhang and Wilson Z. Shou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Metabolite Identification Using Mass Spectrometry in Drug Development 115\u003cbr\u003e \u003ci\u003eNatalia Penner, Joanna Zgoda-Pols, and Chandra Prakash\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 MS Analysis of Biological Drugs, Proteins, and Peptides 149\u003cbr\u003e \u003ci\u003eYi Du, John Mehl, and Pavlo Pristatsky\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics 191\u003cbr\u003e \u003ci\u003eHui Wei, Guodong Chen, and Adrienne A. Tymiak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Liquid Extraction Surface Analysis (LESA): A New Mass Spectrometry-Based Technique for Ambient Surface Profiling 221\u003cbr\u003e \u003ci\u003eDaniel Eikel and Jack D. Henion\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 MS Applications in Support of Medicinal Chemistry Sciences 239\u003cbr\u003e \u003ci\u003eMaarten Honing, Benno Ingelse, and Birendra N. Pramanik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Imaging Mass Spectrometry of Proteins and Peptides 277\u003cbr\u003e \u003ci\u003eMichelle L. Reyzer and Richard M. Caprioli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Imaging Mass Spectrometry for Drugs and Metabolites 303\u003cbr\u003e \u003ci\u003eStacey R. Oppenheimer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Screening Reactive Metabolites: Role of Liquid Chromatography–High-Resolution Mass Spectrometry in Combination with “Intelligent” Data Mining Tools 339\u003cbr\u003e \u003ci\u003eShuguang Ma and Swapan K. Chowdhury\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Mass Spectrometry of siRNA 357\u003cbr\u003e \u003ci\u003eMark T. Cancilla and W. Michael Flanagan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Mass Spectrometry for Metabolomics 387\u003cbr\u003e \u003ci\u003ePetia Shipkova and Michael D. Reily\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High-Resolution Full Scan? 403\u003cbr\u003e \u003ci\u003eLieve Dillen and Filip Cuyckens\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 427\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52278119334168,"sku":"9780470942383","price":82.89,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470942383.jpg?v=1781458434","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/mass-spectrometry-for-drug-discovery-and-drug-development-hardback-9780470942383","provider":"Freshly Printed Books","version":"1.0","type":"link"}