{"product_id":"integration-of-biomaterials-for-gene-therapy-hardback-9781394174737","title":"Integration of Biomaterials for Gene Therapy (Hardback) 9781394174737","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eIntegration of Biomaterials for Gene Therapy\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eRishabha Malviya (Edited by), Malviya (Author), Sonali Sundram (Edited by), Neelam Jain (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781394174737, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 2 May 2024\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e464 pages\u003cbr\u003e22.9 x 15.2 x 2.8 cm, 0.826 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cb\u003eINTEGRATION OF BIOMATERIALS FOR GENE THERAPY\u003c\/b\u003e \u003cp\u003e\u003cb\u003eBrings industrial practitioners and researchers together to discuss how the deeper integration of biomaterial platforms could play a significant role in enabling breakthroughs in the application of gene editing for the treatment of human disease.\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003eThis book comprises research and review articles from leading researchers with multidisciplinary experience. It discusses many broad topics, including nanoparticle-enabled gene therapy, inorganic nanocarrier-based gene delivery, non-viral delivery of nucleic acid, biocompatible hydrogels, silk, and polysaccharides-based gene delivery. Other gene delivery topics discussed include the use of smart and engineered biomaterials, combined therapy with growth factors and cell transportation, and the prospects and challenges in the treatment of different diseases, including cancer. \u003c\/p\u003e\n\u003cp\u003eThis book bridges the knowledge of pharmaceutics, engineering, basic science, and clinical research fields in a way that will help the research community expedite the clinical application of these therapies for various diseases and conditions. \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eAudience\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003eA broad range of researchers, scientists, and engineers in diverse fields such as materials science, biomedicine, biomedical engineering, biology, chemistry, physics, biotechnology, pharmacology, toxicology, and formulation scientists.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eForeword xvii\u003c\/p\u003e \u003cp\u003ePreface xix\u003c\/p\u003e \u003cp\u003eAcknowledgment xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Biocompatible Hydrogels for Gene Therapy: Advancement and Applications 1\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAnkita Gupta and Swatantra K.S. Kushwaha\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 2\u003c\/p\u003e \u003cp\u003e1.2 Hydrogels Classification 3\u003c\/p\u003e \u003cp\u003e1.3 Fabrication of Hydrogels and Its Desirable Technical Features 4\u003c\/p\u003e \u003cp\u003e1.4 Factors to be Tuned for Gene Encapsulation in Hydrogels 4\u003c\/p\u003e \u003cp\u003e1.5 Recent Advances on Hydrogels for Gene Delivery 6\u003c\/p\u003e \u003cp\u003e1.6 Conclusion 9\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Use of Polysaccharides: Novel Delivery System for Genetic Material 13\u003c\/b\u003e\u003cbr\u003e\u003ci\u003ePrashant Kumar, Swatantra K.S. Kushwaha, Neelottama Kushwaha, Abhishek Singh and Surya Nath Pandey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 14\u003c\/p\u003e \u003cp\u003e2.2 Cross-Linking Techniques for Engineering Polysaccharides-Based Biomaterials 23\u003c\/p\u003e \u003cp\u003e2.3 Approaches to Design Polysaccharide-Derived Biomaterials 26\u003c\/p\u003e \u003cp\u003e2.4 Biomedical Applications of Polysaccharide-Derived Biomaterials 29\u003c\/p\u003e \u003cp\u003e2.5 Advanced Biomaterials for Wound Dressings 30\u003c\/p\u003e \u003cp\u003e2.6 Scaffolds for Tissue Engineering and Development of Bioinks for 3D Bioprinting 