{"product_id":"hepatotoxicity-from-genomics-to-in-vitro-and-in-vivo-models-hardback-9780470057162","title":"Hepatotoxicity; From Genomics to In Vitro and In Vivo Models (Hardback) 9780470057162","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eHepatotoxicity\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eFrom Genomics to In Vitro and In Vivo Models\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eSaura C. Sahu (Edited by), SC Sahu (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470057162, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 14 December 2007\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e704 pages\u003cbr\u003e25 x 17.5 x 4.4 cm, 1.389 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"This provides valuable insight into the current and future directions of research in this field and wil be a valuable resource of up-to-date information for toxicologists, risk assessors, and regulators in academia, industry and government.\" (\u003ci\u003eDoody's\u003c\/i\u003e, August 2008)\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThis book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals.  \u003cp\u003eContributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action.\u003c\/p\u003e \u003cp\u003eThis valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003eAcknowledgements xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 1 Models for Hepatotoxicity Testing\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Current in vitro Models to Study Drug-Induced Liver Injury 3\u003cbr\u003e\u003ci\u003eJulio C. Davila, Jinghai J. Xu, Keith A. Hoffmaster, Peter J. O’Brien and Stephen C. Storm\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Utilization of an in vitro Hepatotoxicity Test in the Early Stage of Drug Discovery 57\u003cbr\u003e\u003ci\u003eIkuo Horii, Hiroshi Yamada, Rie Kikkawa, Toshinori Yamamoto, Tamio Fukushima and Kaori Tomizawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Use of Hepatocytes for Characterizing a Candidate Drug’s Metabolism and Drug Interaction Potential 69\u003cbr\u003e\u003ci\u003eSrikanth C. Nallani, John M. Strong and Shiew Mei Huang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Human-Based in vitro Experimental Systems for the Evaluation of Human Drug Safety 89\u003cbr\u003e\u003ci\u003eAlbert P. li\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Hepatocytes as a Model for Screening Food-Related Hepatotoxins and Studying Mechanisms of their Toxicity 105\u003cbr\u003e\u003ci\u003eSaura C. Sahu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Some Experimental Models of Liver Damage 119\u003cbr\u003e\u003ci\u003ePablo Muriel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 2 Hepatocyte Cultures\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7 Application of Short- and Long-Term Hepatocyte Cultures to Predict Toxicities 141\u003cbr\u003e\u003ci\u003eGregor Tuschl, Jens Hrach, Philip G. Hewitt and Stefan O. Mueller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 3 Biomarkers of Hepatotoxicity\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 Biomarkers of Mycotoxin Exposure in Liver Toxicity 177\u003cbr\u003e\u003ci\u003eAngela J. Harris\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 4 Mechanisms of Hepatotoxicity\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9 Mechanisms of Toxic Liver Injury 191\u003cbr\u003e\u003ci\u003eNora Anderson and Jürgen Borlak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 A Role of Cytochrome P450 in Quinone-Induced Hepatotoxicity 287\u003cbr\u003e\u003ci\u003eYasuhiro Ishihara and Norio Shimamoto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 A Mechanistic View of Troglitazone Hepatotoxicity 299\u003cbr\u003e\u003ci\u003eRawiwan Maniratanachote and Tsuyoshi Yokoi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Role of the Kupffer Cell in Hepatotoxicity and Hepatocarcinogenesis 313\u003cbr\u003e\u003ci\u003eJames E. Klaunig, Stacy M. Corthals, Lisa M. Kamendulis and Binu K. Philip\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Sinusoidal Cells in Liver Injury and Repair 341\u003cbr\u003e\u003ci\u003eCarol R. Gardner and Debra L. Laskin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Cytokines in Liver Diseases 371\u003cbr\u003e\u003ci\u003ePablo Muriel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Bile Acids as Modulators of Apoptosis 391\u003cbr\u003e\u003ci\u003eRui E. Castro, Susana Solá, Clifford J. Steer and Cecília M.P. Rodrigues\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Drug-Induced Intrahepatic Cholestasis by Interaction with the Hepatic Bile Salt Export Pump (BSEP) 421\u003cbr\u003e\u003ci\u003eChristoph Funk, Johannes Noé, Renée Portmann, Ruben Alvarez-Sánchez, Florian Klammers, Christiane Lamy, Axel Paehler and Michael Pantze\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 5 Genomics of Hepatotoxicity\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17 Application of Toxicogenomics in Predicting Hepatotoxicity – Potentials and Challenges 449\u003cbr\u003e\u003ci\u003eWen Lin, Guoxiang Shen, Tin Oo Khor and Ah-Ng Tony Kong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Genomic Profiling of Liver Injury 465\u003cbr\u003e\u003ci\u003eKevin Gerrish and David E. Malarkey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Use of DNA Arrays in Understanding Hepatic Test Systems 489\u003cbr\u003e\u003ci\u003eAngela J. Harris and Daniel A. Casciano\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Prediction of Hepatotoxicity Based on the Toxicogenomics Database 507\u003cbr\u003e\u003ci\u003eTetsuro Urushidani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Relationship between N-acetyltransferase-2 Gene Polymorphism and Isoniazid-Induced Hepatotoxicity 531\u003cbr\u003e\u003ci\u003eYasuo Shimizu, Kunio Dobashi and Masatomo Mori\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 6 Gender Differences in Hepatotoxicity\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e22 Human and Animal-Based Differences in Hepatic Xenobiotic Metabolism and Toxicity 539\u003cbr\u003e\u003ci\u003ePeter J. O’Brien, Katie Chan and Raymond J. Poon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 7 Hepatotoxicity and Hepatocarcinogenicity\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e23 Hepatotoxicity in Oncology Drug Development 565\u003cbr\u003e\u003ci\u003eWei Chen, Kenneth Hastings and John K. Leighton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 The Potent Rat Hepatocarcinogen Methapyrilene: An Hypothesis Regarding its Hepatotoxicology 577\u003cbr\u003e\u003ci\u003eDaniel A. Casciano\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 8 Hepatotoxicity and Botanical Supplements\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e25 Botanical Supplements and Hepatotoxicity 591\u003cbr\u003e\u003ci\u003eShabana Khan, Ikhlas Khan and Larry Walker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 9 Risk Analysis of Hepatotoxins\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e26 Physiologically Based Pharmokinetic Modeling and Risk Assessment of Hepatotoxicants 609\u003cbr\u003e\u003ci\u003eKannan Krishnan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 635\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52256843792664,"sku":"9780470057162","price":164.39,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470057162.jpg?v=1781275208","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/hepatotoxicity-from-genomics-to-in-vitro-and-in-vivo-models-hardback-9780470057162","provider":"Freshly Printed Books","version":"1.0","type":"link"}