{"product_id":"immunotoxicology-strategies-for-pharmaceutical-safety-assessment-hardback-9780470122389","title":"Immunotoxicology Strategies for Pharmaceutical Safety Assessment (Hardback) 9780470122389","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eImmunotoxicology Strategies for Pharmaceutical Safety Assessment\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eDanuta J. Herzyk (Edited by), DJ Herzyk (Author), Jeanine L. Bussiere (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470122389, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 12 September 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e444 pages\u003cbr\u003e24.4 x 16.4 x 2.6 cm, 0.748 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"I would recommend this book to toxicologists wishing to develop their knowledge in the specialised field of immunotoxicology. The book provides extremely clear indication on the assessment of immunotoxicology and contains many recent references at the end of each chapter.\" (\u003ci\u003eBTS Newsletter\u003c\/i\u003e, Summer 2009)\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cul\u003e \u003cli\u003eAn important reference which provides an overview of the current and recently introduced methodologies for testing the immunotoxic risks in drug candidates\u003c\/li\u003e \u003cli\u003eHelps readers understand the significance of the methods and approaches to immunotoxicology testing\u003c\/li\u003e \u003cli\u003eAids drug scientists in industry and regulatory areas to consolidate approaches to immunotox testing\u003c\/li\u003e \u003cli\u003eOffers a definitive assessment of nonclinical models to study the toxic impacts (bio)pharmaceuticals can have on the immune system\u003c\/li\u003e \u003cli\u003eIncludes chapter authors from across the pharma industry, bringing a real-world and applied perspective to immunotox testing\u003c\/li\u003e \u003c\/ul\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003eIntroduction to Immunotoxicology xvii\u003cbr\u003e\u003ci\u003eJack H. Dean\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Current Regulatory Expectations For Immunotoxicity Evaluation Of Pharmaceuticals 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Current Regulatory Expectations for Immunotoxicity Evaluation of Pharmaceuticals 3\u003cbr\u003e\u003ci\u003eKenneth L. Hastings\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Weight of Evidence Review: A New Strategy In Immunotoxicology 11\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Clinical Pathology as Crucial Insight into Immunotoxicity Testing 13\u003cbr\u003e\u003ci\u003eEllen Evans\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.2 Histomorphology of the Immune System: A Basic Step in Assessing Immunotoxicity 27\u003cbr\u003e\u003ci\u003ePatrick Haley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.3 Need for Specialized Immunotoxicity Tests 45\u003cbr\u003e\u003ci\u003eKazuichi Nakamura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.4 Specific Drug-Induced Immunotoxicity: Immune-Mediated Hemolytic Anemia 55\u003cbr\u003e\u003ci\u003eRaj Krishnaraj\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Nonclinical Core Immunotoxicity Testing In Drug Development 65\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1.1 T Cell-Dependent Antibody Response Tests 67\u003cbr\u003e\u003ci\u003eJoseph R. Piccotti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1.2 Natural Killer Cell Assay and Other Innate Immunity Tests 77\u003cbr\u003e\u003ci\u003eLisa Plitnick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1.3 Cellular Immune Response in Delayed-Type Hypersensitivity Test 87\u003cbr\u003e\u003ci\u003eKaren Price\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.2 Evaluation of Drug Effects on Immune Cell Phenotypes 103\u003cbr\u003e\u003ci\u003eLaurie Iciek\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Extended Immunotoxicology Assessment: \u003ci\u003eEx Vivo \u003c\/i\u003eModels 125\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Functional Cellular Responses and Cytokine Profiles 127\u003cbr\u003e\u003ci\u003eElizabeth R. Gore\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.2 Application of Flow Cytometry in Drug Development 141\u003cbr\u003e\u003ci\u003ePadma Narayanan, Renold J. Capocasale, Nianyu Li, and Peter J. Bugelski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Extended Immunotoxicology Assessment: \u003ci\u003eIn Vivo \u003c\/i\u003eModels 161\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Animal Models of Host Resistance 163\u003cbr\u003e\u003ci\u003eGary R. Burleson and Florence G. Burleson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.2 Approaches to Evaluation of Autoimmunity 179\u003cbr\u003e\u003ci\u003eDanuta J. Herzyk\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VI Immunotoxicity Testing In Biopharmaceutical Development 189\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Differentiation between Desired Immunomodulation and Potential Immunotoxicity 191\u003cbr\u003e\u003ci\u003eJeanine L. Bussiere and Barbara Mounho\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.2 Relevant Immune Tests across Different Species and Surrogate Models 199\u003cbr\u003e\u003ci\u003eJeanine L. Bussiere\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.3 Antidrug Antibody Responses in Nonclinical Studies and Their Implications 209\u003cbr\u003e\u003ci\u003eBarbara Mounho\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VII Development of Vaccines 217\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Pharmacological Immunogenicity and Adverse Responses to Vaccines 219\u003cbr\u003e\u003ci\u003eMary Kate Hart, Mark Bolanowski, and Robert V. House\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.2 Immunotoxicological Concerns for Vaccines and Adjuvants 229\u003cbr\u003e\u003ci\u003eCatherine Kaplanski, Jose Lebron, Jayanthi Wolf, and Brian Ledwith\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VIII Testing For Drug Hypersensitivity 239\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Systemic Hypersensitivity 241\u003cbr\u003e\u003ci\u003eRaymond Pieters\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.2 Nonclinical Models to Assess Respiratory Hypersensitivity Potential 257\u003cbr\u003e\u003ci\u003eCurtis C. Maier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IX Testing For Developmental Immunotoxicity 271\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Developmental Immunotoxicity in Rodents 273\u003cbr\u003e\u003ci\u003eRodney R. Dietert and Leigh Ann Burns-Naas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.2 Developmental Immunotoxicity in Nonhuman Primates 299\u003cbr\u003e\u003ci\u003ePauline L. Martin and Eberhard Buse\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart X New Methods In Assessing Immunomodulation, Immunotoxicity, and Immunogenicity 319\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Alternative Animal Models for Immunomodulation and Immunotoxicity 321\u003cbr\u003e\u003ci\u003ePeter J. Bugelski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.2 Animal Models for Preclinical Comparative Immunogenicity Testing 345\u003cbr\u003e\u003ci\u003eDaniel Wierda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.3 T Cell Epitopes and Minimization of Immunogenicity 361\u003cbr\u003e\u003ci\u003eHarald Kropshoffer and Thomas Singer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart XI Bridging Immunotoxicology To Clinical Drug Development 373\u003cbr\u003e\u003cbr\u003e\u003c\/b\u003e11 Bridging Immunotoxicology to Clinical Drug Development 375\u003cbr\u003e\u003ci\u003eIan Gourley and Jacques Descotes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 385\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Interscience","offers":[{"title":"Brand New","offer_id":52257074905368,"sku":"9780470122389","price":128.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470122389.jpg?v=1781276301","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/immunotoxicology-strategies-for-pharmaceutical-safety-assessment-hardback-9780470122389","provider":"Freshly Printed Books","version":"1.0","type":"link"}