{"product_id":"introductory-immunology-basic-concepts-for-interdisciplinary-applications-paperback-9780443153075","title":"Introductory Immunology; Basic Concepts for Interdisciplinary Applications (Paperback \/ softback) 9780443153075","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eIntroductory Immunology\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eBasic Concepts for Interdisciplinary Applications\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eProvides an updated and expanded conceptual approach to understanding the immune systems as a primary defense to maintain health and homeostasis\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eJeffrey K. Actor (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780443153075, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 6 February 2023\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e224 pages\u003cbr\u003e22.9 x 15.2 x 1.5 cm, 0.45 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eIntroductory Immunology: Basic Concepts for Interdisciplinary Applications, 3rd Edition\u003c\/i\u003e, is a completely updated, revised, and expanded concise, conceptual approach to understanding the immune systems as a primary defense to maintain health and homeostasis. This expanded version includes the aspects of microbiology and related immune defense mechanisms important in combating disease, as well critical components related to the field of vaccine development.\u003c\/p\u003e  \u003cp\u003eImmunology as a subject is no longer confined to the realms of \"immunology\" or \"microbiology\" studies. Indeed, the subject matter has become increasingly important to understand complex mechanisms found within a wider range of biological systems. This book aims specifically at educated audiences who do not have a deep understanding of medical, biochemical, or cellular knowledge. The overall text will present concepts that portray a comprehensive picture of the natural defenses to infectious agents as well as provide an introduction to mechanisms that lead to autoimmune dysfunction. In addition, immunological diseases will be detailed, with the goal of allowing the readers to gain sufficient knowledge to make sound choices for clinical decisions to affect treatment outcomes.\u003c\/p\u003e  \u003cp\u003eThis new edition expands on the existing chapters, focusing on updating the previous text. It has been expanded to include knowledge on effector mechanisms addressing components inherent within cellular responses that are either newly discovered, or missing from the previous edition. It has an extra emphasis on aspects related to mechanisms important in combating microbial agents and critical sections on how vaccines protect against pathogenic invaders to limit associated pathology.\u003c\/p\u003e  \u003cp\u003eThe goal is that \u003ci\u003eIntroductory Immunology\u003c\/i\u003e will become the preferred provider of core knowledge in immunology to build a foundation to explore components of the human immune system that work together to confer and understand dysregulation that causes clinical diseases. This book serves as a basic platform to define therapeutic interventions by:\u003c\/p\u003e  \u003cul\u003e  \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003ecreating appreciation for components of the human immune system to work together to confer lifelong protection;\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eproviding a core knowledge in immunology to build a foundation to explore mechanisms involved in clinical disease, and defining functional aspects of immunological terms to permit the reader easy access to comprehend specific topics;\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003epresenting introduction to complex immunological concepts in a concise and easy manner that relates to clinical disease;\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003ebreaking down all of immunology into manageable, logically digestible building blocks, and providing a map to explore overlapping mechanisms of immune protective responses;\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eproviding a platform to readers without medical, biochemical, or cellular expertise to understand and appreciate how immunology controls homeostasis and protects against pathogens.\u003c\/li\u003e \u003c\/ul\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface  Acknowledgments \u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. A functional overview of the immune system and components\u003c\/b\u003e Chapter focus Immune homeostasis  Self versus nonself  Innate and adaptive immunity  Anatomy of the immune system  Cells of the immune system  First-line defenders: the myeloid cells  Adaptive avengers: the lymphoid cells  Lymphocytes  Cluster of differentiation  Summary \u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. The inflammatory response\u003c\/b\u003e  Chapter focus  Inflammation  Initiation of the inflammatory response  The role of antibodies in inflammation  Biological functions of complement  Activation and directed migration of leukocytes  Pathogen recognition and cytokine signaling  Feedback and adaptation from a distance  Pathological consequences of the inflammatory Response  Summary \u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. The B lymphocyte: antibodies and how they function  \u003c\/b\u003eChapter focus  B lymphocytes produce antibodies  Structural characteristics of immunoglobulins  Immunoglobulin