{"product_id":"fundamentals-of-early-clinical-drug-development-from-synthesis-design-to-formulation-hardback-9780471692782","title":"Fundamentals of Early Clinical Drug Development; From Synthesis Design to Formulation (Hardback) 9780471692782","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eFundamentals of Early Clinical Drug Development\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eFrom Synthesis Design to Formulation\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eAhmed F. Abdel-Magid (Author), Stéphane Caron (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780471692782, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 3 October 2006\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e354 pages\u003cbr\u003e24.1 x 16 x 2.2 cm, 0.599 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"This book will give a lot of pleasure and information to the medicinal chemist, the synthetic organic chemist, and anyone involved in taking a drug candidate to the stage of pharmaceutical formulation.\" (\u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e, December 28, 2006)  \u003cp\u003e‘…this is an excellent book…It is highly recommended to all scientists involved in developing new processes for APIs.’ (\u003ci\u003eOrganic Process Research and Development Journal,\u003c\/i\u003e July 2007)\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eAn informative look at the intricacies of today's drug development process\u003cbr\u003e \u003cbr\u003e \u003cbr\u003e \u003cbr\u003e Once a discovery organization has identified a potential new drug candidate, it is the daunting task of synthetic organic chemists to identify the chemical process suitable for preparation of this compound in a highly regulated environment. Only through a multi-layered chemical process that takes into account such factors as safety, environmental considerations, freedom to operate and cost-effectiveness can researchers begin to refine the drug in terms of quality and yield.\u003cbr\u003e \u003cbr\u003e This book covers both recent advances in the design and synthesis of new drugs, as well as the myriad other issues facing a new drug candidate as it moves through the development process. Utilizing recent case studies, the authors provide valuable insights into the complexities of the process, from designing new synthetic methodologies and applying new automated techniques for finding optimal reaction conditions to selecting the final drug form and formulation.\u003cbr\u003e \u003cbr\u003e Both novice and active researchers will appreciate the inclusion of chapters on such diverse topics as:\u003cbr\u003e * Cross-coupling methods\u003cbr\u003e * Asymmetric synthesis\u003cbr\u003e * Automation\u003cbr\u003e * Chemical Engineering\u003cbr\u003e * Application of radioisotopes\u003cbr\u003e * Final form selection\u003cbr\u003e * Formulations\u003cbr\u003e * Intellectual property\u003cbr\u003e \u003cbr\u003e \u003cbr\u003e A wealth of real-world examples and contributions from leading process scientists, engineers, and related professionals make this book a valuable addition to the scientific literature.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eContributors.  \u003cp\u003ePreface.\u003c\/p\u003e \u003cp\u003e1. Reflections on Process Research II (\u003ci\u003eEdward J. J. Grabowski\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2. Development and Scale-Up of a Heterocyclic Cross-Coupling for the Synthesis of 5-[2-(3-Methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridine-7-yl] amino-2-methyl-1H-indole (\u003ci\u003eJohn A. Ragan\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3. Large-Scale Enantioselective Preparation of 2E,7E, 5S,6R,5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoic Acid, a Key Fragment for the Formal Total Synthesis of the Anti-tumor Agent Cryptophycin 52 (\u003ci\u003eJames Aikins, Tony Y. Zhang, Milton Zmijewski, and Barbara Briggs\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4. Efforts Toward a Commercially Viable Route and Process to the Synthesis of HIV PI GW640385X (\u003ci\u003eJohn C. Roberts, Roman Davis, Brian D. Doan, Thomas C. Lovelace, Daniel E. Patterson, Frank Roschangar, Barry Sickles, Jennifer F. Toczko, and Ju Yang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5. Development of an Asymmetric Synthesis of ABT-100 (\u003ci\u003eAlbert W. Kruger, Michael J. Rozema, Bridget D. Rohde, Bhadra Shelat, Lakshmi Bhagavatula, James J. Tien, Weijiang Zhang, and Rodger F. Henry\u003c\/i\u003e)\u003c\/p\u003e \u003cp\u003e6. Asymmetric Hydrogenation: A New Route to Pregabalin (\u003ci\u003eRex Jennings, William S. Kissel, Tung V. Le, Edward Lenoir, Thomas Mulhern, and Robert Wade\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7. Responsibilities of the Process Chemist: Beyond Synthetic Organic Chemistry (\u003ci\u003eStéphane Caron\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8. Outsourcing—The Challenge of Science, Speed, and Quality (\u003ci\u003eSimone Andler-Burzlaff, Jason Bertola, and Roger E. Marti\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9. Automation and the Changing Face of Process Research in the Pharmaceutical Industry (\u003ci\u003eEdward J. Delaney, Merrill L. Davies, Brent D. Karcher, Victor W. Rosso, A. Erik Rubin, and John J. Venit\u003c\/i\u003e)\u003c\/p\u003e \u003cp\u003e10. Large-Scale Synthesis: An Engineering Perspective (\u003ci\u003eJoseph H. Childers, Jr.\u003c\/i\u003e)\u003c\/p\u003e \u003cp\u003e11. Synthesis and Application of Radioisotopes in Pharmaceutical Research and Development (\u003ci\u003eLarry E. Weaner and David C. Hoerr\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e12. Selection of the Drug Form in Exploratory Development (\u003ci\u003eGeorge J. Quallich\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13. Strategies to Achieve Particle Size of Active Pharmaceutical Ingredients (\u003ci\u003eDavid J. am Ende and Peter R. Rose\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e14. Challenges in Early Formulation: Turning Drug Substance into Drug Product (\u003ci\u003eMark H. Kleinman and Beeah Lee\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15. Intellectual Property and Early Development (\u003ci\u003eMaria I. Shchuka\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Interscience","offers":[{"title":"Brand New","offer_id":52298035626264,"sku":"9780471692782","price":99.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780471692782.jpg?v=1781731895","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/fundamentals-of-early-clinical-drug-development-from-synthesis-design-to-formulation-hardback-9780471692782","provider":"Freshly Printed Books","version":"1.0","type":"link"}