30\u003c\/p\u003e \u003cp\u003e2.7 Recent Utilization of Polysaccharides 31\u003c\/p\u003e \u003cp\u003e2.8 Toxicity Concerns of Polysaccharide-Derived Biomaterials 33\u003c\/p\u003e \u003cp\u003e2.9 Preclinical and Clinical Studies on Gene Delivery Using Polysaccharide-Based Biomaterials 33\u003c\/p\u003e \u003cp\u003e2.10 Challenges and Future Directions 34\u003c\/p\u003e \u003cp\u003e2.11 Future Prospects 35\u003c\/p\u003e \u003cp\u003e2.12 Conclusion 35\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Polysaccharide-Based Biomaterials for Gene Delivery 47\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAnkita Moharana, Abhitav Tiwari, Shalini Perada, Shivlal Yadav and Om Prakash Kumar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Background 48\u003c\/p\u003e \u003cp\u003e3.2 Introduction 49\u003c\/p\u003e \u003cp\u003e3.3 Gene Therapy 51\u003c\/p\u003e \u003cp\u003e3.4 Gene Delivery Systems Based on Polysaccharides 53\u003c\/p\u003e \u003cp\u003e3.5 Practical Application of Gene Delivery Systems 56\u003c\/p\u003e \u003cp\u003e3.6 Polysaccharide-Based Nanoparticles 57\u003c\/p\u003e \u003cp\u003e3.7 DNA Delivery 63\u003c\/p\u003e \u003cp\u003e3.7.1 siRNA Delivery 65\u003c\/p\u003e \u003cp\u003e3.8 Conclusion 70\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Hydrogel-Based Gene Therapy 77\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eShweta Kumari, Dipti Jena, Vedant Kumar Prajapati, Shashi Ranjan Singh and Garima Tripathi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 78\u003c\/p\u003e \u003cp\u003e4.2 Gene Therapy 83\u003c\/p\u003e \u003cp\u003e4.3 In Vivo Gene Therapy Using Hydrogels 86\u003c\/p\u003e \u003cp\u003e4.4 Encapsulating Cells in Hydrogels for Gene Therapy Delivery 87\u003c\/p\u003e \u003cp\u003e4.5 Hydrogels for Integrative Tissue Engineering and Cell Delivery 89\u003c\/p\u003e \u003cp\u003e4.6 Biocompatible Hydrogels for Transferring Cells 91\u003c\/p\u003e \u003cp\u003e4.7 Using Hydrogels for Gene Therapy in Tissue Engineering-Based Drug 93\u003c\/p\u003e \u003cp\u003e4.8 Human Gene Therapy that Uses Hydrogel as an Alternative Method of Delivering Genetic Material to Patients 94\u003c\/p\u003e \u003cp\u003e4.9 Recent Advancement in Biocompatible Hydrogel 96\u003c\/p\u003e \u003cp\u003e4.10 Applications of Hydrogel 99\u003c\/p\u003e \u003cp\u003e4.11 Current Hydrogels in Clinical Trials 104\u003c\/p\u003e \u003cp\u003e4.12 Conclusions 106\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Progress and Prospects for Non-Viral Gene Therapy 117\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eShashimala Tiwari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 118\u003c\/p\u003e \u003cp\u003e5.2 Definition 118\u003c\/p\u003e \u003cp\u003e5.3 Technology Overview for Non-Viral Gene Delivery 119\u003c\/p\u003e \u003cp\u003e5.4 Chemical Carriers for Gene Transfer: Establishing Effective In Vivo Gene Delivery 121\u003c\/p\u003e \u003cp\u003e5.5 Types of Gene Delivery 122\u003c\/p\u003e \u003cp\u003e5.6 Reduction of Immunological Responses Through Alteration of Delivery Method or DNA Structure 124\u003c\/p\u003e \u003cp\u003e5.7 To Enable Long-Lasting Gene Expression, Self-Replicating, Tissue-Specific, and Integrating Plasmid\u003c\/p\u003e \u003cp\u003eExpression Systems are Designed 124\u003c\/p\u003e \u003cp\u003e5.8 Hybrid Vector Systems to Improve Transfection and Lessen Cytotoxicity 125\u003c\/p\u003e \u003cp\u003e5.9 Vehicle Material 127\u003c\/p\u003e \u003cp\u003e5.10 Further Effects 129\u003c\/p\u003e \u003cp\u003e5.11 Challenges and Prospects 130\u003c\/p\u003e \u003cp\u003e5.12 Conclusion 132\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Nanoparticles for Tumor Gene Therapy: Recent Advances and Perspective 139\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eR. Shivhare, V. Sabale, A. Ingole and Neelam Jain\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 140\u003c\/p\u003e \u003cp\u003e6.2 Technologies for Gene Delivery 142\u003c\/p\u003e \u003cp\u003e6.3 Cancer Treatment with Gene Therapy 147\u003c\/p\u003e \u003cp\u003e6.4 Gene Therapy Using Nanotechnology 147\u003c\/p\u003e \u003cp\u003e6.5 Challenges and Future Aspects 160\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Effective Gene Transfer with Non-Viral Vectors 183\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAnil Kumar Mavi, Sonal Gaur, Neelesh Kumar, Avanish Kumar Shrivastav, Sankha Bhattacharya,\u003c\/i\u003e\u003cbr\u003e\u003ci\u003eSateesh Belemkar, Saurabh Maru and Dhruv Kumar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 184\u003c\/p\u003e \u003cp\u003e7.2 System Development for Delivering Genes 186\u003c\/p\u003e \u003cp\u003e7.3 Methods for Non-Viral Vector for Delivery of Genes 186\u003c\/p\u003e \u003cp\u003e7.4 Delivery System 203\u003c\/p\u003e \u003cp\u003e7.5 Current Methods for Nonviral Gene Delivery: Benefits and Drawbacks 209\u003c\/p\u003e \u003cp\u003e7.6 Current Barriers for Non-Viral Vectors 210\u003c\/p\u003e \u003cp\u003e7.7 Possibilities for Enhancing the Non-Viral Vector Delivery System 212\u003c\/p\u003e \u003cp\u003e7.8 Conclusion 212\u003c\/p\u003e \u003cp\u003e7.9 Future Relevance 213\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Utilization of Chitosan for Gene Delivery 223\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJohnson Olaleye Oladele\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 224\u003c\/p\u003e \u003cp\u003e8.2 Cationic Polymers-Based Gene Delivery Systems 225\u003c\/p\u003e \u003cp\u003e8.3 Chitosan and Its Derivatives in Gene Delivery Systems 228\u003c\/p\u003e \u003cp\u003e8.4 Chitosan as Chemotherapeutic Drugs 234\u003c\/p\u003e \u003cp\u003e8.5 Conclusion 236\u003c\/p\u003e \u003cp\u003e9 Nanoparticles as Gene Vectors in Tumor Therapy 247\u003c\/p\u003e \u003cp\u003eEfstathia Triantafyllopoulou, Orestis Kontogiannis, Nefeli Lagopati, Natassa Pippa and Maria Gazouli\u003c\/p\u003e \u003cp\u003e9.1 Introduction 248\u003c\/p\u003e \u003cp\u003e9.2 Polymer-Based Nanocarriers: Their Technology and Recent Advances 249\u003c\/p\u003e \u003cp\u003e9.3 Conclusions 271\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Progress in Non-Viral Delivery of Nucleic Acid: Advancement in Biomedical Technology 281\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAnil Kumar Mavi, Manmohan Kumar, Amarjeet Singh, Mahendra Kumar Prajapati, Rakhi Khabiya, Saurabh Maru and Dhruv Kumar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 282\u003c\/p\u003e \u003cp\u003e10.2 Physical Methods of Non-Viral Nucleic Acid Delivery System 285\u003c\/p\u003e \u003cp\u003e10.3 Advantages and Disadvantages of Physical Transfection 296\u003c\/p\u003e \u003cp\u003e10.4 Chemical Methods of Non-Viral Nucleic Acid Delivery System 296\u003c\/p\u003e \u003cp\u003e10.5 Advantages and Disadvantages of Chemical Transfection 308\u003c\/p\u003e \u003cp\u003e10.6 Cellular Barriers for Nucleic Acid Delivery Faced by Non-Viral Vectors 309\u003c\/p\u003e \u003cp\u003e10.7 Challenges and Limitations of Non-Viral Nucleic Acid Delivery System 311\u003c\/p\u003e \u003cp\u003e10.8 Conclusion 311\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 The Junction of Biomaterials and Gene Therapy -- Current Strategies and Future Directions 323\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRanjan Kumar Singh, Sunita Panchawat, Chennu M.M. Prasada Rao, Joohee Pradhan, Rajeswari Tanniru, Deepika Bairagee and Ajay Kumar Garg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 324\u003c\/p\u003e \u003cp\u003e11.2 Viral Gene Therapy 327\u003c\/p\u003e \u003cp\u003e11.3.1 Adenoviral Vectors 329\u003c\/p\u003e \u003cp\u003e11.4 Adeno-Associated Viral Vectors 330\u003c\/p\u003e \u003cp\u003e11.5 Non-Viral Gene Therapy 331\u003c\/p\u003e \u003cp\u003e11.6 Recent Advances in the Development of Gene Delivery