{"product_id":"genetics-of-bone-biology-and-skeletal-disease-hardback-9780128041826","title":"Genetics of Bone Biology and Skeletal Disease (Hardback) 9780128041826","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eGenetics of Bone Biology and Skeletal Disease\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003eThis comprehensive, translational reference for students of bone biology and genetics covers the genetic basis of bone disorders in humans\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eRajesh V. Thakker (Edited by), Michael P. Whyte (Edited by), John Eisman (Edited by), Takashi Igarashi (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128041826\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 31 October 2017\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e878 pages\u003cbr\u003e27.6 x 21.5 x 4.3 cm, 2.63 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eGenetics of Bone Biology and Skeletal Disease, Second Edition,\u003c\/i\u003e is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. \u003c\/p\u003e  \u003cp\u003eThe first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. \u003c\/p\u003e  \u003cp\u003eThe third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePart 1: General Background to Bone Biology Part 2: General Background to Genetics Part 3: Disorders of Bone and Joint Part 4: Parathyroid and Related Disorders Part 5: Vitamin and Renal Disorders\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Genetics [\u003ca title=\"See our other books on Genetics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Genetics%20%5Bnon-medical%5D%20%5BPSAK%5D%22\"\u003enon-medical PSAK\u003c\/a\u003e], Orthopaedics \u0026amp; fractures [\u003ca title=\"See our other books on Orthopaedics \u0026amp; fractures\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Orthopaedics%20\u0026amp;%20fractures%20%5BMNS%5D%22\"\u003eMNS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649625903384,"sku":"9780128041826","price":137.39,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128041826_11548080-ecff-4631-a11a-449ee7821987.jpg?v=1694353160","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/genetics-of-bone-biology-and-skeletal-disease-hardback-9780128041826","provider":"Freshly Printed Books","version":"1.0","type":"link"}