{"product_id":"glycogen-synthase-kinase-3-gsk-3-and-its-inhibitors-drug-discovery-and-development-hardback-9780471770015","title":"Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors; Drug Discovery and Development (Hardback) 9780471770015","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eGlycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eDrug Discovery and Development\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eAna Martinez (Edited by), A Martinez (Author), Ana Castro (Edited by), Miguel Medina (Edited by), Binghe Wang (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780471770015, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 3 November 2006\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e384 pages\u003cbr\u003e24.3 x 16.1 x 2.4 cm, 0.658 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eMany researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It’s a great reference for researchers in drug design and development.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eForeword: The Origins of GSK-3.  \u003cp\u003e\u003c\/p\u003e Preface.  \u003cp\u003e\u003c\/p\u003e Acknowledgments.  \u003cp\u003e\u003c\/p\u003e Contributors.  \u003cp\u003e\u003c\/p\u003e Abbreviations.   \u003cp\u003e\u003c\/p\u003e \u003cb\u003ePART I: CELLULAR FUNCTIONS OF GSK-3.\u003c\/b\u003e  \u003cp\u003e\u003c\/p\u003e 1. Glycogen Synthase Kinase-3 - an Introductory Synopsis  .  \u003cp\u003e\u003c\/p\u003e 2. Glycogen-Synthase-Kinase-β (GSK-3β) a Key Signaling Enzyme: A Developmental Neurobiological Perspective.  \u003cp\u003e\u003c\/p\u003e 3. Role of GSK3\/Shaggy in neuronal cell biology.  \u003cp\u003e\u003c\/p\u003e 4. The \u003cst1:place w:st=\"on\"\u003e\u003cst1:city w:st=\"on\"\u003eCrystal\u003c\/st1:city\u003e\u003c\/st1:place\u003e Structures of Glycogen Synthase Kinase 3.  \u003cp\u003e\u003c\/p\u003e 5. Kinase-Kinase and Site-Site Interactions in the Phosphorylation of Tau by GSK-3.  \u003cp\u003e\u003c\/p\u003e \u003cb\u003ePART II: GSK3 AS A THERAPEUTIC TARGET IN HUMAN PATHOLOGY.\u003c\/b\u003e  \u003cp\u003e\u003c\/p\u003e 6. GSK-3, a Key Player in Alzheimer’s Disease.  \u003cp\u003e\u003c\/p\u003e 7. Glycogen Synthase Kinase-3: A Target for Novel Mood Disorder Treatments.  \u003cp\u003e\u003c\/p\u003e 8. GSK3 and Stem Cells.  \u003cp\u003e\u003c\/p\u003e 9. Glycogen Synthase Kinase-3: role in Neurodegeneration and Neuroprotection.  \u003cp\u003e\u003c\/p\u003e 10. Protein Kinase Inhibitors. Assay Development.  \u003cp\u003e\u003c\/p\u003e 11. Animal Models with Modified Expression of GSK-3 for the Study of Its Physiology and of Its Implications in Human Pathologies.  \u003cp\u003e\u003c\/p\u003e \u003cb\u003ePART III: GSK-3 INHIBITORS: DEVELOPMENT AND THERAPEUTIC POTENTIAL.\u003c\/b\u003e  \u003cp\u003e\u003c\/p\u003e 12. Lithium, the Seminal GSK3 Inhibitor.  \u003cp\u003e\u003c\/p\u003e 13. Inhibition of GSK3 as Therapeutic Strategy in Disease: Efficacy of AR-A014418.  \u003cp\u003e\u003c\/p\u003e 14. TDZD’s: Selective And ATP Non Competitive Glycogen Synthase Kinase-3 Inhibitors.  \u003cp\u003e\u003c\/p\u003e 15. 3-Amino Pyrazoles as Potent and Selective Glycogen Synthase (GSK-3) Inhibitors.  \u003cp\u003e\u003c\/p\u003e 16. Marine compounds as a new source for Glycogen Synthase Kinase-3 Inhibitors.  \u003cp\u003e\u003c\/p\u003e Index.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Interscience","offers":[{"title":"Brand New","offer_id":52298052960536,"sku":"9780471770015","price":124.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780471770015.jpg?v=1781733130","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/glycogen-synthase-kinase-3-gsk-3-and-its-inhibitors-drug-discovery-and-development-hardback-9780471770015","provider":"Freshly Printed Books","version":"1.0","type":"link"}