nomenclature  Biologic properties of antibody isotypes  IgD  IgM  IgG  IgA  IgE  Kinetics of antibody response  Membrane-bound immunoglobulin  Development of B cells  Antibody gene recombination  Development and selection of mature B cells  Activation and differentiation of B cells  Summary \u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. T lymphocytes: ringleaders of adaptive immune function\u003c\/b\u003e  Chapter focus  T lymphocytes: specific and long-lasting immunity  The T cell receptor  T-cell development  Antigen recognition by T cells: requirement of major histocompatibility molecules  The HLA locus  MHC class I  MHC class II  T lymphocyte functions  CD4 1 T-helper cells  Events involved in T lymphocyte activation  Role of T cells in B-cell activation  Cytotoxic T-cell effectors  CD8 1 T cells  Other lymphocyte phenotypes  ?d T cells  Innate lymphocytes  Natural killer T (NKT) cells  Superantigens  Summary \u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. How we defend against infectious agents\u003c\/b\u003e  Chapter focus  Immune homeostasis and pathogenic organisms  Major immune defense mechanisms against pathogens  Physical barriers to infection  Anatomic barrier  Physiological barrier  Phagocytic and endocytic barriers  Inflammatory barriers  Bacterial infections  Microbial motifs detected through pattern-recognition receptors  Mycobacterial infections  Viral infections  Human immunodeficiency virus  Parasitic infections (helminths)  Fungal infections Evasion of immune response  Summary \u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Basic disorders of immune function\u003c\/b\u003e  Chapter focus  Immunodeficiency disorders  Genetic basis for primary immunodeficiency  Innate deficiencies  Chronic granulomatous disease\/myeloperoxidase deficiency  Leukocyte adhesion deficiency  Chediak\u003chigashi complement disorders innate pattern-recognition receptor adaptive immune x-linked agammaglobulinemia selective immunoglobulin a deficiency common variable immunodeficiency hyper m digeorge syndrome wiskott severe combined treatment of diseases as predisposition to disease human virus and acquired summary\u003e \u003cp\u003e\u003cb\u003e7. Autoimmunity: regulation of response to self\u003c\/b\u003e Chapter focus Homeostasis, immune regulation, and autoimmunity Tolerance to self Etiology of autoimmune disease Role of autoantibodies and self-reactive T lymphocytes in autoimmune disorders Laboratory tests for autoimmunity Targeted therapeutics Summary\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. Immune hypersensitivities \u003c\/b\u003eChapter focus Hypersensitive disorders Type I hypersensitivity: immunoglobulin E\u003cmediated hypersensitivity type ii hypersensitivity: antibody-mediated cytotoxic iii immune complex-mediated iv delayed-type alternative classifications summary\u003e \u003cp\u003e\u003cb\u003e9. Vaccines and immunotherapy \u003c\/b\u003eChapter focus Principles of vaccination Basic concepts of protective immunization Types of immunizations Age and timing of immunizations Vaccine types and components Immunologic adjuvants Passive immunization Therapeutic uses of immunoglobulins Other ways to modify immunity Summary\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. Cancer immunology\u003c\/b\u003e  Chapter focus Understanding immune defenses against cancers Tumor antigens Effector mechanisms in tumor immunity Natural killer cells and innate response to tumor cells Adaptive response to tumor cells Escape mechanisms of tumor elimination Tumors of the immune system Immunodiagnosis and immunotherapy Summary\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11. Transplantation immunology\u003c\/b\u003e Chapter focus Transplantation defined Tissue histocompatibility Natural isohemagglutinins Human leukocyte antigens Allograft rejection Hyperacute rejection Accelerated rejection Acute rejection Chronic rejection Graft-versus-host disease Pretransplantation histocompatibility evaluation Immunosuppressive drugs to prevent allograft rejection Immunosuppressive therapy Summary\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12. Assessment of immune parameters and immunodiagnostics \u003c\/b\u003eChapter focus Antibody\u003cantigen reactions affinity secondary manifestations of antibody binding solid-phase precipitation assays radial immunodiffusion the ouchterlony assay immunoelectrophoresis latex agglutination lateral flow western blot immunoassays enzyme-linked immunoadsorbent detection cellular antigens immunohistochemistry fluorescence-activated cell sorting analysis multiplex bead arrays to determine immune function complement fixation test phagocyte lymphocyte other tools measure immunological status monoclonal antibodies microarrays summary glossary index\u003e\u003c\/antigen\u003e\u003c\/p\u003e\u003c\/mediated\u003e\u003c\/p\u003e\u003c\/higashi\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Immunology [\u003ca title=\"See our other books on Immunology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Immunology%20%5BMJCM%5D%22\"\u003eMJCM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46651405795608,"sku":"9780443153075","price":68.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780443153075.jpg?v=1694979790","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/introductory-immunology-basic-concepts-for-interdisciplinary-applications-paperback-9780443153075","provider":"Freshly Printed Books","version":"1.0","type":"link"}