{"product_id":"macrolide-antibiotics-chemistry-biology-and-practice-hardback-9780125264518","title":"Macrolide Antibiotics; Chemistry, Biology, and Practice (Hardback) 9780125264518","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eMacrolide Antibiotics\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eChemistry, Biology, and Practice\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eSatoshi Omura (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780125264518\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 12 July 2002\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e635 pages\u003cbr\u003e22.9 x 15.2 x 3.5 cm, 1.01 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"...will be of use to students, clinicians, applied and basic scientists, and physicians. Scientists devoted to the study of secondary metabolites will especially welcome this new coverage of an important group of compounds by a leader in the field.\"\u003cb\u003e --(2003)\u003c\/b\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eMacrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition\u003c\/i\u003e explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic\/antifungal research and treament.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eContributors\u003cbr\u003ePreface\u003cbr\u003e1. Discovery of New Macrolides\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Macrolides from Actinomycetes\u003cbr\u003e     III. Macrolides from Bacteria Including Myxobacteria\u003cbr\u003e     IV. Macrolides from Fungi\u003cbr\u003e     V. Macrolides from Plants and Lichens\u003cbr\u003e     VI. Macrolides from Insects\u003cbr\u003e     VII. Other Macrolides\u003cbr\u003e     VIII. Concluding Remarks\u003cbr\u003e     References\u003cbr\u003e2. Discovery of New Macrolides from Marine Organisms\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Macrocyclic Lactones of Marine Organism Origin\u003cbr\u003e     III. Concluding Remarks\u003cbr\u003e     References\u003cbr\u003e3. Chemical Modification of Macrolides\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Fourteen-Membered Macrolides\u003cbr\u003e     III. Sixteen-Membered Macrolide Antibiotics and the Avermectin Family\u003cbr\u003e     IV. Concluding Remarks\u003cbr\u003e     References\u003cbr\u003e4. Total Synthesis of Macrolides\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Synthetic Strategy for Macrolide Synthesis\u003cbr\u003e     III. Total Synthesis of Selected Macrolides\u003cbr\u003e     IV. Concluding Remarks\u003cbr\u003e     References\u003cbr\u003e5. Biosynthesis, Regulation, and Genetics of Macrolide Production\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Reaction Mechanism of Polyketide Biosynthesis\u003cbr\u003e     III. Polyketide Synthase\u003cbr\u003e     IV. Genes Encoding Modular Polyketide Synthase\u003cbr\u003e     V. Sugar Biosynthesis\u003cbr\u003e     VI. Genetic Manipulation of PKS Genes\u003cbr\u003e     References\u003cbr\u003e6. Pharmacokinetics and Metabolism of Macrolides\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Pharmacokinetics and Metabolism\u003cbr\u003e     III. Drug Interaction\u003cbr\u003e     IV. Concluding Remarks\u003cbr\u003e     References\u003cbr\u003e7. Antimicrobial Macrolides in Clinical Practice\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Fourteen- and Fifteen-Membered Macrolides\u003cbr\u003e     III. Sixteen-Membered Macrolides\u003cbr\u003e     IV. Concluding Remarks\u003cbr\u003e     References\u003cbr\u003e8. Ivermectin in Clinical Practice\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Novel Activity of Ivermectin in Clinical Practice\u003cbr\u003e     III. Concluding Remarks\u003cbr\u003e     References\u003cbr\u003e9. Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Tacrolimus, a Brief Developmental History\u003cbr\u003e     III. Novel Activity of Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice\u003cbr\u003e     IV. Concluding Remarks\u003cbr\u003e     References\u003cbr\u003e10. Mode of Action and Resistance Mechanisms of Antimicrobial Macrolides\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Mode of Action of Macrolide Antibiotics\u003cbr\u003e     III. Mechanisms of Resistance to Antimicrobial Macrolides\u003cbr\u003e     IV. Important Developments in Macrolide Antibiotics\u003cbr\u003e     V. Concluding Remarks\u003cbr\u003e     VI. Addendum\u003cbr\u003e     References\u003cbr\u003e11. Mode of Action of Macrolides with Motilin Agonistic Activity--Motilides\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Mode of Action of Motilin\u003cbr\u003e     III. Invention of Motilides\u003cbr\u003e     IV. BiologicalActivity of Motilides\u003cbr\u003e     V. Clinical Trials of Motilides\u003cbr\u003e     VI. Concluding Remarks\u003cbr\u003e     References\u003cbr\u003e12. Novel Activity of Erythromycin and Its Derivatives\u003cbr\u003e     I. Erythromycin Treatment in Diffuse Panbronchiolitis\u003cbr\u003e     II. Inhibition of Chloride Channel\u003cbr\u003e     III. Effects of Macrolides on Cytokine\/Chemokine Expression\u003cbr\u003e     IV. Modulation of Bacterial Function\u003cbr\u003e     V. New Challenge for Novel Action\u003cbr\u003e     References\u003cbr\u003e13. Mode of Action of Avermectin\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Target of Avermectin Action\u003cbr\u003e     III. Cloning and Structure of Avermectin Binding Protein\u003cbr\u003e     IV. Concluding Remarks\u003cbr\u003e     References\u003cbr\u003e14. Mode of Action of FK506 and Rapamycin\u003cbr\u003e     I. Introduction\u003cbr\u003e     II. Initial Cellular Target for FK506 and Rapamycin; Peptidyl Prolylcis-trans Isomerases (Rotamases, Immunophilins)\u003cbr\u003e     III. Target of FK506-FKBP12 Complex: Calcineurin\u003cbr\u003e     IV. Target of Rapamycin-FKBP12 Complex: mTOR\/FRAP\/RFAT\u003cbr\u003e     V. Intervention of Intracellular Signaling Pathways by FK506 and Rapamycin\u003cbr\u003e     References\u003cbr\u003eIndex\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Bacteriology [\u003ca title=\"See our other books on Bacteriology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Bacteriology%20%5Bnon-medical%5D%20%5BPSGD%5D%22\"\u003enon-medical PSGD\u003c\/a\u003e], Microbiology [\u003ca title=\"See our other books on Microbiology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Microbiology%20%5Bnon-medical%5D%20%5BPSG%5D%22\"\u003enon-medical PSG\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649424183576,"sku":"9780125264518","price":100.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780125264518.jpg?v=1694100903","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/macrolide-antibiotics-chemistry-biology-and-practice-hardback-9780125264518","provider":"Freshly Printed Books","version":"1.0","type":"link"}