{"product_id":"gigantism-and-acromegaly-paperback-9780128145371","title":"Gigantism and Acromegaly (Paperback) 9780128145371","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eGigantism and Acromegaly\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eProvides a single up-to-date reference on the molecular genetics of gigantism and acromegaly due to excess growth hormone\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eConstantine A. Stratakis (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128145371, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 9 June 2021\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e310 pages\u003cbr\u003e23.4 x 19 x 2 cm, 0.66 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eGigantism and Acromegaly \u003c\/i\u003ebrings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management.\u003c\/p\u003e  \u003cp\u003eAcromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e1. History of the identification of gigantism and acromegaly \u003ci\u003eLiliya Rostomyan, Albert Beckers and Patrick Petrossians \u003c\/i\u003e2. Pathology of pituitary growth hormone excess \u003ci\u003eSylvia L. Asa and Shereen Ezzat \u003c\/i\u003e3. Gigantism: clinical diagnosis and description, \u003ci\u003eIulia Potorac Liliya Rostomyan, Adrian F. Daly, Patrick Petrossians and Albert Beckers \u003c\/i\u003e4. Acromegaly: clinical description and diagnosis \u003ci\u003eKevin C.J. Yuen and Albert Becker \u003c\/i\u003e5. GPR101, an orphan G-protein coupled receptor, with roles in growth, puberty, and possibly appetite regulation \u003ci\u003eFady Hannah-Shmouni and Constantine A. Stratakis \u003c\/i\u003e6. The role of the aryl hydrocarbon receptor interacting protein in pituitary tumorigenesis\u003ci\u003e \u003c\/i\u003e\u003ci\u003eLaura C. Herna´ndez-Rami´rez \u003c\/i\u003e7. The 3PAs syndrome and succinate dehydrogenase deficiency in pituitary tumors \u003ci\u003eParaskevi Xekouki, Vasiliki Daraki, Grigoria Betsi, Maria Chrysoulaki, Maria Sfakiotaki, Maria Mytilinaiou and Constantine A. Stratakis \u003c\/i\u003e8. CDKN1B (p27) defects leading to pituitary tumors \u003ci\u003eSebastian Gulde and Natalia S. Pellegata \u003c\/i\u003e9. Multiple endocrine neoplasia syndromes and somatotroph adenomas \u003ci\u003eCarolina R.C. Pieterman and Steven G. Waguespack \u003c\/i\u003e10. GNAS, McCune\u003calbright\u003eErika Peverelli, Donatella Treppiedi, Federica Mangili Rosa Catalano and Giovanna Mantovani 11. Surgical management of growth hormone-secreting adenomas \u003ci\u003eElizabeth Hogan and Prashant Chittiboina \u003c\/i\u003e12. Medical management of pituitary gigantism and acromegaly \u003ci\u003eAdrian F. Daly and Albert Beckers  \u003c\/i\u003e13. GHRH-producing tumors and other neuroendocrine neoplasms associated with acromegaly and\/or gigantism \u003ci\u003eSara Pakbaz, Anjelica Hodgson and Ozgur Mete  \u003c\/i\u003e14. Increased growth hormone secretion from lesions outside the anterior pituitary \u003ci\u003eChristina Tatsi and Constantine A. Stratakis\u003c\/i\u003e\u003c\/albright\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Genetics [\u003ca title=\"See our other books on Genetics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Genetics%20%5Bnon-medical%5D%20%5BPSAK%5D%22\"\u003enon-medical PSAK\u003c\/a\u003e], Endocrinology [\u003ca title=\"See our other books on Endocrinology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Endocrinology%20%5BMJG%5D%22\"\u003eMJG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649938968856,"sku":"9780128145371","price":86.27,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128145371.jpg?v=1694104642","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/gigantism-and-acromegaly-paperback-9780128145371","provider":"Freshly Printed Books","version":"1.0","type":"link"}