{"product_id":"inhaled-medicines-optimizing-development-through-integration-of-in-silico-in-vitro-and-in-vivo-approaches-paperback-9780128149744","title":"Inhaled Medicines; Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches (Paperback) 9780128149744","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eInhaled Medicines\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eOptimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eResponds to a need for well-designed protocols to evaluate emerging in silico methods for inhaled drug development\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eStavros Kassinos (Edited by), Per Bäckman (Edited by), Joy Conway (Edited by), Anthony J. Hickey (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128149744, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 22 January 2021\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e438 pages\u003cbr\u003e23.5 x 19 x 2.8 cm, 0.88 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"I have never reviewed a book that was entirely dedicated to just one method of drug delivery, so this seems to be a rather complete text. Future technologies are featured, but when they become reality, additional drug exploration will warrant an updated edition. Weighted Numerical Score: 100 - 5 Stars!\" \u003cb\u003e--© Doody’s Review Service, 2021, Patrick J. McDonnell, reviewer, expert opinion\u003c\/b\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eInhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes.\u003c\/p\u003e\n\u003ci\u003e  \u003c\/i\u003e\u003cp\u003eInhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments.\u003c\/p\u003e\n\u003ci\u003e  \u003c\/i\u003e\u003cp\u003e \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e1. Historical perspective - Disruptive technologies and strategies 2. The API 3. Devices and formulations: General introduction and wet aerosol delivery systems 4. Metered dose inhalers (MDIs) 5. Dry powder inhalers (DPIs) 6. In vitro methods to study dose deposition 7. In silico methods to model dose deposition 8. Non-absorptive clearance from airways 9. Dissolution and drug release 10. Epithelial permeability and drug absorption in the lungs 11. Drug distribution in lung tissue 12. Physiologically-based pharmacokinetic modeling after drug inhalation 13. Inhaled aerosols: Emerging clinical methods 14. Machine learning and in silico methods 15. The emerging state of the art \u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Pharmaceutical industries [\u003ca title=\"See our other books on Pharmaceutical industries\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20industries%20%5BKNDP%5D%22\"\u003eKNDP\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46648523686168,"sku":"9780128149744","price":129.88,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128149744.jpg?v=1694092067","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/inhaled-medicines-optimizing-development-through-integration-of-in-silico-in-vitro-and-in-vivo-approaches-paperback-9780128149744","provider":"Freshly Printed Books","version":"1.0","type":"link"}