{"product_id":"in-silico-dreams-how-artificial-intelligence-and-biotechnology-will-create-the-medicines-of-the-future-paperback-softback-9781119745570","title":"In Silico Dreams; How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future (Paperback \/ softback) 9781119745570","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eIn Silico Dreams\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eHow Artificial Intelligence and Biotechnology Will Create the Medicines of the Future\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eBrian S. Hilbush (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781119745570, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 4 October 2021\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e352 pages\u003cbr\u003e22.4 x 15 x 2.3 cm, 0.454 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eLearn how AI and data science are upending the worlds of biology and medicine\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIn Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future\u003c\/i\u003e delivers an illuminating and fresh perspective on the convergence of two powerful technologies: AI and biotech. Accomplished genomics expert, executive, and author Brian Hilbush offers readers a brilliant exploration of the most current work of pioneering tech giants and biotechnology startups who have already started disrupting healthcare. The book provides an in-depth understanding of the sources of innovation that are driving the shift in the pharmaceutical industry away from serendipitous therapeutic discovery and toward engineered medicines and curative therapies.\u003c\/p\u003e \u003cp\u003eIn this fascinating book, you'll discover:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eAn overview of the rise of data science methods and the paradigm shift in biology that led to the in silico revolution\u003c\/li\u003e \u003cli\u003eAn outline of the fundamental breakthroughs in AI and deep learning and their applications across medicine\u003c\/li\u003e \u003cli\u003eA compelling argument for the notion that AI and biotechnology tools will rapidly accelerate the development of therapeutics\u003c\/li\u003e \u003cli\u003eA summary of innovative breakthroughs in biotechnology with a focus on gene editing and cell reprogramming technologies for therapeutic development\u003c\/li\u003e \u003cli\u003eA guide to the startup landscape in AI in medicine, revealing where investments are poised to shape the innovation base for the pharmaceutical industry\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003ePerfect for anyone with an interest in scientific topics and technology, \u003ci\u003eIn Silico Dreams\u003c\/i\u003e also belongs on the bookshelves of decision-makers in a wide range of industries, including healthcare, technology, venture capital, and government.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eIntroduction xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1 The Information Revolution’s Impact on Biology 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA Biological Data Avalanche at Warp Speed 5\u003c\/p\u003e \u003cp\u003eTracking SARS-CoV-2 with Genomic Epidemiology 11\u003c\/p\u003e \u003cp\u003eBiology’s Paradigm Shift Enables \u003ci\u003eIn Silico \u003c\/i\u003eBiology 17\u003c\/p\u003e \u003cp\u003eTransitions and Computation in Cancer Research 18\u003c\/p\u003e \u003cp\u003eStructural Biology and Genomics 24\u003c\/p\u003e \u003cp\u003eSequencing the Human Genome 27\u003c\/p\u003e \u003cp\u003eComputational Biology in the Twenty-First Century 33\u003c\/p\u003e \u003cp\u003eApplications of Human Genome Sequencing 35\u003c\/p\u003e \u003cp\u003eAnalyzing Human Genome Sequence Information 37\u003c\/p\u003e \u003cp\u003eOmics Technologies and Systems Biology 40\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2 A New Era of Artificial Intelligence 53\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAI Steps Out of the Bronx 55\u003c\/p\u003e \u003cp\u003eFrom Neurons and Cats Brains to Neural Networks 58\u003c\/p\u003e \u003cp\u003eMachine Learning and the Deep Learning Breakthrough 66\u003c\/p\u003e \u003cp\u003eDeep Learning Arrives for AI 73\u003c\/p\u003e \u003cp\u003eDeep Neural Network Architectures 75\u003c\/p\u003e \u003cp\u003eDeep Learning’s Beachhead on Medicine: Medical Imaging 78\u003c\/p\u003e \u003cp\u003eLimitations on Artificial Intelligence 83\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3 The Long Road to New Medicines 91\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMedicine’s Origins: The Role of Opium Since the Stone Age 96\u003c\/p\u003e \u003cp\u003eIndustrial Manufacturing of Medicines 102\u003c\/p\u003e \u003cp\u003ePaul Ehrlich and the Birth of Chemotherapeutic Drug Discovery 108\u003c\/p\u003e \u003cp\u003eThe Pharmaceutical Industry: Drugs and War—New Medicines in the Twentieth Century 112\u003c\/p\u003e \u003cp\u003eFrom Synthetic Antibiotics to the Search for New Drugs