{"product_id":"fragment-based-drug-discovery-a-practical-approach-hardback-9780470058138","title":"Fragment-Based Drug Discovery; A Practical Approach (Hardback) 9780470058138","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eFragment-Based Drug Discovery\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eA Practical Approach\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eEdward R. Zartler (Edited by), E Zartler (Author), Michael Shapiro (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470058138, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 17 October 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e296 pages\u003cbr\u003e25.1 x 17.6 x 2.2 cm, 0.709 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"This is a useful book for readers already familiar with the basic aspects of drug design and discovery.\" (\u003ci\u003eChemMedChem\u003c\/i\u003e, October 2009)  \u003cp\u003e \"This book provides an excellent resource for those in pharmaceutical research who are interested in fragment-based drug discovery. Most of the topics are covered in enough detail that this book could be used as a guide for those initiating a program in fragment-based drug discovery.\" (\u003ci\u003eJournal of the American Chemical Society\u003c\/i\u003e, April 29, 2009)\u003c\/p\u003e  \u003cp\u003e \"As the authors eloquently state in Chapter 2, 'Where there is a validated target and a will, there is a (drug discovery) way.'\" (\u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e, 2009)\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eFragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery.  \u003cp\u003e\u003ci\u003eFragment-Based Drug Discovery: A Practical Approach\u003c\/i\u003e is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include:\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003ean introduction to  fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort.\u003c\/li\u003e \u003cli\u003esetting up an FBDD project\u003c\/li\u003e \u003cli\u003elibrary building and production\u003c\/li\u003e \u003cli\u003eNMR in fragment screening and follow up\u003c\/li\u003e \u003c\/ul\u003e \u003cul type=\"disc\"\u003e \u003cli\u003eapplication of protein-ligand NOE matching to the rapid evaluation of fragment binding poses\u003c\/li\u003e \u003cli\u003etarget immobilized NMR screening: validation and extension to membrane proteins\u003c\/li\u003e \u003cli\u003e\n\u003ci\u003ein situ\u003c\/i\u003e fragment-based medicinal chemistry: screening by mass spectrometry\u003c\/li\u003e \u003cli\u003ecomputational approaches to fragment and substructure discovery and evaluation\u003c\/li\u003e \u003cli\u003evirtual fragment scanning:  current trends, applications and web based tools\u003c\/li\u003e \u003cli\u003efragment-based lead discovery using covalent capture methods\u003c\/li\u003e \u003cli\u003ecase study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generation\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWith contributions from industry experts who have successfully set up an industrial fragment-based research program, \u003ci\u003eFragment-Based Drug Discovery: A Practical Approach\u003c\/i\u003e offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. Introduction to Fragment based Drug Discovery (Tim Mitchell and Mike Cherry).  \u003cp\u003e2. Building the Perfect Beast: Designing a Fragment Process to Fit Your Needs (Edward Zartler and Michael Shapiro).\u003c\/p\u003e \u003cp\u003e3. Assembling a Fragment Library (Mark Brewer, Osamu Ichihara, Christian Kirchhoff, Markus Schade, and Mark Whittaker).\u003c\/p\u003e \u003cp\u003e4. The Practical Aspects of Using NMR in Fragment Based Screening (Johan Schultz).\u003c\/p\u003e \u003cp\u003e5. Application of Protein-Ligand NOE Matching to the Rapid Evaluation of Fragment Binding Poses (William J. Metzler, Brian L. Claus, Patricia McDonnell, Stephen R. Johnson, Valentina Goldfarb, Malcolm E. Davis, Luciano Mueller, and Keith L. Constantine).\u003c\/p\u003e \u003cp\u003e6. Target Immobilized NMR Screening: Validation and Extension to Membrane Proteins (Virginie Früh, Robert J. Heetebrij and Gregg Siegal).\u003c\/p\u003e \u003cp\u003e7. In situ fragment-based medicinal chemistry: screening by mass spectrometry (Sally-Ann Poulsen and Gary H. Kruppa).\u003c\/p\u003e \u003cp\u003e8. Computational approaches to fragment and substructure discovery and evaluation (Eelke van der Horst and Adriaan P. IJzerman).\u003c\/p\u003e \u003cp\u003e9. In Silico Design Chapter (Bradley Feuston, M. Katharine Holloway, Georgia McGaughey and J. Chris Culberson).\u003c\/p\u003e \u003cp\u003e10. Fragment-based lead discovery using covalent capture methods (Stig K. Hansen and Daniel A. Erlanson).\u003c\/p\u003e \u003cp\u003e11. Identification of high affinity beta-secretase inhibitors using fragment-based lead generation.\u003c\/p\u003e \u003cp\u003eJeffrey S. Albert and Philip D. Edwards.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52256844284184,"sku":"9780470058138","price":125.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470058138.jpg?v=1781275212","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/fragment-based-drug-discovery-a-practical-approach-hardback-9780470058138","provider":"Freshly Printed Books","version":"1.0","type":"link"}