{"product_id":"lysophospholipid-receptors-signaling-and-biochemistry-hardback-9780470569054","title":"Lysophospholipid Receptors; Signaling and Biochemistry (Hardback) 9780470569054","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eLysophospholipid Receptors\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eSignaling and Biochemistry\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eJerold Chun (Edited by), J Chun (Author), Timothy Hla (Associate editor), Sarah Spiegel (Associate editor), Wouter Moolenaar (Associate editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470569054, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 10 May 2013\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e812 pages\u003cbr\u003e24.1 x 16.5 x 4.4 cm, 1.306 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eThe current state of the science supporting new research in lysophospholipids\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports—ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems—have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eLysophospholipid Receptors\u003c\/i\u003e is divided into three sections:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eReceptors and other possible effectors\u003c\/li\u003e \u003cli\u003eEnzymes\u003c\/li\u003e \u003cli\u003ePhysiology and pathophysiology\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWithin each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics.\u003c\/p\u003e \u003cp\u003eEach chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePREFACE ix\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xi\u003c\/p\u003e \u003cp\u003e1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1\u003cbr\u003e \u003ci\u003eHope Mirendil, Mu-En Lin, and Jerold Chun\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41\u003cbr\u003e Bongnam Jung and Timothy Hla\u003c\/p\u003e \u003cp\u003e3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED FIBROBLASTS 61\u003cbr\u003e \u003ci\u003eCatelijne Stortelers and Wouter H. Moolenaar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE (S1P) 71\u003cbr\u003e \u003ci\u003eNitai C. Hait, Sheldon Milstien, and Sarah Spiegel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE KINASE–G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85\u003cbr\u003e \u003ci\u003eNigel J. Pyne and Susan Pyne\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE FUNCTIONS 103\u003cbr\u003e \u003ci\u003eHiroshi Yukiura and Junken Aoki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121\u003cbr\u003e \u003ci\u003eMasayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY 137\u003cbr\u003e \u003ci\u003eJeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex Brown, and Walter A. Shaw\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153\u003cbr\u003e \u003ci\u003eMelissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and Stuart M. Pitson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE TRANSPORTERS 185\u003cbr\u003e \u003ci\u003eAtsuo Kawahara and Tsuyoshi Nishi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS 201\u003cbr\u003e \u003ci\u003eGanesh Venkatraman and David N. Brindley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAY METHODS 229\u003cbr\u003e \u003ci\u003eAndrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D. Renault\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULAR PATHOLOGY 265\u003cbr\u003e \u003ci\u003eSusan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam, and Andrew J. Morris\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING IN CARDIOVASCULAR PHYSIOLOGY AND DISEASE 283\u003cbr\u003e \u003ci\u003eBodo Levkau\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND THE VASCULATURE 313\u003cbr\u003e \u003ci\u003eChristian Waeber\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 REGULATION OF THE NUCLEAR HORMONE RECEPTOR PPARγ BY ENDOGENOUS LYSOPHOSPHATIDIC ACIDS (LPAS) 349\u003cbr\u003e \u003ci\u003eRyoko Tsukahara, Tamotsu Tsukahara, and Gabor Tigyi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 MECHANISMS AND MODELS FOR ELUCIDATING THE CARDIAC EFFECTS OF SPHINGOSINE 1-PHOSPHATE (S1P) 373\u003cbr\u003e \u003ci\u003eShigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell, and Joan Heller Brown\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 NEURAL EFFECTS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING 399\u003cbr\u003e \u003ci\u003eNobuyuki Fukushima\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 WIDESPREAD EXPRESSION OF SPHINGOSINE KINASES AND SPHINGOSINE 1-PHOSPHATE (S1P) LYASE SUGGESTS DIVERSE FUNCTIONS IN THE VERTEBRATE NERVOUS SYSTEM 419\u003cbr\u003e \u003ci\u003eH. Meng and V.M. Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 LYSOPHOSPHATIDIC ACID AND NEUROPATHIC PAIN: DEMYELINATION AND LPA BIOSYNTHESIS 433\u003cbr\u003e \u003ci\u003eHiroshi Ueda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN BEHAVIORAL PROCESSES: IMPLICATIONS FOR PSYCHIATRIC DISORDERS 451\u003cbr\u003e \u003ci\u003eGuillermo Estivill-Torrús, Luis Javier Santín, Carmen Pedraza, Estela Castilla-Ortega, and Fernando Rodríguez de Fonseca\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND LYMPHOCYTE EGRESS 475\u003cbr\u003e \u003ci\u003eAlejandra Mendoza, Lauren A. Pitt, and Susan R. Schwab\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 BIOLOGY REVEALED BY SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR GENE-ALTERED MICE 489\u003cbr\u003e \u003ci\u003eMaria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman Kang, Catherine C. Theisen, Eleanor L. Koerner, and Richard L. Proia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN THE INTESTINE 507\u003cbr\u003e \u003ci\u003eC. Chris Yun and Peijian He\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 LYSOPHOSPHOLIPID SIGNALING IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 529\u003cbr\u003e \u003ci\u003eXiaoqin Ye\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 THE GONADS AND THEIR MAGIC BULLET, LYSOPHOSPHATIDIC ACID: PHYSIOLOGICAL AND TOXICOLOGICAL FUNCTIONS OF LYSOPHOSPHATIDIC ACID (LPA) IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 569\u003cbr\u003e \u003ci\u003eLygia Therese Budnik, Bärbel Brunswig-Spickenheier, and Dieter Müller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 LYSOPHOSPHOLIPID REGULATION OF LUNG FIBROSIS 587\u003cbr\u003e \u003ci\u003eBarry S. Shea and Andrew M. Tager\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE 609\u003cbr\u003e \u003ci\u003eJean Pierre Salles, Sara Laurencin-Dalicieux, Françoise Conte-Auriol, Fabienne Briand-Mésange, and Isabelle Gennero\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE CANCER 627\u003cbr\u003e \u003ci\u003eOlivier Peyruchaud, Marion David, Timothy L. Macdonald, and Kevin R. Lynch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 UNDERSTANDING THE FUNCTIONS OF LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 641\u003cbr\u003e \u003ci\u003eNattapon Panupinthu and Gordon B. Mills\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31 LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 661\u003cbr\u003e \u003ci\u003eAbir Mukherjee, Jinhua Wu, Yongling Gong, and Xianjun Fang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e32 LPA RECEPTOR SUBTYPES LPA1 AND LPA2 AS POTENTIAL DRUG TARGETS 681\u003cbr\u003e \u003ci\u003eGretchen Bain and T. Jon Seiders\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e33 CLINICAL INTRODUCTION OF LYSOPHOSPHATIDIC ACID (LPA) AND AUTOTAXIN ASSAYS 709\u003cbr\u003e \u003ci\u003eYutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda, and Junken Aoki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e34 ANTIBODIES TO BIOACTIVE LYSOPHOSPHOLIPIDS 737\u003cbr\u003e \u003ci\u003eRoger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S. Swaney, and Barbara Visentin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 753\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276364575000,"sku":"9780470569054","price":118.35,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470569054.jpg?v=1781367456","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/lysophospholipid-receptors-signaling-and-biochemistry-hardback-9780470569054","provider":"Freshly Printed Books","version":"1.0","type":"link"}