Systems 334\u003c\/p\u003e \u003cp\u003e11.7 Development of Gene Delivery Systems 335\u003c\/p\u003e \u003cp\u003e11.8 Viral Vectors Based on DNA for Gene Delivery Systems 336\u003c\/p\u003e \u003cp\u003e11.9 Viral Vectors Based on RNA for Gene Delivery Systems 337\u003c\/p\u003e \u003cp\u003e11.10 Oncolytic Viral Vectors for Gene Delivery Systems 337\u003c\/p\u003e \u003cp\u003e11.11 Practical Application of Gene Delivery Methods 343\u003c\/p\u003e \u003cp\u003e11.12 Conclusion 347\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Utilization of Silk for Gene Delivery 349\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSwatantra K. S. Kushwaha, Shruti Khare and Neelottama Kushwaha\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 350\u003c\/p\u003e \u003cp\u003e12.2 Dimensional Structure of Silk 350\u003c\/p\u003e \u003cp\u003e12.3 Properties of Silk 351\u003c\/p\u003e \u003cp\u003e12.4 Extraction of Fibroin from Silk Worm 352\u003c\/p\u003e \u003cp\u003e12.5 Fabrication of Silk in Different Therapeutics Carriers 353\u003c\/p\u003e \u003cp\u003e12.6 Utilization of Silk for Gene Therapy 354\u003c\/p\u003e \u003cp\u003e12.7 Properties of Silk Fibroin as Biomaterial 355\u003c\/p\u003e \u003cp\u003e12.8 Summary of Silk-Based Formulations for Gene Delivery 357\u003c\/p\u003e \u003cp\u003e12.9 Examples of Some Delivery Approaches which Utilizes Silk as a Biomaterial for Gene Delivery 358\u003c\/p\u003e \u003cp\u003e12.10 Some Highlights of Silk Fibroin 360\u003c\/p\u003e \u003cp\u003e12.11 Conclusion 360\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Challenges and Emerging Problems in Nanomedicine Mediated Gene Therapy 367\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eShalini Bhatt, Neha Faridi, Rakshit Pathak, Vinay Deep Punetha and Mayank Punetha\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 368\u003c\/p\u003e \u003cp\u003e13.2 Why Nanomedicine Over Traditional Drugs? 369\u003c\/p\u003e \u003cp\u003e13.3 Nanomedicine for Gene Therapy 373\u003c\/p\u003e \u003cp\u003e13.4 Complications in Nanomedicine-Mediated Gene Therapy 384\u003c\/p\u003e \u003cp\u003e13.5 Challenges in the Clinical Translation of Nanomedicines 391\u003c\/p\u003e \u003cp\u003e13.6 Conclusion 396\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Biomaterials-Based Vaccination in Cancer Therapy 417\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRishav Sharma, Rishabha Malviya and Sonali Sundram\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 417\u003c\/p\u003e \u003cp\u003e14.2 Tumor-Associated Antigens 418\u003c\/p\u003e \u003cp\u003e14.3 Vaccine Delivery 419\u003c\/p\u003e \u003cp\u003e14.4 Dendritic Cells 420\u003c\/p\u003e \u003cp\u003e14.5 In Vitro Generation of Dendritic Cells 421\u003c\/p\u003e \u003cp\u003e14.6 Usage of RNA 422\u003c\/p\u003e \u003cp\u003e14.7 RNA-Pulsed DCs as Vaccines 422\u003c\/p\u003e \u003cp\u003e14.8 RNA Vaccines 425\u003c\/p\u003e \u003cp\u003e14.9 Optimization of Immunotherapy 426\u003c\/p\u003e \u003cp\u003e14.10 Cancer Treatment Through RNA Interference 427\u003c\/p\u003e \u003cp\u003e14.11 Conclusion 428\u003c\/p\u003e \u003cp\u003eReferences 429\u003c\/p\u003e \u003cp\u003eIndex 435\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Jurisprudence \u0026amp; general issues [\u003ca title=\"See our other books on Jurisprudence \u0026amp; general issues\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Jurisprudence%20\u0026amp;%20general%20issues%20%5BLA%5D%22\"\u003eLA\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Scrivener","offers":[{"title":"Brand New","offer_id":52431056306456,"sku":"9781394174737","price":158.29,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781394174737.jpg?v=1784770154","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/integration-of-biomaterials-for-gene-therapy-hardback-9781394174737","provider":"Freshly Printed Books","version":"1.0","type":"link"}