{"product_id":"hepatobiliary-cancers-translational-advances-and-molecular-medicine-hardback-9780323983921","title":"Hepatobiliary Cancers: Translational Advances and Molecular Medicine (Hardback) 9780323983921","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eHepatobiliary Cancers: Translational Advances and Molecular Medicine\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eA comprehensive, timely, and authoritative volume highlighting recent basic, translational, and clinical research advances and challenges aimed at fostering new mechanistic insights into hepatobiliary cancer (hepatocellular carcinoma and cholangiocarcinoma) pathogenesis and developing predictive and therapeutic strategies\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eAlphonse E. Sirica (Volume editor), Paul B. Fisher (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780323983921, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 18 August 2022\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e466 pages\u003cbr\u003e22.9 x 15.2 x 2.9 cm, 0.45 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eHepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where  treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC)  and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing  a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in  promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis;  advances in molecular genomics for personalizing tumor classification and targeted therapies;  innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. Liver Cancer Risk-Predictive Molecular Biomarkers Specific to Clinico-epidemiological Contexts\u003cbr\u003e\u003ci\u003eYujin Hoshida, Naoto Kubota, Naoto Fujiwara\u003cbr\u003e\u003c\/i\u003e2. Inflammatory Pathways and Hepatobiliary Cancer Risk Mechanisms and Prevention\u003cbr\u003e\u003ci\u003eMario Strazzabosco and Massimiliamo Cadamuro\u003cbr\u003e\u003c\/i\u003e3. Causes and Functional Intricacies of Inter- and Intratumor Heterogeneity in Primary Liver Cancers\u003cbr\u003e\u003ci\u003eXin Wei Wang and Subreen Khatib\u003cbr\u003e\u003c\/i\u003e4. Implication of Genetic Heterogeneity in Hepatocellular Cancer \u003cbr\u003e\u003ci\u003eRenumathy Dhanasekaran\u003cbr\u003e\u003c\/i\u003e5. Understanding the Genetic Basis for Cholangiocarcinoma\u003cbr\u003e\u003ci\u003eLewis R. Roberts and Mikayla A. Schmidt\u003cbr\u003e\u003c\/i\u003e6. Novel Insights into Molecular and Immune Subtypes of Intrahepatic Cholangiocarcinoma\u003cbr\u003e\u003ci\u003eDaniela Sia and Emily Bramel\u003cbr\u003e\u003c\/i\u003e7. Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma Progression and Therapeutic Resistance\u003cbr\u003e\u003ci\u003eSilvia Affo, Aashreya Ravichandra, Sonakshi Bhattacharjee \u003cbr\u003e\u003c\/i\u003e8. Mechanisms and Clinical Significance of TGF-ß in Hepatobiliary Cancer Progression \u003cbr\u003e\u003ci\u003eLopa Mishra and Zobia Zaidi\u003cbr\u003e\u003c\/i\u003e9. Matricellular proteins in intrahepatic cholangiocarcinoma\u003cbr\u003e\u003ci\u003eAlphonse Eugene Sirica\u003cbr\u003e\u003c\/i\u003e10. Yap Activation and Hippo Pathway Signaling in the Pathogenesis and Prognosis of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma\u003cbr\u003e\u003ci\u003eSatdarshan (Paul) Singh Monga, Sungjin Ko, Yuhua Xue, George K. Michalopoulos, \u003cbr\u003e\u003c\/i\u003e11. Patient-derived Functional Organoids as a Personalized Approach for Drug Screening Against Hepatobiliary Cancers\u003cbr\u003e\u003ci\u003eFlorin M. Selaru and Ling Li \u003cbr\u003e\u003c\/i\u003e12. Molecular Therapeutic Targets for Cholangiocarcinoma: Present Challenges and Future Possibilities\u003cbr\u003e\u003ci\u003eJesper B. Andersen, Colm J. O’Rourke, Dan Høgdall\u003cbr\u003e\u003c\/i\u003e13. Immunotherapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Current and Developing Strategies\u003cbr\u003e\u003ci\u003eBruno Sangro and Josepmaria Argemi\u003cbr\u003e\u003c\/i\u003e14. Immunotherapy for Hepatobiliary Cancers: Emerging Targets and Translational Advances\u003cbr\u003e\u003ci\u003eMitchell Ho, Dan Li, Shaoli Lin, Jessica Hong \u003c\/i\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Virology [\u003ca title=\"See our other books on Virology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Virology%20%5Bnon-medical%5D%20%5BPSGL%5D%22\"\u003enon-medical PSGL\u003c\/a\u003e], Cellular biology [\u003ca title=\"See our other books on Cellular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cellular%20biology%20%5Bcytology%5D%20%5BPSF%5D%22\"\u003ecytology PSF\u003c\/a\u003e], Genetics [\u003ca title=\"See our other books on Genetics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Genetics%20%5Bnon-medical%5D%20%5BPSAK%5D%22\"\u003enon-medical PSAK\u003c\/a\u003e], Immunology [\u003ca title=\"See our other books on Immunology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Immunology%20%5BMJCM%5D%22\"\u003eMJCM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46651235893528,"sku":"9780323983921","price":106.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780323983921_09553b95-4732-4517-b9e7-aa05887a8ed3.jpg?v=1695003924","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/hepatobiliary-cancers-translational-advances-and-molecular-medicine-hardback-9780323983921","provider":"Freshly Printed Books","version":"1.0","type":"link"}