from the Microbial World 116\u003c\/p\u003e \u003cp\u003eDeveloping Therapeutics for Cancer 119\u003c\/p\u003e \u003cp\u003eAntifolates and the Emergence of DNA Synthesis Inhibitors 120\u003c\/p\u003e \u003cp\u003eAntibiotics as Cancer Chemotherapeutic Drugs 123\u003c\/p\u003e \u003cp\u003eImmunotherapy 125\u003c\/p\u003e \u003cp\u003eThe Pharmaceutical Business Model in the Twenty-First Century 126\u003c\/p\u003e \u003cp\u003eR\u0026amp;D Productivity Challenges Within the Pharmaceutical Industry 131\u003c\/p\u003e \u003cp\u003eSources of Pharmaceutical Innovation: Biotechnology and New Therapeutic Modalities 135\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4 Gene Editing and the New Tools of Biotechnology 145\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMolecular Biology and Biological Information Flow 150\u003c\/p\u003e \u003cp\u003eManipulating Gene Information with Recombinant DNA Technology 154\u003c\/p\u003e \u003cp\u003eGenetics, Gene Discovery, and Drugs for Rare Human Diseases 160\u003c\/p\u003e \u003cp\u003eSecond-Generation Biotechnology Tools: CRISPR- Cas9 and Genome Editing Technologies 167\u003c\/p\u003e \u003cp\u003eHuman Genome Editing and Clinical Trials 171\u003c\/p\u003e \u003cp\u003eBiotechnology to the Rescue: Vaccine Development Platforms Based on Messenger RNA 179\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5 Healthcare and the Entrance of the Technology Titans 189\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDigital Health and the New Healthcare Investment Arena 191\u003c\/p\u003e \u003cp\u003eAssessing the Tech Titans as Disruptors in Healthcare 195\u003c\/p\u003e \u003cp\u003eAlphabet: Extending Its Tentacles Into Healthcare with Google and Other Bets 196\u003c\/p\u003e \u003cp\u003eApple Inc: Consumer Technology Meets Healthcare 200\u003c\/p\u003e \u003cp\u003eAmazon: Taking Logistics to the Next Level for Delivering Healthcare 204\u003c\/p\u003e \u003cp\u003eEchoes of the Final Frontier 207\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6 AI-Based Algorithms in Biology and Medicine 211\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRecognizing the Faces of Cancer 217\u003c\/p\u003e \u003cp\u003eTumor Classification Using Deep Learning with Genomic Features 222\u003c\/p\u003e \u003cp\u003eAI for Diseases of the Nervous System: Seeing and Changing the Brain 229\u003c\/p\u003e \u003cp\u003eRegulatory Approval and Clinical Implementation: Twin Challenges for AI-Based Algorithms in Medicine 234\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7 AI in Drug Discovery and Development 245\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA Brief Survey of \u003ci\u003eIn Silico \u003c\/i\u003eMethods in Drug Discovery 247\u003c\/p\u003e \u003cp\u003eVirtual Screening with Cheminformatics and HTS Technologies 250\u003c\/p\u003e \u003cp\u003eAI Brings a New Toolset for Computational Drug Design 252\u003c\/p\u003e \u003cp\u003eAI-Based Virtual Screening Tools 257\u003c\/p\u003e \u003cp\u003eGenerative Models for De Novo Drug Design 257\u003c\/p\u003e \u003cp\u003eA New Base of Innovation for the Pharmaceutical Industry 259\u003c\/p\u003e \u003cp\u003eAtomwise 261\u003c\/p\u003e \u003cp\u003eRecursion Pharmaceuticals 262\u003c\/p\u003e \u003cp\u003eDeep Genomics 262\u003c\/p\u003e \u003cp\u003eRelay Therapeutics 263\u003c\/p\u003e \u003cp\u003eSummary 265\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8 Biotechnology, AI, and Medicine’s Future 269\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eBuilding Tools to Decipher Molecular Structures and Biological Systems 272\u003c\/p\u003e \u003cp\u003eAlphaFold: Going Deep in Protein Structure Prediction 274\u003c\/p\u003e \u003cp\u003ePredicting Genome 3D Organization and Regulatory Elements 276\u003c\/p\u003e \u003cp\u003eAI Approaches to Link Genetics-Based Targets to Disease 277\u003c\/p\u003e \u003cp\u003eQuantum Computing for In Silico Chemistry and Biology 278\u003c\/p\u003e \u003cp\u003eNeuroscience and AI: Modeling Brain and Behavior 280\u003c\/p\u003e \u003cp\u003eBrain Information Processing and Modularity: Climbing a Granite Wall 283\u003c\/p\u003e \u003cp\u003eEngineering Medicines with Biotechnology and AI 289\u003c\/p\u003e \u003cp\u003eGlossary 295\u003c\/p\u003e \u003cp\u003eIndex 303\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Medicine: general issues [\u003ca title=\"See our other books on Medicine: general issues\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Medicine:%20general%20issues%20%5BMB%5D%22\"\u003eMB\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52501435416856,"sku":"9781119745570","price":24.69,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781119745570.jpg?v=1786238653","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/in-silico-dreams-how-artificial-intelligence-and-biotechnology-will-create-the-medicines-of-the-future-paperback-softback-9781119745570","provider":"Freshly Printed Books","version":"1.0","type":"link"}